Clinical trials: Capsaicin
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Small Fiber Neuropathy
Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study
Small fiber neuropathy (SFN) is a common disorder, which has a profound negative impact on quality of life because of severe neuropathic pain.
- Trial name
- NCT02537951
- Testing
- AFI microscope, negative control 1: lidocaine/prilocaine, negative control 2: 8% capsaicin
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Chronic Cough, Bronchiectasis
ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis
This is a randomized, cross-over, single-blind trial. Eligible patients will be randomly assigned to undergo either capsaicin or adenosine triphosphate (ATP) cough provocation test, followed by a washout period of 2 to 14 days.
- Trial name
- NCT03638063
- Testing
- Adenosine Triphosphate, capsaicin
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Healthy
Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects
The purpose of this study is; to determine the pharmacodynamic (PD) effects of ICA-105665 using the intradermal (ID) capsaicin model in healthy male subjects, and to investigate the effect of ICA-105665 on inflammatory…
- Trial name
- NCT00962663
- Testing
- ICA-105665, Ibuprofen
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Effect of Nalbuphine and Naloxone on Experimentally Induced Skin Sensitivity
In previous clinical studies of post-surgical pain the investigators found that nalbuphine (Nubain), a narcotic pain killer, relieves pain more effectively when combined with low-dose naloxone (Narcan), a drug that is used to…
- Trial name
- NCT00947284
- Testing
- nalbuphine plus naloxone, nalbuphine plus saline, naloxone plus saline
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability
An altered permeability has been proposed to play an important role in the pathogenesis of several gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease.
- Trial name
- NCT01667523
- Testing
- Capsaicin, Cinnamaldehyde
- Where
- Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pain
High Definition Transcranial Direct Current Stimulation Motor Cortex Versus Insula
Brain stimulation is a technique that can alter cortical function and thus be suitable for treating pain. This is especially when pain is chronic and associated with functional and even structural reorganization of the central…
- Trial name
- NCT03216707
- Testing
- HD tDCS active motor cortex, HD tDCS active insula cortex, Capsaicin cream
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University