Clinical trials: Cardiac
Pregnancy Related, Glucose, Low Blood
Interval Versus Continuous Exercise During Pregnancy
The objective of this randomized cross-over design was to investigate the fetal well-being and maternal glycemic response to an acute bout of aerobic high-intensity interval training (HIIT) and moderate-intensity continuous…
- Conditions
- Pregnancy Related, Glucose, Low Blood, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus, Fetal Blood Flow
- Trial name
- NCT05369247
- Testing
- High intensity Interval Training, Moderate Intensity Continuous Training
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cardiomyopathies
Diagnostic and Prognostic Role of Troponin and Brain Natriuretic Peptide in Pediatric Patients With Cardiomyopathy in Correlation to Echocardiography Findings
This study aims to assess the the role of cardiac biomarkers (troponin and ProBNP) in pediatric Patients with all types of cardiomyopathy in correlation with echocardiography findings .
- Trial name
- NCT06348732
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arrhythmia, Cardiac
Bioequivalence of RYTHMOL SR® Manufactured at Two Different Sites
Bioequivalence of propafenone hydrochloride capsules manufactured at two different sites
- Trial name
- NCT01956487
- Testing
- Propafenone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non Cardiac Chest Pain
The Evaluation of Effectiveness Between Empirical and Guided Therapy for Unexplained Non-Cardiac Chest Pain
This is a prospective randomised clinical trial performed in a single center at Hospital Universiti Sains Malaysia (USM), Kelantan, Malaysia.
- Trial name
- NCT03319121
- Testing
- Empirical therapy group, Guided therapy group
- Where
- Malaysia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Pregnancy Related, Heart Rate Variation (HRV)
Cardiovascular Research in EMbarazo and MAternity (EMMA). Study on Heart Rate Variability and Hemodynamic Adaptations During Pregnancy and Postpartum.
Heart rate variability (HRV) provides a non-invasive assessment of autonomic control of the nervous system over the heart. During pregnancy, the cardiovascular system adapts significantly, affecting HRV and hemodynamics.
- Conditions
- Pregnancy Related, Heart Rate Variation (HRV), Hemodynamics
- Trial name
- EMMA (NCT07376616)
- Testing
- Assessment of HRV and blood pressure
- Where
- Spain
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Virtual Reality, Fear
Effect of Virtual Reality Glasses Application on Surgical Fear and Anxiety
Purpose and Type of Research:This study will be conducted to examine the effect of virtual reality glasses on surgical fear and anxiety in patients scheduled for cardiovascular surgery.
- Conditions
- Virtual Reality, Fear, Anxiety State, Surgery
- Trial name
- NCT06127758
- Testing
- virtual reality glasses application, classical training
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Mental Illness Persistent, Cardiovascular Prevention
Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness
The goal of this prospective, randomized trial is to explore the link between cardiovascular disease and mortality in individuals with severe and persistent mental illness (SPMI).
- Trial name
- NCT05659498
- Testing
- Cardiac Rehabilitation Program
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Phospholamban R14del Cardiomyopathy, Heart Failure
Identification of Disease Specific Pathways and Modifiers in Phospholamban R14del Cardiomyopathy
Background A specific mutation in phospholamban (the PLN R14del mutation), has its origin in the northern parts of the Netherlands (Figure) and causes a severe lethal dilated and/or an arrhythmogenic cardiomyopathy.
- Conditions
- Phospholamban R14del Cardiomyopathy, Heart Failure, Cardiomyopathy, Familial
- Trial name
- DECIPHER-PLN (NCT04978987)
- Where
- Netherlands
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Heart Murmurs
Wireless Handheld 8-lead ECG Device Performance in Heart Patients (Rapid Rhythm)
This study is designed to compare the performance of both 6 and 10 electrode ECGs from the handheld device with the conventional 12 lead ECG.
- Trial name
- NCT03501836
- Testing
- Rapid Rhythm Handheld 8-lead ECG Device
- Where
- United Kingdom
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
High-intensity Interval Exercise, Heart Rate
Acute Physiological and Perceptual Responses to Novel Forms of High-intensity Interval Exercise
Randomised cross-over study seeking to explore the acute physiological and perceptual responses to three novel forms of high-intensity interval training (HIT).
- Conditions
- High-intensity Interval Exercise, Heart Rate, Rating of Perceived Exertion, Blood Pressure
- Trial name
- NCT03359928
- Testing
- Boxing, Stair stepping, Stair climbing
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Teesside University
Cardiac Arrest
Videolaryngoscopy During Child Intubation
We hypothesized that the video-laryngoscopes are beneficial for intubation of pediatric manikins while performing CPR. In the current study, we compared effectiveness of three video-laryngoscopes and Macintosh (MAC) laryngoscopes…
- Trial name
- NCT02289664
- Testing
- MAC, Coopdech, CoPilot
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Neonatal Congenital Heart Disease
Optimization of Two-Indicator Screening Protocol for Neonatal Congenital Heart Disease at High Altitude
This is a prospective observational screening study. First, researchers will optimize a two-indicator screening protocol for neonatal congenital heart disease (NCHD) adapted to high-altitude regions and evaluate its screening…
- Trial name
- NCT07901998
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Vascular Function, Atherothrombosis
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work.
- Trial name
- FIRECOP (NCT01813032)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Connective Tissue Diseases, Right Ventricular Hypertrophy
Early Detection of Cardiac Impairment and Prediction of RV Hypertrophy in Patients With CTD
There have been reports suggesting that progressive RV failure and death in connective tissue disease (CTD) are related to right ventricular hypertrophy (RVH) and dilation, irrespective of pulmonary arterial hypertension (PAH).
- Trial name
- EARLY-MYO-CTD (NCT04297371)
- Testing
- CMR examination
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Atrial Fibrillation
Blinded Randomized Controlled Trial of Artificial Intelligence Guided Detection of Intracardiac Thrombus
To determine whether an integrated AI decision support can save time and improve the accuracy of detection of intracardiac thrombus, the investigators are conducting a blinded, randomized controlled study of AI-guided detection…
- Trial name
- NCT06206187
- Testing
- Automated detection of the intracardiac thrombus through deep learning, Electrophysiologist judgment of the intracardiac thrombus
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
High Blood Pressure
Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation
Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic…
- Trial name
- NCT00204984
- Testing
- oral hydralazine and intravenous nesiritide
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Hypertrophic Cardiomyopathy
Study Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects
Mavacamten is a small-molecule allosteric inhibitor of cardiac myosin that reversibly inhibits its binding to cardiac actin, thereby relieving systolic hypercontractility and improving ventricular compliance.
- Trial name
- NCT05135871
- Testing
- Mavacamten
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- LianBio LLC
Arrhythmias
Acute Mechanical Response to Anti-arrhythmic Drug Therapy
The aim of this study is to determine if anti-arrhythmic drugs with a sodium channel-blocking mechanism exert a detrimental electromechanical effect on cardiac function in patients depending upon baseline intraventricular…
- Trial name
- AAD and CRT (NCT02575534)
- Testing
- Procainamide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Evan Adelstein, MD
Healthy Volunteer
coMparison Between invAsive and Non-invasive assessmenT on Blood Pressure and Cardiac Function in HealthY Participants
This is a cross-sectional cohort study which aims to compare the invasive and non-invasive assessments on aortic blood pressure and cardiac funtion in subjects without history of cardio-vascular disease.
- Trial name
- MATCHY (NCT03372616)
- Testing
- Invasive left ventricular diastolic function assessment, Invasive aortic blood pressure measurement, Non-Invasive left ventricular diastolic function assessment
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
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