Clinical trials: Carcinomas
Squamous Cell Carcinoma of the Oropharynx
HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
The study will evaluate the safety and effectiveness of a lower than standard dose of radiation for definitive or adjuvant treatment of head and neck squamous cell carcinomas.
- Trial name
- HN001 (NCT05962242)
- Testing
- Radiation Therapy
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Virginia
Lung Cancer
Study of Tissue Samples From Patients With Stage I Non-Small Cell Lung Cancer Enrolled on Research Study CALGB-140202
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
- Trial name
- NCT00990873
- Testing
- gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction
- Volunteers
- 100 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Intrahepatic Cholangiocarcinoma
Liver Transplantation for Early Intrahepatic Cholangiocarcinoma
Diagnosis of intrahepatic cholangiocarcinoma (iCCA) is increasingly common in patients with liver cirrhosis, but these patients are denied liver transplantation (LT) by most centres due to historically poor results.
- Trial name
- LT for iCCA (NCT02878473)
- Testing
- Deceased donor Liver Transplantation
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Non-Small-Cell Lung Cancer, Pleural Effusion, Malignant
Non-small Cell Lung Cancer Registry
This trial will evaluate two separate groups of patients with stage IIIB/IV non-small cell lung cancer. The objective of Group 1 is to investigate an FDA-approved drug in stage IIIB/IV non-small cell lung cancer patients that has…
- Trial name
- NCT00099541
- Testing
- zoledronic acid
- Where
- 101 sites in United States
- Volunteers
- 300 people
- Sponsor
- Novartis Pharmaceuticals
Esophageal Squamous Cell Carcinoma
Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma
The study aimed to evaluate the efficacy and safety of sitravatinib in combination with tislelizumab as a second- or third-line treatment for participants with locally advanced, unresectable, or metastatic esophageal squamous…
- Trial name
- NCT05461794
- Testing
- Sitravatinib, Tislelizumab, Docetaxel
- Where
- 31 sites in China
- Volunteers
- 96 people
- Sponsor
- BeiGene
Head and Neck Cancer, Islet Cell Tumor
Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Conditions
- Head and Neck Cancer, Islet Cell Tumor, Metastatic Cancer, Pheochromocytoma
- Trial name
- NCT00466856
- Testing
- octreotide acetate, yttrium Y 90 resin microspheres
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Hepatocellular Carcinoma, Programmed Cell Death 1
Real-world Study of Efficacy and Safety of ICIs and TKIs Therapy for HCC
China is a high-risk area of Hepatocellular Carcinoma (HCC). Although Chinese population accounts for 18.4% of the global population, the number of new HCC patients accounting for about half of the global, which seriously…
- Conditions
- Hepatocellular Carcinoma, Programmed Cell Death 1, Effects of Immunotherapy
- Trial name
- NCT05420922
- Testing
- Lenvatinib Oral Product, PD-1 inhibitor, Local treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Carcinoma, Non-Small-Cell Lung, Mesothelioma
Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma
This study will investigate the effect of oral LBH589 on dextromethorphan, a CYP2D6 substrate, and to assess safety and efficacy of oral LBH589 when used with this co-medication in advanced stage NSCLC or malignant pleural…
- Trial name
- NCT00535951
- Testing
- LBH589
- Where
- 5 sites in United States, Canada
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Solid Tumors Harboring NTRK Fusion
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3).
- Trial name
- NAVIGATE (NCT02576431)
- Testing
- BAY2757556 (Larotrectinib, Vitrakvi)
- Where
- 98 sites in United States, Argentina and 23 more
- Volunteers
- 215 people
- Sponsor
- Bayer
Breast Cancer, Invasive Breast Carcinoma
Tissue- and Serum-Derived Exosomal microRNAs as Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer
This prospective observational study aims to evaluate whether exosomal microRNA profiles derived from tumor tissue and blood serum are associated with pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in…
- Conditions
- Breast Cancer, Invasive Breast Carcinoma, Exosomal microRNA, Neoadjuvant Chemotherapy Response
- Trial name
- ExoTSS-BC (NCT07500129)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlas University
Hepatocellular Carcinoma
to Evaluate the Efficacy and Safety of MG4101(Ex Vivo Expanded Allogeneic NK Cell)
To see the safety and efficacy of injecting MG4101 as a secondary treatment after curative liver resection on the patient with advanced HCC who has high risk of recurrence.
- Trial name
- MG4101 (NCT02008929)
- Testing
- MG4101
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Samsung Medical Center
Renal Cell Carcinoma, Adrenal Carcinoma
VETC, Prognostic and Predictive Value in Renal Cell Carcinoma and Adrenal Carcinoma
Metastasis is the main cause of death in cancer patients and often epithelial-to-mesenchymal transition (EMT) is advocated as the basic mechanism.
- Trial name
- NCT04666220
- Testing
- VETC evaluation
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Humanitas Clinical and Research Center
Pancreatic Alpha Cell Carcinoma, Pancreatic Beta Islet Cell Carcinoma
Temozolomide and Pazopanib Hydrochloride in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors That Cannot Be Removed By Surgery
This phase I/II trial studies the side effects and best dose of temozolomide and pazopanib hydrochloride when given together and to see how well they work in treating patients with advanced pancreatic neuroendocrine tumors (PNET)…
- Conditions
- Pancreatic Alpha Cell Carcinoma, Pancreatic Beta Islet Cell Carcinoma, Pancreatic Delta Cell Carcinoma, Pancreatic G-cell Carcinoma
- Trial name
- NCT01465659
- Testing
- temozolomide, pazopanib hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Northwestern University
Hepatitis B, Hepatitis B, Chronic
Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity
In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease.
- Conditions
- Hepatitis B, Hepatitis B, Chronic, End Stage Liver Disease, Carcinoma, Hepatocellular
- Trial name
- NCT02148562
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Differentiated Thyroid Carcinoma
OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation
Thyroidectomy followed by administration of large activities of 131-iodine (131I) is the treatment of choice for differentiated thyroid carcinoma (DTC).
- Trial name
- NCT00439127
- Volunteers
- 28 people
- Sponsor
- Oncology Institute of Southern Switzerland
Hepatocellular Carcinoma
Study of Hepatocellular Carcinoma in Cirrhotic Patients
The project is based on a case-control study including cirrhotic patients with (200 cases) and without (400 controls) Hepatocellular carcinoma.
- Trial name
- CIRCE ProSpec (NCT01904942)
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Cancer
Dasatinib In Combination With Weekly Paclitaxel For Patients With Metastatic Breast Carcinoma CA 180 194
The purpose of this study is to find the highest dose of dasatinib that can be safely given to a patient when the drug is given in combination with the known anticancer drug paclitaxel.
- Trial name
- NCT00820170
- Testing
- Dasatinib and Paclitaxel
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Squamous Cell Carcinoma of the Head and Neck
A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer
This was a Phase 2a trial to investigate the safety and biological activity of the RIX-2 Regimen in patients with untreated, resectable squamous cell cancer of the head and neck (HNSCC).
- Trial name
- NCT00210470
- Testing
- IRX-2, Cyclophosphamide, Indomethacin
- Volunteers
- 27 people
- Sponsor
- Brooklyn ImmunoTherapeutics, LLC
Hepatocellular Carcinoma
TIPS Plus Cadonilimab in Advanced HCC with Tumor Thrombosis-associated Portal Hypertension:a Prospective, Single-arm, Phase II Study
The purpose of this study is to evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) plus Cadonilimab (a PD-1/CTLA-4 bispecific antibody) in advanced hepatocellular carcinoma (BCLC-C Stage)…
- Trial name
- NCT05882370
- Testing
- Cadonilimab, transjugular intrahepatic portosystemic shunt (TIPS)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fei Gao
Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma
TIL Therapy in cSCC and MCC
The purpose of this research study is to test the safety and effectiveness of a tumor-infiltrating lymphocyte (TIL) cellular therapy, also called LN-145 or lifileucel, and chemotherapy in combination with Interleukin-2 (IL-2) to…
- Conditions
- Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma, Skin Cancer
- Trial name
- NCT07288073
- Testing
- LN-145, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Karam Khaddour, MD, MS
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