Clinical trials: Cardiac Anomaly
Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
- Trial name
- NCT06523582
- Where
- 3 sites in Mexico
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Primary Ciliary Dyskinesia, Kartagener Syndrome
Genetics of Primary Ciliary Dyskinesia
This study is designed to study DNA sequencings for mutations in a research genetic test panel of genes (which contains all 32 known and/or published genes associated with PCD).
- Trial name
- NCT02389049
- Where
- 8 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- University of North Carolina, Chapel Hill
CT Coronary Angiography, Arterial Switch Operation
CT Coronary Angiography After Arterial Switch Operation
The purpose of this study is to find a non-invasive alternative (with using ECG gated 64-slice CT angiography) to invasive coronary angiography for detecting coronary lesions in patients who had undergone arterial switch…
- Trial name
- SCANTGV (NCT01153776)
- Testing
- 64-slice CT angiography
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fetal Growth Retardation
Day to Day Variation in Fetal Heart Rate Variability
This study evaluates the day-to-day variation in fetal heart rate variability based on non-invasive fetal-ECG (NI-FECG). Furthermore, the effect of fetal movements on fetal heart rate variability will be assessed.
- Trial name
- (FHRV) (NCT04289350)
- Testing
- fetal heart rate variability
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- University of Aarhus
Cardiology
Bivalirudin as a Procedural Anticoagulant in Pediatrics
Pharmacokinetics and safety of weight based bivalirudin in children
- Trial name
- NCT00503126
- Testing
- bivalirudin
- Volunteers
- 110 people
- Sponsor
- The Medicines Company
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high…
- Conditions
- Bicuspid Aortic Valve, Thoracic Aortic Aneurysm, Aortic Dissection
- Trial name
- AoRTAS (NCT04083118)
- Testing
- clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
D-Transposition of Great Arteries, Tetralogy of Fallot
Myocardial Contrast Echocardiography in Congenital Heart Disease
Patients with congenital heart disease in whom the right ventricle is exposed to pressure or volume overload show progressive systolic dysfunction of the right ventricle, the fact of which conveys substantial morbidity and…
- Trial name
- NCT00412685
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Valve Diseases
Methods Study to Evaluate Use of Cardiac Ultrasound to Assess Heart Valve Abnormality in People.
Methods study to evaluate use of cardiac ultrasound to assess heart valve abnormality in people.
- Trial name
- NCT00359489
- Testing
- cardiac echosonography
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer
Enterocolitis, Necrotizing, Congenital Heart Disease
Utility of Bowel Ultrasound in Diagnosing Necrotizing Eneterocolitis in Congenital Heart Disease
To evaluate the feasibility of performing a randomized pilot control trial of two diagnostic screening strategies for necrotizing enterocolitis in patients with congenital heart disease.
- Trial name
- NCT03142685
- Testing
- Bowel Ultrasound
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Hypoplastic Left Heart Syndrome
Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
This is a Phase I study to determine the safety and feasibility of injections of autologous umbilical cord blood (UCB) cells into the right ventricle of Hypoplastic Left Heart Syndrome (HLHS) children undergoing a scheduled Glenn…
- Trial name
- NCT01883076
- Testing
- autologous cell-based delivery
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Timothy J Nelson, MD, PhD
Dilated Cardiomyopathy, Heart Failure
Assessment of Right Ventricular Function in Advanced Heart Failure
We examined the feasibility and reliability of a combined echocardiographic and right heart catheterization (RHC) approach for right ventriculo/arterial (R-V/A) coupling assessment in HF patients with dilated cardiomyopathy…
- Trial name
- NCT03893760
- Testing
- Ventriculo-arterial coupling assessment (R-V/A)
- Where
- 2 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Orthodontic Extraction
Comparison of Rate and Amount of Orthodontic Space Closure
The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is…
- Trial name
- Premolar (NCT07445321)
- Testing
- Space Closure
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Coronary Artery Disease, Proteus Syndrome
Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants
Since 2007, the cost of sequencing a diploid human genome has fallen dramatically, from approximately $70 million to $20,000. As affordable sequencing platforms become more widely available, the advancement of biomedical science…
- Conditions
- Coronary Artery Disease, Proteus Syndrome, Coffin - Sins Syndrome, Familial Isolated Hyperparathyroidism
- Trial name
- NCT01369953
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Dilated Cardiomyopathy
A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) causes significant morbidity and mortality and is the third most common cause of heart failure and the most frequent reason for heart transplantation.
- Trial name
- NCT02915718
- Testing
- protein A immunoadsorption
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Congenital Heart Disease
Northwest Adult Congenital Heart Disease Observatory
The incidence of congenital heart disease is about 8 per thousand live births. Thanks to advances in cardiac surgery, 90% of children born with heart defects reach adolescence and adulthood.
- Trial name
- CARL (NCT02897323)
- Testing
- description
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Caen
Congenital Heart Disease
Phase I Safety and Feasibility Study of Intracoronary Delivery of Autologous Bone Marrow Derived Mononuclear Cells
The objective of this study is to determine the safety and feasibility of autologous mononuclear cells (MNC) collected from bone marrow (BM) and intracoronary delivery for individuals with declining performance of their single…
- Trial name
- NCT02549625
- Testing
- Autologous Bone Marrow-derived Mononuclear Cells
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Timothy J Nelson, MD, PhD
Ischemic Stroke, Patent Foramen Ovale
Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence
A patent foramen ovale (PFO) is found more frequently in patients with an ischemic stroke than in control subjects. Therapeutic options to prevent stroke recurrence include antiplatelet drugs, oral anticoagulants, and…
- Conditions
- Ischemic Stroke, Patent Foramen Ovale, Atrial Septal Aneurysm, Migraine
- Trial name
- CLOSE (NCT00562289)
- Testing
- aspirin, Antivitamins K or rivaroxaban or dabigatran or apixaban, Devices for PFO closure
- Where
- France
- Volunteers
- 664 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Heart Disease
NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery
Neonates and infants that have cardiac surgery with cardiopulmonary bypass (CPB) for congenital heart disease are at great risk for experiencing life-threatening low cardiac output syndrome (LCOS) in the first 24 hours after…
- Trial name
- NCT01849120
- Testing
- EQUANOX Advance 8004CB sensor
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Usability and Tolerability of the Norditropin NordiFlex® Injection Device in Children Never Previously Treated With Growth Hormone
This study is conducted in Europe. The purpose of this study is to assess the impact on daily life for children new to using a growth hormone injection device.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Genetic Disorder, Turner Syndrome
- Trial name
- NCT01327924
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Novo Nordisk A/S