Clinical trials: Cardiac Abnormalities
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high…
- Conditions
- Bicuspid Aortic Valve, Thoracic Aortic Aneurysm, Aortic Dissection
- Trial name
- AoRTAS (NCT04083118)
- Testing
- clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Migraine Headache, PFO - Patent Foramen Ovale
Migraine With Aura and Patent Foramen Ovale: Identification of Biomarkers to Select Patients In Whom Intervention Would Be Beneficial (MANET)
This is a multicenter prospective observational study aimed to asses whether a specific prothrombotic platelet phenotype can discern migraine patients with PFO (patent forame ovale) - related symptoms from patients with…
- Trial name
- MANET (NCT06046508)
- Testing
- blood samples collection
- Where
- 3 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Congenital Heart Defects, Down Syndrome
Investigation of Cardiopulmonary Parameters, Motor Development and Muscle Strength in DS With and Without CHD
Congenital heart diseases (CHD) are detected in 40-60% of individuals with Down syndrome (DS) and increase the risk of developmental delay in the presence of syndromes.
- Conditions
- Congenital Heart Defects, Down Syndrome, Gross Motor Development Delay
- Trial name
- NCT05191654
- Testing
- evaluation of cardiopulmonary parameters, gross motor development and hand grip strength
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Atılım University
Endothelial Dysfunction, Myocardial Perfusion Abnormalities
Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction
The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion deficits and/or abnormalities…
- Conditions
- Endothelial Dysfunction, Myocardial Perfusion Abnormalities, Cardiac MRI Perfusion With Vasomotor Stress, Diabetes
- Trial name
- NCT00808535
- Testing
- Cardiac Perfusion MRI w Vasomotor Stress
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Trisomy 21, Trisomy 18
Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood
The purpose of this study is to collect maternal blood samples from pregnant women carrying a fetus with a confirmed diagnosis of chromosomal abnormality or genetic disorder including microdeletions in order to further develop a…
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13, Sex Chromosome Abnormalities
- Trial name
- MAPS (NCT01852708)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Congenital Heart Disease With Systemic Right Ventricle
Study of Adaptation of the Right Ventricle to Systemic Afterload
the first purpose of the study is to determine the adaptative mechanisms of right ventricle (RV) to systemic afterload, and the mechanisms of RV failure, in patients with congenital heart disease and subaortic RV, using cardiac…
- Trial name
- STARS (NCT02066506)
- Testing
- asymptomatic group, symptomatic group
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Congenital Heart Disease, Cardiovascular Disease
Technical Development for Pediatric Cardiovascular MRI
This study will explore new ways of using magnetic resonance imaging (MRI) to evaluate pediatric patients with cardiovascular disease,congenital heart disease in patients of all ages, fetuses undergoing clinically indicated MR…
- Trial name
- NCT02892136
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
22q.11.2 Deletion/Duplication
Non-Invasive Chromosomal Evaluation of 22q11.2
This study is being conducted to develop and evaluate a cell-free fetal DNA test (Harmony) for non-invasive prenatal detection of 22q11.2 chromosomal deletion or duplication.
- Trial name
- 22Q (NCT02541058)
- Where
- Belgium
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Cindy Cisneros
Bundle-Branch Block, Heart Septal Defects, Ventricular
Right Bundle Branch Block After Surgical Closure of Ventricular Septal Defect
The most common congenital heart disease is the ventricular septal defect, and after surgical closure of a such defect, an arrythmia called the right bundle branch block, is very frequent.
- Trial name
- NCT01480908
- Testing
- Echocardiography at rest, Echocardiography during exercise, MRI at rest
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hematologic Diseases
Hematological Abnormalities in Children
the aim of the study is to determine Hematological abnormalities in Congenital Cyanotic Heart Disease
- Trial name
- NCT05541835
- Testing
- sampling
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
D-Transposition of Great Arteries, Tetralogy of Fallot
Myocardial Contrast Echocardiography in Congenital Heart Disease
Patients with congenital heart disease in whom the right ventricle is exposed to pressure or volume overload show progressive systolic dysfunction of the right ventricle, the fact of which conveys substantial morbidity and…
- Trial name
- NCT00412685
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Duchenne Muscular Dystrophy
Heart Rate Variability in Individuals With Duchenne Muscular Dystrophy
A cross-sectional study was carried out, in which 40 boys, aged 11 to 18 years, were evaluated. The recruitment of groups was carried out at the neuromuscular disease outpatient clinic of the Federal University of São Paulo…
- Trial name
- NCT04740554
- Testing
- Duchenne Muscular Dystrophy group with Deflazacort, Duchenne Muscular Dystrophy group with Prednisone/Predisolone, Duchenne Muscular Dystrophy group without Corticosteroids therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypoplastic Left Heart Syndrome
Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes
We believe that how a baby with Hypoplastic Left Heart Syndrome (HLHS)does after a major open heart operation, measured by things like blood pressure, oxygen saturation, heart rate and others, may have an impact on development.
- Trial name
- NIRS-ND (NCT00464100)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.
- Conditions
- Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1, Catecholaminergic Polymorphic Ventricular Tachycardia Type 2
- Trial name
- ACTIVELY (NCT06661278)
- Testing
- Exercise tolerance test, Physical activity & heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Hypertension, Heart Failure
Frailty in Children With Cardiac Disease
Frailty is a complex biologic syndrome of diminished physiologic reserve that leads to decreased resistance to stressors and is associated with adverse health outcomes.
- Conditions
- Pulmonary Hypertension, Heart Failure, Single Ventricle
- Trial name
- NCT02999438
- Testing
- Actigraph to check activity levels at home
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Down Syndrome, Autonomic Dysfunction
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with widespread organ dysfunction, including abnormalities in the autonomic nervous system (ANS).
- Trial name
- DIVE (NCT07238465)
- Testing
- Cold Stress, Maximal Dynamic Exercise, Isometric Handgrip Exercise with Post-Exercise Muscle Ischemia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver