Clinical trials: Carcinomas
Carcinoma, Non-Small-Cell Lung
Concomitant Chemo-radiotherapy in Locally Advanced Non Small Cell Lung Cancer
Feasibility of pragmatic concomitant chemo-radiotherapy association with 1 cycle of Induction chemotherapy, weekly chemo-radiotherapy, and consolidation chemotherapy.
- Trial name
- BIB 01 (NCT00210171)
- Testing
- Toxicity : Time to progression, 1 and 2 years survival
- Where
- 7 sites in France
- Sponsor
- Institut Bergonié
Hepatocellular Carcinoma
Pembrolizumab Plus Y90 Radioembolization in HCC Subjects
This is an open-label multi-center trial designed to evaluate the efficacy as well as the safety of combining pembrolizumab with Yttrium-90 (Y90) radioembolization in subjects with poor prognosis (high risk) HCC not eligible for…
- Trial name
- NCT03099564
- Testing
- Pembrolizumab, Y90 radioembolization
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Ashwin Somasundaram
Hematuria, Urothelial Carcinoma
STRATA: Safe Testing of Risk for AsymptomaTic MicrohematuriA
To evaluate the clinical utility associated with the integration of Cxbladder into the evaluation of subjects presenting with hematuria for evaluation of urothelial carcinoma (UC) without compromising detection of UC.
- Trial name
- NCT03988309
- Testing
- Cxbladder
- Where
- 12 sites in United States, Canada
- Volunteers
- 554 people
- Sponsor
- Pacific Edge Limited
Castration-Resistant Prostate Carcinoma, Prostate Adenocarcinoma Without Neuroendocrine Differentiation
Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer
This phase II trial studies how well apalutamide and abiraterone acetate work in treating participants with castration resistant prostate cancer that has spread to other places in the body (metastatic).
- Conditions
- Castration-Resistant Prostate Carcinoma, Prostate Adenocarcinoma Without Neuroendocrine Differentiation, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT03360721
- Testing
- Abiraterone Acetate, Apalutamide, Prednisone
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Carcinoma, Renal Cell
Pazopanib/DCE-MRIs in Renal Cell Carcinoma (RCC)
All patients who participate in this study will receive pazopanib. Pazopanib is an oral drug (pill) that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced kidney cancer.
- Trial name
- NCT01221506
- Testing
- Pazopanib, DCE-MRI and Quantitative Doppler Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Renal Cell Carcinoma, Tumor, Solid
Biomarkers of Renal Cancer
The aim of the present study is the identification, in liquid biopsies, of a new molecular panel able to discriminate renal cancer patients from controls, to discriminate patients with a malignant lesion from those with a benign…
- Conditions
- Renal Cell Carcinoma, Tumor, Solid, Oncocytoma, Angiomyolipoma
- Trial name
- BRC (NCT05785052)
- Where
- 4 sites in Italy, Spain
- Volunteers
- 1,000 people
- Sponsor
- Biorek S.R.L.
Hepatobiliary Cancer, Cholangiocarcinoma
Senior Adult Hepatobiliary Prehab Study
The purpose of the study is to evaluate an exercise program for individuals with hepatobiliary cancer planning for surgery.
- Conditions
- Hepatobiliary Cancer, Cholangiocarcinoma, Liver Metastases
- Trial name
- NCT05921552
- Testing
- Resistance Training, Aerobic Training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
NSCLC, Stage I
Ablative STEreotactic RadiOtherapy wIth Durvalumab (MEDI4736)
This is a randomized multicentre open label phase II study of Durvalumab following Stereotactic Body Radiotherapy (SBRT) in patients with T1-2N0M0 NSCLC.
- Trial name
- ASTEROID (NCT03446547)
- Testing
- Durvalumab
- Where
- 15 sites in Finland, Norway and 1 more
- Volunteers
- 106 people
- Sponsor
- Vastra Gotaland Region
Renal Cell Carcinoma
Anesthesia and Cancer Study: Renal Cell Carcinoma
This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy.
- Trial name
- NCT04503148
- Testing
- Propofol, Inhaled General Anesthetics
- Where
- South Korea
- Volunteers
- 562 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma
A Study of Mapatumumab in Combination With Sorafenib in Subjects With Advanced Hepatocellular Carcinoma
The purpose of this study is to evaluate the safety and tolerability of escalating doses of mapatumumab in combination with sorafenib in subjects with advanced Hepatocellular Carcinoma who are positive for hepatitis B surface…
- Trial name
- HCC (NCT00712855)
- Testing
- mapatumumab, sorafenib
- Where
- 6 sites in United States
- Volunteers
- 23 people
- Sponsor
- Human Genome Sciences Inc., a GSK Company
Bladder Cancer
Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer
The purpose of this study is to explore a treatment that potentially enhances the delivery of chemotherapy to tumors in participants with superficial bladder cancer.
- Trial name
- NCT00318643
- Testing
- Mitomycin C, Chemophase
- Where
- 5 sites in United States
- Volunteers
- 27 people
- Sponsor
- Halozyme Therapeutics
Advanced Nasopharyngeal Carcinoma
GP-induced Chemotherapy Combined With IMRT and TPF-induced Chemotherapy Combined With IMRT in the Treatment of Distant Metastatic Nasopharyngeal Carcinoma
Mainly compared with GP induction chemotherapy combined with IMRT and TPF induction chemotherapy combined with IMRT in the treatment of nasopharyngeal carcinoma, the cure rate, remission rate, treatment of distant metastases and…
- Trial name
- NCT03723343
- Testing
- GP+IMRT, TPF+IMRT
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Guiyang Medical University
Lung Cancer Non Small Cell
A Study of Lymph Node Metastatic Pattern Based Incorporating Tumor Location, GGO Components and Size for Non-small Cell Lung Cancer
The goal of this observational study is to learn about in invasive non-small cell lung cancer patients who underwent pulmonary resection with systematic lymph node dissection from April 2008 to July 2022 .
- Trial name
- NCT06161935
- Testing
- no intervention
- Volunteers
- 7,067 people
- Sponsor
- Fudan University
Carcinoma in Situ, Bladder Cancer
Intravesical AD 32 (Valrubicin) in Patients With Carcinoma in Situ (CIS) of the Bladder Who Have Failed or Have Recurrence Following Treatment With Bacillus Calmette-guerin (BCG)
This is a Phase II/Phase III study of intravesical AD 32 (valrubicin) in patients with carcinoma in situ (CIS) who have been previously treated with intravesical Bacillus Calmette-Guerin (BCG) for CIS and in whom recurrence or…
- Trial name
- Bladder Cancer (NCT01316874)
- Testing
- Valrubicin, 800 mg
- Where
- 39 sites in United States
- Volunteers
- 90 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Thymic Epithelial Tumor, Thymoma
Electrocautery Resection Combined With HITHOC for Thymic Epithelial Tumors With Pleural Metastasis
The goal of this observational study is to explore the effectiveness of electrocautery resection combined with hyperthermic intrathoracic chemotherapy (HITHOC) in patients with thymic epithelial tumors with pleural metastasis or…
- Conditions
- Thymic Epithelial Tumor, Thymoma, Thymic Carcinoma, Pleural Metastasis
- Trial name
- NCT07328074
- Testing
- Patients with thymic epithelial tumors with pleural metastasis or recurrence who undergo extended thymectomy with electrocautery resection of pleural metastases followed by two cycles of hyperthermic, Hyperthermic Intrathoracic Chemotherapy (HITHOC)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Extensive-stage Small-cell Lung Cancer
Safety and Efficacy of Adebrelimab Plus Irinotecan Liposome (II) With or Without Famitinib in ES-SCLC Pre-treated With Immunotherapy
This is an open-label, randomized, multi-cohort, multi-center, phase Ib/II study to evaluate the safety and efficacy of Adebrelimab plus Irinotecan Liposome (II) with or without Famitinib in patients with extensive-stage small…
- Trial name
- NCT06332950
- Testing
- Adebrelimab, Irinotecan Liposome (II), Adebrelimab, Irinotecan Liposome (II), Famitinib
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Baohui Han
Nasopharyngeal Carcinoma
Olfactory Change After Chemo-radiotherapy for Nasopharyngeal Carcinoma
This is an observational cohort study aimed to explore the changes of olfactory function at multiple time points from baseline to 1 year after radiotherapy among the local advanced nasopharyngeal carcinoma patients.
- Trial name
- NCT05146050
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer (H&N)
Screening Psychosocial Distress in Head and Neck Cancer
This prospective, multicenter study aims to assess the presence of psychosocial distress using the Distress Thermometer in patients treated for head and neck cancer at the initiation of their speech-language therapy.
- Trial name
- DEP-VADS-ORTHO (NCT07851818)
- Testing
- Psychosocial distress screening using the Distress Thermometer
- Volunteers
- 80 people
- Sponsor
- Hôpital NOVO
Malignant Pleural Effusion, Nonsmall Cell Lung Cancer, Stage IV
A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC
This randomized phase II study compare survival outcomes and toxicity of malignant pleural effusion stage IV non small-cell lung cancer patients Intrapleural infusion chemotherapy in combination with concurrent thoracic radiation…
- Trial name
- NCT03987087
- Testing
- Radiation, Chemotherapy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Guizhou Medical University
Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer
Patients With Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis and potential progression to cirrhosis.
- Conditions
- Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer, Cancer Liver
- Trial name
- BILIFLEX (NCT07573514)
- Testing
- Reflex AMA and ANA testing
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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