Clinical trials: Carbon Dioxide Pressure
Colorectal Surgery, Benign or Malignant Rectal or Colon Tumors
Laparoscopic Colorectal Surgery Using Low-pressure Combined With Warm and Humidified Carbon Dioxide Insufflation
To improve post-operative recovery, medical device was developed combining low-pressure pneumoperitoneum and heated and humidified Carbon Dioxide (95˚F \& 95% RH) during laparoscopic surgery to reduce the harmful effects of…
- Trial name
- PAROS3 (NCT05934981)
- Testing
- Laparoscopic surgery under low pressure and warm and humidified CO2 Insufflation, Laparoscopic surgery under low pressure and conventional Insufflation
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Bordeaux Colorectal Institute Academy
Colonoscopy
Transcutaneous Measurement of Carbon Dioxide Versus Current Sedation Practices in Sedated Patients
Does transcutaneous carbon dioxide partial pressure (TcCO2) monitoring detect hypoventilation prior to current sedation monitoring practices in order to prevent hypoxemia in sedated patients undergoing colonoscopies?
- Trial name
- NCT01060709
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- University Medical Center Groningen
Laparoscopic Surgery, Trendelenburg Position
Trend Correlation Between End-Tidal and Arterial Carbon Dioxide During Laparoscopic Surgery in Trendelenburg Position
In this study, we want to find out whether a person's "end-tidal carbon dioxide" (ETCO₂)-a value measured from the air they breathe out-accurately reflects the amount of carbon dioxide in their blood, called "arterial carbon…
- Trial name
- NCT06838078
- Volunteers
- 79 people
- Sponsor
- Koç University
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- high-intensity ventilation strategy, OSA-targeted ventilation strategy
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Blood Gas Monitoring, Transcutaneous
Effect of PEP on Oxygen Saturation and Carbon Dioxide After Abdominal Surgery
Positive expiratory pressure( PEP) is routinely given to patients after surgery in order to improve lung function and oxygen saturation.
- Trial name
- NCT03176589
- Testing
- positive expiratory pressure (PEP), Deep breathing maneuvers
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Chronic Obstructive Pulmonary Disease
Development of the Partial Pressure of Carbon Dioxide During Exercise and at Night in Patients With Chronic Obstructive Pulmonary Disease (COPD) IV
The aim of this study is to investigate the development of partial pressure of carbon dioxide during the 6-min walking test and during night in Chronic Obstructive Pulmonary Disease (COPD)-patients (GOLD stage IV).
- Trial name
- NCT01696916
- Testing
- 6-minute walking test
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Optic Nerve Sheath Diameter, Laparoscopic Nephrectomy
Effect of Carbon Dioxide Pressure on Optic Nerve Sheath Diameter in Laparoscopic Transperitoneal Nephrectomy
Nephrectomy is a surgical procedure performed for various indications, and with the development and increasing availability of advanced diagnostic techniques, its incidence has been rising.
- Trial name
- Lap Optic Nerv (NCT07262125)
- Testing
- Optic Nerve Sheath Diameter Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Conscious Sedation Failure During Procedure
Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy
Flexible bronchoscopy (FB) is a fundamental procedure for the diagnosis and treatment of respiratory diseases. Although midazolam is the recommended sedative agent by most guidelines, propofol has gained popularity due a short…
- Trial name
- NCT02820051
- Testing
- Transcutaneous CO2 monitor, Midazolam, Propofol
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Septic Shock, Fluid Resuscitation
Critical Closing Pressure and PCO₂ Gap in Fluid Resuscitation for Septic Shock
This study is based on the following key hypotheses: PvaCO₂ (Venous-to-Arterial CO₂ Gap) Hypothesis: Changes in PvaCO₂ (ΔPvaCO₂) following fluid resuscitation correlate with changes in cardiac output (CO) and can serve as a…
- Conditions
- Septic Shock, Fluid Resuscitation, Tissue Perfusion Pressure, Carbon Dioxide Pressure
- Trial name
- NCT07043192
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College
Ventilatory Depression
Correlation of ETCO2 to PaCO2 Measured by Sentri Nasal Cannula
Sampling end tidal gas via nasal prong has been shown to be a noninvasive and reliable method of monitoring end-tidal CO2 in spontaneously breathing patients.
- Trial name
- NCT03374644
- Testing
- SentriTM ETCO2 adult nasal cannula
- Volunteers
- 40 people
- Sponsor
- University of Malaya
Laparoscopic Hysteretctomy With Promontofixation
Impacts of Intraperitoneal Pressure and CO2 Gas on Surgical Peritoneal Environment
Use lay language. The primary purpose is to compare the impacts of intraperitoneal pressure (8mmHg versus 12 mmHg) and CO2 gas (cool, dry CO2 gas versus warmed, humidified CO2 gas) on gene expression in peritoneal tissues during…
- Trial name
- NCT01887028
- Testing
- Fisher and Paykel Humidifier (MR860AEU)
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Clermont-Ferrand
Gastrointestinal Neoplasms
Cerebral Blood Flow During Propofol Anaesthesia
General anaesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered during anaesthesia to maintain blood pressure.
- Trial name
- NCT02951273
- Testing
- Study of cerebral blood flow
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Esophageal Neoplasms
Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and…
- Trial name
- NCT02330536
- Testing
- Insufflation of carbon dioxide (CO2)
- Volunteers
- 232 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Stroke, Acute, Hemorrhage
Feasibility of Improving Cerebral Autoregulation in Acute Intracerebral Haemorrhage
In the UK, 23,000 (15%) of the 150,000 people who suffer a stroke each year have bleeding in the brain, also referred to as acute intracerebral haemorrhage (ICH).
- Conditions
- Stroke, Acute, Hemorrhage, Cerebral Brain Hemorrhage, Blood Pressure
- Trial name
- BREATHE-ICH (NCT03324321)
- Testing
- Hypocapnia via Hyperventilation Protocol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Leicester
Postoperative Outcome, Whipple Procedures
Veno-arterial CO2 Pressure Difference to Arterio-venous O2 Difference Ratio & Blood Lactate Levels Are Predictors of Postoperative Outcome in Whipple Procedures
Whipple surgery is a complex abdominal procedure associated with a high risk of hemodynamic instability and splanchnic hypoperfusion leading to anastomotic leaks, delayed gastric emptying, and organ dysfunction Traditional…
- Trial name
- NCT07306845
- Testing
- predictors of postoperative outcome in Whipple Procedures
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Hypercapnia
Changes in Capillary Carbon Dioxide Partial Pressure (pCO2) While Wearing FFP2 / FFP3 Masks
The aim of this study is to determine whether there are any changes in the carbon dioxide partial pressure in medical staff while wearing a filtering face piece (FFP) 2 or FFP3 mask.
- Trial name
- NCT04980820
- Testing
- No mask, Filtering face mask 2 (FFP2), Filtering face mask 3 (FFP3)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Surgical Procedure, Unspecified
Sugammadex: Effect on the Awareness Monitoring and Hemodynamics
Sugammadex is used to reverse the neuromuscular blocking effect of steroid neuromuscular blockers. Its cardiovascular effects and effect on brain cortex, if any, may be associated to the reversal of the neuromuscular block.
- Trial name
- NCT01301261
- Testing
- sugammadex, Sugammadex 4 mg/kg, Sugammadex 16mg/kg
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Respiratory Failure
Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children
This study assesses the feasibility of digital data collection for a randomized controlled trial in a quaternary pediatric intensive care unit and the effect of two commonly used mechanical ventilation modes on gas exchange (CO2)…
- Trial name
- CoCO2 (NCT05843123)
- Testing
- Respiratory support a, Respiratory support b
- Where
- Switzerland
- Volunteers
- 59 people
- Sponsor
- University Children's Hospital, Zurich
Multiple Trauma
Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial…
- Trial name
- NCT02727946
- Testing
- optimal resuscitation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Out-of-Hospital Cardiac Arrest
Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation
The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and effect on brain injury markers of targeting low or high normal arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2) and…
- Trial name
- COMACARE (NCT02698917)
- Testing
- Low normal PaCO2, High normal PaCO2, Low normal PaO2
- Where
- 7 sites in Denmark, Finland
- Volunteers
- 123 people
- Sponsor
- Helsinki University Central Hospital