Clinical trials: Capsaicin
Healthy
Effect Of PF-06305591 On Capsaicin And Capsaicin/Heat-Induced Neurogenic Flare
The purpose of this study is to examine the effect of PF-06305591 on capsaicin and capsaicin/heat-induced neurogenic flare.
- Trial name
- NCT01797796
- Testing
- PF-06305591, Capsaicin challenge
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tolerance, Capsaicin
Intranasal Capsaicinoid Spray
Rhinitis is inflammation of the inside of the nose. Symptoms of rhinitis include itchiness, sneezing, and a "runny" nose (rhinorrhea).
- Conditions
- Tolerance, Capsaicin, Rhinitis
- Trial name
- NCT03952845
- Testing
- Capsaicinoid
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Pain, Burning, Capsaicin
Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception
In This experiment, the investigators would like to test following hypotheses: the pain stimulation applied at the same time of a pruriceptive stimulus will decrease the itch perception.
- Trial name
- NCT06185582
- Testing
- Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Bioavailability
Oral Bioavailability of Two Melatonin Supplements
Results from several clinical studies show that orally administered melatonin has low bioavailability and a very short half-life.
- Trial name
- MELFENIL (NCT05835258)
- Testing
- Melatonin with phenyl capsaicin, Melatonin without phenyl capsaicin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Hyperalgesia, Allodynia
Fenobam on Heat/Capsaicin Induced Hyperalgesia in Healthy Volunteers
Our goal is to demonstrate that healthy volunteers treated with fenobam will develop a significantly reduced area of cutaneous hyperalgesia compared to volunteers treated with placebo, after exposure to the heat/capsaicin model…
- Trial name
- NCT01981395
- Testing
- Fenobam
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Laura Cavallone
Cough
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients
Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation.
- Trial name
- NCT03722849
- Testing
- Adenosine Triphosphate, Capsaicin, Functional Brain Imaging
- Where
- Australia
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stuart Mazzone
Pain
A Study to Investigate the Tolerability and Effects on Epidermal Nerve Fiber Density of Multiple Low-Concentrations of NGX-1998 in Healthy Volunteers
The purpose of this single-blinded study in healthy volunteers is to select a Low-Concentration Capsaicin Topical Liquid (LC-CTL) to serve as a control formulation in the further clinical development of Capsaicin Topical Liquid…
- Trial name
- NCT00912262
- Testing
- Capsaicin Topical Liquid
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NeurogesX
Cough
The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects
This is a First Time in Human (FTIH) study for the sodium channel inhibitor, GSK2339345. The study is split into two parts. Part A will assess the safety and tolerability of the new drug.
- Trial name
- FTIH (NCT01494636)
- Testing
- GSK2339345 (solution), GSK2339345 (nebulised), Lidocaine
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dermatitis, Atopic
Investigation of Topical SB705498 on Healthy Volunteers
A two part, randomized, double-blind, placebo controlled study to investigate the effects of topical doses of SB705498 in healthy volunteers.
- Trial name
- NCT01673529
- Testing
- SB705498
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cough
Effect of Electronic Cigarette Use on Cough Reflex Sensitivity
Although electronic cigarettes (e-cigs) are now widely used, very little information exists regarding the effect of electronic cigarette use (vaping) on the respiratory system.
- Trial name
- NCT02203162
- Testing
- electronic cigarette exposure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
TRPV1 Protein, Human, Capsaicin
Esophageal capsaïcin Infusion and Mucosal Integrity
Reflux is common, especially after large meals. In general, this can do no harm. However, if reflux occurs often and causes troublesome symptoms and or complications, it is called gastroesophageal reflux disease (GERD).
- Conditions
- TRPV1 Protein, Human, Capsaicin, Electric Impedance, Esophagus
- Trial name
- NCT02603783
- Testing
- Capsaicin
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
The Effect of Capsaicin-induced Pain on Homeostatic Plasticity in Healthy Human Participants
People suffering from chronic pain exhibit changes in the way the central nervous system processes pain. Some of the changes in the central nervous system are associated with how the brain adapts to the process of different…
- Trial name
- NCT04485689
- Testing
- Capsaicin Topical - alone, Capsaicin Topical - ice
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Rhinitis
A Study To Assess The Effect Of SB-705498 In A Capsaicin Challenge Model
This study is designed to look at the affect of SB-705498 on rhinitis symptoms, as induced by capsaicin challenge
- Trial name
- NCT00731250
- Testing
- SB-705498, Caspaicin
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nonallergic Irritant Rhinitis
Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis
The proposed study seeks to investigate the effect of intranasal capsaicin treatment in patient with Non-allergic irritant rhinitis (NAIR), as well as evaluate optical rhinometry (ORM) as a means to quantify symptomatic…
- Trial name
- NCT02493257
- Testing
- Capsaicin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Ipsi- and Contralateral Hypoesthesia
A Human Experimental Model for Neuropathic Pain Using Combined Application of Capsaicin and Local Anesthetics
Main of the present study was to develop a model of concomitant C-fibre block and sensitization eliciting spontaneous pain as well applying topical capsaicin and local anesthetics (LA) to examine the sensory alterations after…
- Trial name
- NCT01540877
- Testing
- Application of capsaicin 0.6%, Application of local anesthetics (EMLA plaster), Application of 1 capsaicin 0.6% and 2. EMLA
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Pain
Study to Investigate the Pharmacodynamic Effects of IP2015 in Healthy Male Subjects Using the Intradermal Capsaicin Model
This is a Phase I, randomised, double-blind, placebo-controlled, 4-way crossover study to investigate the PD effects, safety, tolerability and PK/PD correlation of two single oral dose levels of IP2015 compared to 300 mg…
- Trial name
- NCT05181852
- Testing
- IP2015, dose 1, IP2015, dose 2, Pregabalin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Initiator Pharma
Irritable Bowel Syndrome, Colonic Diseases, Functional
fMRI and Visceral Perception Upon Capsaicin Infusion
Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD).
- Conditions
- Irritable Bowel Syndrome, Colonic Diseases, Functional, Dyspepsia, Gastrointestinal Diseases
- Trial name
- NCT02551029
- Testing
- Capsaicin
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Chemotherapy-induced Peripheral Neuropathy
The Role of TRP Channels in CIPN
Part I: Evaluating the increase in dermal blood flow upon topical application of cinnamaldehyde and capsaicin on the fingers in healthy, male volunteers.
- Trial name
- NCT04415892
- Testing
- Cinnamaldehyde and capsaicin
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Volunteers
Capsaicin on Salty Gustatory Cortices
Excess dietary salt intake is closely associated with the development of hypertension and cardiocerebral vascular diseases. Preference of high salt diet might involve salty gustatory cortices change.
- Trial name
- NCT01974037
- Testing
- Capsaicin, NaCl
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu