Clinical trials: Carcinoma of the Rectum
Colorectal Cancer
Simvastatin and Panitumumab in Treating Patients With Advanced or Metastatic Colorectal Cancer
RATIONALE: Simvastatin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways.
- Trial name
- NCT01110785
- Testing
- panitumumab, simvastatin, laboratory biomarker analysis
- Where
- 4 sites in Netherlands
- Volunteers
- 46 people
- Sponsor
- Leiden University Medical Center
Rectal Cancer, Advanced Cancer
Complete Versus Partial Preservation of Denonvilliers' Fascia on Urogenital Function in Locally Advanced Rectal Cancer
Total mesorectal resection (TME) is the standard surgical method for locally advanced rectal cancer, which significantly reduces the local recurrence rate. However, the incidence of urogenital dysfunction is higher.
- Trial name
- NCT04672603
- Testing
- Complete Preservation of Denonvilliers' Fascia
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer, Rectal Carcinoma
A Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophylactic Ileostomy in the Treatment of Low Rectal Cancer After Internal Sphincter Resection
This study targets patients undergoing ultra-low rectal cancer surgery, which requires internal sphincter resection for sphincter-saving procedures.
- Trial name
- STAR-TAR (NCT06662643)
- Testing
- Delayed transanal pull-through anastomosis, Direct Anastomosis Plus Prophylactic Ileostomy
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhongnan Hospital
Colo-rectal Cancer
The AIDPRO-CRC Trial
The AIDPRO-CRC trial aims to improve outcomes for patients undergoing surgery for colorectal cancer by using artificial intelligence (AI) to assist surgeons in risk assessment.
- Trial name
- AIDPRO-CRC (NCT06645015)
- Testing
- AI augmented risk-stratification, Expert-based Risk-stratification
- Where
- 8 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Zealand University Hospital
Rectal Neoplasms
Robotic Assisted Transanal Total Mesorectal Excision Surgery for Rectal Cancer in Low Site
To investigates the feasibility, practicability, safety and subjective as well as functional outcome of Robotic transanal total mesentery excision for rectal cancer in low site.
- Trial name
- NCT03422835
- Testing
- R-TME, R-TaTME
- Volunteers
- 50 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Rectal Cancer, Organ-Space Surgical Site Infection
Organ/Space Surgical Site Infection and Recurrence and Survival in Rectal Cancer Surgery
In rectal cancer surgery, the organ/space surgical site infection (O/S-SSI) has an impact on patient's prognosis. Its influence in the oncologic outcomes remains controversial.
- Trial name
- VINCat_PDO_2 (NCT06382415)
- Where
- Spain
- Volunteers
- 3,826 people
- Sponsor
- Hospital de Granollers
Solid Tumor, Adult, Colorectal Cancer
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
The goal of this study is to test A2B395, an allogeneic logic-gated Tmod™ CAR T-cell product in subjects with solid tumors including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell…
- Conditions
- Solid Tumor, Adult, Colorectal Cancer, Non-Small Cell Lung, NSCLC (Non-small Cell Lung Cancer)
- Trial name
- DENALI-1 (NCT06682793)
- Testing
- A2B395, xT CDx with HLA-LOH assay
- Where
- 10 sites in United States
- Volunteers
- 240 people
- Sponsor
- A2 Biotherapeutics Inc.
Lower Abdominal Surgery, Pelvic Surgery
Objective to Evaluate the Safety and Effectiveness of LED Light Source System for Endoscopy in Ureteral Radiography
This clinical trial is a prospective, multi-center, single-blind, parallel, randomized controlled superiority clinical trial. The trial will be carried out in 5 centers, involving 120 subjects as estimated who will be divided…
- Trial name
- IRIS (NCT04561414)
- Testing
- LED light source system for endoscope, Ureteral stent (Cook Ireland Ltd.)
- Where
- 4 sites in China
- Sponsor
- Stryker Orthopaedics
Bowel Dysfunction, Rectal Cancer
A Prospective Multi-Center Research on Bowel Dysfunction After Sphincter Preservative Surgery
This research plans to collect rectal cancer patients after sphincter-preserving surgery from 14 institutions in China mainland, observe the incidence and risk factors about bowel dysfunction after operation.
- Trial name
- PMCRBDSPS (NCT03009747)
- Volunteers
- 460 people
- Sponsor
- Peking University People's Hospital
Rectal Neoplasms, Robotic Surgery
Clinical Outcomes and Prognostic Factors of Robotic Assisted Rectal Cancer Resection Alone vs. Robotic Rectal Cancer Resection With Natural Orifice Specimen Extraction
Robotic rectal cancer resection with natural orifice extraction is a recently developed minimally invasive surgery for patients with rectal cancer. However, it's safety and feasibility remain undiscussed and controversial.
- Conditions
- Rectal Neoplasms, Robotic Surgery, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT04265417
- Testing
- Robotic Assisted Rectal Cancer Resection Alone, Robotic Assisted Rectal Cancer Resection With Natural Orifice Specimen Extraction
- Volunteers
- 98 people
- Sponsor
- Taiyuan Li
Anal Cancer, Colorectal Cancer
Octreotide in Preventing or Reducing Diarrhea in Patients Receiving Chemoradiotherapy for Anal or Rectal Cancer
RATIONALE: Octreotide may be effective in preventing or controlling diarrhea in patients who are undergoing chemoradiotherapy for anal or rectal cancer. It is not yet known whether octreotide is effective in treating diarrhea.
- Conditions
- Anal Cancer, Colorectal Cancer, Drug/Agent Toxicity by Tissue/Organ, Radiation Enteritis
- Trial name
- NCT00075868
- Testing
- octreotide acetate
- Where
- 112 sites in United States
- Volunteers
- 233 people
- Sponsor
- Radiation Therapy Oncology Group
Colorectal Carcinoma
Laparoscopic Assisted Versus Open Resection for Colorectal Carcinoma
The aim of the investigators' randomized trial is to compare the short-term clinical outcome and survival between laparoscopic-assisted and open resection of colorectal carcinoma.
- Trial name
- NCT00485316
- Testing
- Laparoscopic assisted resection of colorectal carcinoma
- Where
- China
- Sponsor
- Chinese University of Hong Kong
Rectal Cancer
Preoperative Assessment of Mesorectal Lymph Nodes by Dual Energy CT. PUMK-DECT
Endpoints subproject 1: To develop a reproducible method for the detection of lymph nodes by DECT in operation specimens from rectal resection for cancer.
- Trial name
- NCT02592304
- Testing
- Dual energy computed tomography
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Odense University Hospital
Colorectal Cancer, Colon Cancer
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
The study attempts to quantify the relative risks for mortality, anastomotic leakage and other early and late postoperative complications, recurrence rate, cancer-specific survival, recurrence-free survival after colorectal…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancer, Colorectal Adenocarcinoma
- Trial name
- NCT06050447
- Testing
- Right hemicolectomy, Left hemicolectomy, Sigmoid colon resection
- Where
- Russia
- Volunteers
- 1,200 people
- Sponsor
- Immanuel Kant Baltic Federal University
Rectal Cancer
Quality of Life in Patients With Rectal Cancer Receiving Total Mesorectal Excision With or Without Stoma
The goal is to evaluate whether the renunciation of a diverting stoma in patients with adjuvant chemotherapy after low anterior resection with total mesorectal excision (TME) and neoadjuvant chemoradiotherapy leads to a better…
- Trial name
- NCT03487484
- Testing
- Quality of Life Questionnaire for gastrointestinal tract, Quality of Life Questionnaire, Faecal Incontinence Score
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Basel, Switzerland
Pancreatic Cancer, GastroEsophageal Cancer
Supportive Oncology Care At Home RCT
This research study is evaluating a program that entails remote monitoring and home-based care for people with cancer who are receiving chemotherapy, radiotherapy, or chemoradiotherapy.
- Conditions
- Pancreatic Cancer, GastroEsophageal Cancer, Rectal Cancer, Head and Neck Cancer
- Trial name
- NCT04544046
- Testing
- Supportive Oncology Care at Home, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Esophageal Cancer, Gastric Cancer
Prospective Analysis of Robot-Assisted Surgery
The robot-assisted surgery allows three-dimensional view, detailed access of small structures, depth perception and articulated movements with wide latitude.
- Conditions
- Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Rectal Cancer
- Trial name
- NCT02292914
- Testing
- Robot-assisted surgery, Conventional Surgery
- Where
- Brazil
- Volunteers
- 1,120 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Rectal Cancer, Anastomotic Leakage
Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection
The goal of this clinical trial is to learn if somatostatin plus a clear liquid diet can help prevent severe leakage after rectal cancer surgery in adults with low or mid rectal cancer who are scheduled to have ultra-low anterior…
- Trial name
- SC-Stoma (NCT07605611)
- Testing
- Somatostatin, Clear Liquid Diet, Prophylactic Diverting Stoma
- Where
- 3 sites in China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
This phase I clinical trial is studying the side effects and best dose of giving gamma-secretase inhibitor RO4929097 and cediranib maleate together in treating patients with advanced solid tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT01131234
- Testing
- Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Colo-rectal Cancer, Shared Decision Making
Shared Decision-Making for Colorectal Cancer Screening in High-Risk First-Degree Relatives Aged 40-49
The primary objective of this study was to evaluate the impact of a constructed shared decision (SDM) intervention (offering an option between colonoscopy and immunochemical collapsible occult blood testing (fecal immunochemical…
- Conditions
- Colo-rectal Cancer, Shared Decision Making, Patient Decision Aid
- Trial name
- NCT07503847
- Testing
- Colonoscopy, Shared Decision-Making
- Where
- Taiwan
- Volunteers
- 2,286 people
- Sponsor
- National Taiwan University Hospital
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