Clinical trials: Cardiac Abnormalities
Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome
Quantification of Elastin Markers Synthesis in Williams-Beuren Syndrome and 7q11.23 Micro-duplication Syndrome
Introduction: Williams-Beuren syndrome is a rare genetic disorder caused by a 7q11.23 microdeletion. The phenotype associates vasculopathy (arterial stenosis, hypertension), dimorphism and intellectual disability.
- Conditions
- Williams-Beuren Syndrome, Micro-duplication 7q11.23 Syndrome, Vasculopathy
- Trial name
- ELAST7 (NCT04051086)
- Testing
- Physical examination and Urine and blood samples, Urine and blood samples
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cardiac Disease, Pediatric Disease
Parametric Mapping in Paediatric Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is increasingly an important tool for diagnosis and management of cardiac diseases in children.
- Conditions
- Cardiac Disease, Pediatric Disease, Cardiomyopathies, Congenital Disorders
- Trial name
- NCT04068987
- Testing
- MRI parametric mapping
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hong Kong Children's Hospital
Turner Syndrome
Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy
Several studies have demonstrated that Turner Syndrome patients have elevated liver enzymes readily suppressible by a short course of HRT.
- Trial name
- NCT00825617
- Testing
- Hormone replacement therapy
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ventricular Septal Defect
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.
The overall objective for this study is to test whether β2-agonists will affect the cardiopulmonary capacity of VSD-operated patients compared with un-operated VSD-patients and healthy age- and gender-matched controls.
- Trial name
- NCT02914652
- Testing
- Salbutamol
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Long QT Syndrome
Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
Torsades de pointes (TdP) is a potentially fatal ventricular arrhythmia associated with corrected QT (QTc) interval prolongation.
- Trial name
- NCT02513940
- Testing
- Testosterone, Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Indiana University
Long QT Syndrome
Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function
The primary objective of this study is to evaluate the pharmacokinetic (PK) profile of oral eleclazine and its metabolite, GS-623134, in participants with normal and impaired hepatic function.
- Trial name
- NCT02412098
- Testing
- Eleclazine
- Where
- 7 sites in United States, Germany and 2 more
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Heart Defects, Congenital, Tetralogy of Fallot
Physical Capacity and Activity in Children With Congenital Heart Disease
Congenital malformations correspond to defects in organ morphogenesis identifiable at birth or intrauterine life, affecting 2-3% of births.
- Trial name
- NCT03275844
- Testing
- Physical activity assessment
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rodrigo Torres
Coronary Artery Disease, Myocarditis
A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
This study aims to identify and assess new CMR techniques that can improve current CMR protocols.
- Conditions
- Coronary Artery Disease, Myocarditis, Infiltrative Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- NCT04464655
- Where
- Canada
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Dilated Cardiomyopathy
The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy
Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM). Its presence is believed to increase the risk of malignant ventricular arrhythmias (VA), but the mechanism of…
- Trial name
- DCM-MSF (NCT05026112)
- Testing
- ECG-Imaging, Cardiac MRI scan
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Marfan Syndrome, Marfan Related Disorders
Development of a Blood Test for Marfan Syndrome
The objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in Marfan syndrome and Marfan-related disorders.
- Conditions
- Marfan Syndrome, Marfan Related Disorders, Control Subjects
- Trial name
- NCT02148900
- Where
- 5 sites in United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myocardial Deformation, Coronary Artery Anomaly
Correlation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardiomyopathy
Correlation between Myocardial Deformation and Coronary Tortuosity and Analysis of Genetic Factors Among Hypertrophic Cardiomyopathy Patients
- Conditions
- Myocardial Deformation, Coronary Artery Anomaly, Hypertrophic Cardiomyopathy, Genetic Mutation
- Trial name
- NCT04830787
- Testing
- no intervention
- Where
- China
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Dilated Cardiomyopathy
Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study
The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study.
- Trial name
- NCT04638621
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis
A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384
The primary objectives of the study are to evaluate the safety, tolerability and pharmacokinetics of A4250 after single or multiple oral doses in healthy subjects.
- Conditions
- Orphan Cholestatic Liver Diseases, Primary Biliary Cirrhosis, Progressive Familial Intrahepatic Cholestasis, Alagille Syndrome
- Trial name
- NCT02963077
- Testing
- A4250, CRC (A3384), Questran
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Albireo
Other Diseases or Conditions
Mother-caregivers of Children With Duchenne Muscular Dystrophy
The incidence of Duchenne Muscular Dystrophy (DMD) is approximately 1 in 3.500 male newborns. During its progression there is loss of mobility, swallowing difficulties and a significant reduction in respiratory capacity.
- Trial name
- DMDK (NCT01921374)
- Testing
- sleep parameters, Hormonal profile, Inflammatory profile
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Monica Levy Andersen
Heart Defects, Congenital, Critical Illness
Leuven Growing Into Deficit Follow-up Study
The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old…
- Conditions
- Heart Defects, Congenital, Critical Illness, Mental Processes, Child
- Trial name
- Leuven-GID (NCT01632813)
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Ischemia, Peripheral Arterial Disease (PTA
The ABSORB Bioresorbable Scaffold Below the Knee (BTK) Study
ABSORB BTK Study: A prospective, multicenter, controlled clinical evaluation of the use of a bioresorbable drug eluting stent in the arterial vasculature below the knee
- Conditions
- Ischemia, Peripheral Arterial Disease (PTA, Arterial Occlusive Diseases
- Trial name
- NCT02793349
- Testing
- Absorb Bioresorbable Vascular Scaffold
- Where
- 4 sites in Australia, Netherlands and 1 more
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales