Clinical trials: Carcinoma of Prostate (Disorder)
Prostate Cancer
Prognostic Factors in Prostate Cancer for Patients Treated by Watchful Waiting
The Trans-Atlantic Prostate Group (TAPG) was established to examine the hypothesis that through a detailed retrospective analysis of outcome in a group of men with clinically localised prostate cancer at diagnosis, variables such…
- Trial name
- TAPG (NCT03912883)
- Volunteers
- 3,350 people
- Sponsor
- Queen Mary University of London
Prostate Cancer
Patient-Reported Erectile Recovery and Quality of Life Outcomes With Lyopreserved Placental Tissue Applied Directly Over Neurovascular Bundle During Nerve Sparing Radical Prostatectomy Versus Standard of Care
Surgical implantation of Lyopreserved Placental Tissue (LPT) is FDA approved and has been used extensively in wound care. The use is expanding and more recently, LPT has been used in the management of diabetic foot ulcers, acute…
- Trial name
- NCT05366842
- Testing
- Stravix lyopreserved placental tissue (LPT), Radical prostatectomy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Prostate Cancer
Trial of Iressa in Prostate Cancer Patients
This study is being carried out to see if ZD1839 is effective in treating prostate cancer after being diagnosed with an early rising PSA (prostate specific antigen) following surgery.
- Trial name
- NCT00265070
- Testing
- Gefitinib
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Hyperalgesia, Pain
Effects of N-Methyl-D-Aspartate (NMDA)-Receptor Antagonism on Hyperalgesia, Opioid Use, and Pain After Radical Prostatectomy
The primary aim is to determine whether perioperative NMDA-receptor antagonism has differential effects on postoperative pain, hyperalgesia and morbidity in younger and older patients.
- Conditions
- Hyperalgesia, Pain, Prostate Cancer
- Trial name
- NCT00188383
- Testing
- Amantadine
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- University Health Network, Toronto
Metastatic Prostate Cancer, Prostatic Neoplasms
18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer
Background: Prostate cancer is the second leading cause of cancer deaths in American men. Few options exist to create images of this type of cancer.
- Conditions
- Metastatic Prostate Cancer, Prostatic Neoplasms, Prostate Cancer, Prostatic Cancer
- Trial name
- NCT03173924
- Testing
- 18F-NaF, 18F-DCFPyL, 18F-FDG
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Assessing The Impact Of Incorporating Charlson Comorbidity Scores On Patient Anxiety And Satisfaction
The purpose of this study was to determine whether providing patients with life expectancy (LE) information in the form of their Prostate Cancer Comorbidity Index (PCCI) scores impacted their decisional conflict or anxiety about…
- Trial name
- NCT03950180
- Testing
- Prostate Cancer Comorbidity Index (PCCI) score
- Volunteers
- 277 people
- Sponsor
- Benaroya Research Institute
Cancer, Breast Cancer
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
Add-Aspirin aims to assess whether regular aspirin use after standard curative therapy can prevent recurrence and improve survival in individuals with non-metastatic common tumours.
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02804815
- Testing
- Aspirin 100mg, Aspirin 300mg
- Where
- 82 sites in Ireland, United Kingdom
- Volunteers
- 11,000 people
- Sponsor
- University College, London
Prostate Cancer
Effects of Anesthetic Technique on Immune and Inflammatory Systems Following Radical Prostatectomy
Several recently published retrospective studies show that regional anaesthesia (RA) can reduce cancer-related mortality following surgical treatment of colorectal, breast and prostate cancers and malignant melanoma.
- Trial name
- AIMS (NCT01367418)
- Testing
- Patient controlled analgesia (PCA), Thoracic Epidural Analgesia (TEA)
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Örebro University, Sweden
Prostate Cancer
Circulating Tumour Cells as Biomarkers to Predict Prostate Cancer Metastasis for Treatment Stratification of Cancer
The goal of this study is to establish the value of Circulating Tumour Cell (CTC) positivity in predicting post-RP treatment failure, including BCR and new lesions detected by cancer imaging.
- Trial name
- C-ProMeta-1 (NCT05533515)
- Testing
- CTC Blood Test
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- Queen Mary University of London
Glioma, Glioma, Malignant
Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors
At the time of study termination, NUV-422-02 was a first-in-human, open-label, Phase 1 dose escalation study designed to evaluate the safety and efficacy of NUV-422.
- Conditions
- Glioma, Glioma, Malignant, Glioma, Mixed, Glial Cell Tumors
- Trial name
- NCT04541225
- Testing
- NUV-422
- Where
- 12 sites in United States
- Volunteers
- 74 people
- Sponsor
- Nuvation Bio Inc.
Prostate Cancer
Safety Study of Continued Enzalutamide Treatment In Prostate Cancer Patients
The purpose of this study is to determine if continued treatment with Enzalutamide is effective in patients with metastatic prostate cancer.
- Trial name
- PLATO (NCT01995513)
- Testing
- Enzalutamide, Abiraterone, Prednisone
- Where
- 95 sites in United States, Australia and 9 more
- Volunteers
- 509 people
- Sponsor
- Pfizer
Information Support
The Effect of Information Support Program on Self-efficacy of Prostate Cancer Patients During Hormonal Therapy
The incidence rate of prostate cancer has been increasing rapidly in China in recent years. However, a large number of studies have shown that, patients with prostate cancer during hormonal therapy generally face the imbalance of…
- Trial name
- NCT04340713
- Testing
- information support program
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Fudan University
Prostatic Neoplasms, Breast Cancer
Study With Modafinil in Patients Treated With Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer (MOTIF)
The primary objective is: To determine the efficacy of modafinil in the reduction of fatigue in patients with metastatic breast or prostate cancer undergoing docetaxel-based chemotherapy The secondary objectives are: To determine…
- Trial name
- NCT00917748
- Testing
- DOCETAXEL(XRP6976) + MODAFINIL, Modafinil
- Where
- Australia
- Volunteers
- 84 people
- Sponsor
- Sanofi
Prostate Cancer
Two-Dose Level Evaluation of NX-1207 for the Treatment of Low Risk, Localized (T1c) Prostate Cancer
This study is designed to evaluate the safety and efficacy of a single injection of NX-1207 for the treatment of biopsy-confirmed low risk localized (T1c) prostate cancer in patients currently undergoing active surveillance.
- Trial name
- NCT01620515
- Testing
- NX-1207 2.5 mg, NX-1207 15 mg
- Where
- 23 sites in United States
- Volunteers
- 141 people
- Sponsor
- Nymox Corporation
Prostate Cancer
Prospective Multicentre Cohort Study PROREPAIR-B (mCRPC)
PROREPAIR is a prospective multicenter observational cohort study of unselected patients with metastatic Castration Resistant Prostate Cancer (mCRPC) with unknown germline mutational status at study entry and who are candidates…
- Trial name
- NCT03075735
- Volunteers
- 408 people
- Sponsor
- Centro Nacional de Investigaciones Oncologicas CARLOS III
Prostate Cancer
A Pilot Study Evaluating Oral Triamcinalone in Patients With Androgen Independent Prostate Cancer
The primary purpose of this study is to evaluate the ability of oral triamcinalone given twice a day to patients with androgen independent prostate cancer to produce a sustained biochemical response.
- Trial name
- NCT00186108
- Testing
- Oral Triamcinalone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm
A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer
This phase II trial tests the how well a precision medicine approach (serial measurements of molecular and architectural response to therapy [SMMART])-adaptive clinical treatment [ACT]) works in treating patients with sarcoma…
- Conditions
- Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma, Advanced Pancreatic Carcinoma
- Trial name
- NCT06630325
- Testing
- Abemaciclib, Biopsy, Bone Scan
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OHSU Knight Cancer Institute
Prostate Cancer
Markers for Early Detection of Prostate Cancer
This study will determine whether certain gene alterations can serve as markers for early detection of prostate cancer. Prostate cancer is often diagnosed by detecting high levels of a protein called prostate-specific antigen…
- Trial name
- NCT00340717
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Financial Toxicity, Cancer
DISCO: A Patient Intervention to Reduce the Financial Burden of Cancer
The DISCO App is designed to improve, during the interaction, patient active participation and patient-initiated oncologist treatment cost discussions, and, in the short term, patient's treatment cost knowledge, self-efficacy for…
- Conditions
- Financial Toxicity, Cancer, Question Prompt List, Breast Cancer
- Trial name
- DISCO (NCT04766190)
- Testing
- Group 2: The DISCO App, Group 1: Usual Care, Group 3: The DISCO App + Booster
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Lauren Hamel
Prostate Cancer
Race-related Alternative Splicing: Novel Targets in Prostate Cancer
Data from evaluating prostate cancer (PCa) biopsy tissue from AA and white patients has led to the discovery of alternative splicing as a novel molecular mechanism underlying more aggressive PCa in AA men.
- Trial name
- PCaP splicing (NCT03424213)
- Testing
- No interventions - retrospective data collection
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Duke University
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