Clinical trials: Cardiac Arrhythmia, open to volunteers
Atrial Fibrillation (AF), Cardiomyopathy, Secondary
Patient Selection and Long-Term Outcomes of Pace & Ablate Strategy in Atrial Fibrillation
Atrioventricular node ablation with permanent pacing (the "pace-and-ablate" strategy) controls ventricular rate in atrial fibrillation that has not responded to drug therapy or catheter ablation.
- Conditions
- Atrial Fibrillation (AF), Cardiomyopathy, Secondary, Pacing-Induced Cardiomyopathy, Heart Failure
- Trial name
- REPACE (NCT07852221)
- Where
- 5 sites in Poland, Switzerland and 1 more
- Volunteers
- 2,600 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ventricular Arrhythmia, Cardiomyopathies
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
EP-SCOPE is a prospective, multicentric, non-randomized pilot study that aims to estimate the risk of life-threatening ventricular arrhythmia through use of advanced electrophysiological studies in patients with ischemic or…
- Conditions
- Ventricular Arrhythmia, Cardiomyopathies, Left Ventricular Ejection Fraction Less Then or Equal to 50percent
- Trial name
- EP-SCOPE (NCT07020702)
- Testing
- Implantation of an ICD
- Where
- 3 sites in France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Bordeaux
Left Bundle-Branch Block, Aortic Valve Stenosis
Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI
The primary hypothesis of the proposed study is that an electrophysiology-based algorithmic approach is superior to standard clinical follow-up with 30-day monitoring in reducing the combined endpoint of syncope, hospitalization…
- Trial name
- COME-TAVI (NCT03303612)
- Testing
- Pacemaker implant, Transcutaneous cardiac monitor
- Where
- 10 sites in Canada, France
- Volunteers
- 250 people
- Sponsor
- Montreal Heart Institute
Ventricular Tachycardia
Catheter Ablation of Haemodynamically Not-tolerated Electrical Storm in Structural Heart Disease
This is a multi-center, parallel-group, randomized, open-label trial evaluating the clinical outcome and efficacy of emergency catheter ablation versus conventional stepped-care strategies in patients with haemodynamically…
- Trial name
- NCT06455020
- Testing
- Catheter ablation, Stepped-care strategies
- Where
- 4 sites in China
- Volunteers
- 96 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Persistent
Subxyphoid Hybrid MAZE Registry for Patients With Persistent Atrial Fibrillation
Minimally invasive surgical procedures have been advocated as an alternative to catheter ablation for the treatment of persistent atrial fibrillation.
- Trial name
- SubXMAZE (NCT04148625)
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Aortic Stenosis, Right Bundle-Branch Block
Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation
The goal of this clinical trial is to learn about the safety and outcome of prophylactic pacemaker implantation in patients with right bundle-branch block undergoing trans-catheter aortic valve (TAVI) implantation in patients…
- Trial name
- TAVI-PACE (NCT05889208)
- Testing
- Prophylactic pacemaker implantation
- Volunteers
- 320 people
- Sponsor
- Aalborg University Hospital
Atrial Fibrillation, Postoperative Complications
Atrial Dyssynchrony to Predict Arrhythmias in the Postoperative Setting of Cardiovascular Surgery.
This study aims to improve the prediction for developing arrhythmias in the postoperative period of cardiovascular surgery by using non-invasive echocardiographic techniques that are sensitive to detect inter and intra-atrial…
- Trial name
- SAD-POAF (NCT07388108)
- Testing
- Atrial dyssynchrony
- Where
- Argentina
- Volunteers
- 138 people
- Sponsor
- School of Medicine. National University of Cuyo
Arrhythmia
Arrhythmia Cohort Study
The goal of this prospective, observational registry study is to evaluate the long-term effectiveness, safety, and impact of different kinds of treatment on the quality of life across diverse arrhythmia subtypes and patient…
- Trial name
- NCT07123896
- Testing
- Normal treatment with catheter ablation or medicine, Drug Treatment
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Abnormal Heart Rhythms
COMparison of Physiological Algorithms for Real-time Evaluation of Atrial Fibrillation
This is a cohort study to evaluate algorithms for mapping atrial fibrillation by mapping atrial structure and mapping electrical activity to detect physiologically important areas.
- Trial name
- COMPARE_AF (NCT02997254)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Stanford University
Atrial Fibrillation (AF)
Electronic Blood Pressure Monitor for Atrial Fibrillation Detection
Study name: Study on the Effectiveness of Atrial Fibrillation Screening Using Electronic Blood Pressure Monitor with Atrial Fibrillation Detection Function Objective: This study compares an electronic blood pressure monitor…
- Trial name
- NCT06931288
- Testing
- Blood pressure monitor, Single-lead ECG
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Electrolyte Disorder, Arrhythmia
Validation of the Accuracy of a Novel POCT Dry Electrolyte Analysis System in the Acute Care Setting
The goal of this study is to compare the performance of a novel Point-of-Care Testing (POCT) dry electrolyte analyzer (P1) with the Nova Stat Profile pHOx Ultra Analyzer System (Nova) in an acute care setting.
- Conditions
- Electrolyte Disorder, Arrhythmia, Stroke
- Trial name
- NCT06726460
- Testing
- Nova Stat Profile pHOx Ultra Analyzer System(Nova), Novel POCT dry electrolyte analysis system(P1)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhujiang Hospital
Atrial Fibrillation, Post-cardiac Surgery
Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients
Post-operative atrial fibrillation is a common problem post cardiac surgery with rates exceeding 30%. Atrial fibrillation has multiple adverse effects on cardiac hemodynamics and can lead to hypotension, diminished end organ…
- Trial name
- NCT04748991
- Testing
- Vernakalant, Amiodarone
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Fibrillation, Atrial
Thromboembolic And Bleeding Risks During anticoaGulant trEatment in Asian paTients With Atrial Fibrillation (TARGET-AF)
This study was design to investigate the efficacy and safety of NOAC therapy in Koreans
- Trial name
- NOAC (NCT06874894)
- Where
- 2 sites in South Korea
- Volunteers
- 1,021 people
- Sponsor
- Chung-Ang University Hospital
Sickle Cell Disease
Early Screening and Treatment of Heart Complication in Sickle Cell Disease
This study tests whether early heart screening and treatment for iron overload in subjects with sickle cell disease can prevent heart problems and reduce hospitalizations.
- Trial name
- NCT07023666
- Testing
- Deferoxamine, Deferasirox, Deferiprone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Inova Health Care Services
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Atrial Fibrillation (AF)
Discontinuation of Anticoagulation With Intensive Rhythm Monitoring in Post-ablation Patients With Atrial Fibrillation
DIAMOND-AF is a multicenter, randomized, open-label trial evaluating whether discontinuing oral anticoagulation after successful atrial fibrillation ablation can reduce bleeding risk without increasing death or thromboembolism…
- Trial name
- DIAMOND-AF (NCT06871228)
- Testing
- NOAC discontinuation, NOAC continuation, Smartwatch single-lead ECG monitoring
- Where
- 22 sites in China
- Volunteers
- 4,100 people
- Sponsor
- Beijing Anzhen Hospital
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation
The NEXT PULSE study is a pre-market, prospective, multi-center, non-randomized, interventional clinical study. Adult subjects with symptomatic paroxysmal or persistent AF who provided consent will be enrolled and treated with…
- Trial name
- NEXT PULSE (NCT07575828)
- Testing
- PulseSelect Pulse Field Ablation (PFA) System
- Volunteers
- 320 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Post Operative Pain, Bradycardia
Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery
To compare the immediate and postoperative analgesic efficacy of S-FICB and PENG block will be the objective. The use of ultrasonography in anesthesia has helped the anesthetist to see the nerve, needle and the distribution of…
- Conditions
- Post Operative Pain, Bradycardia, Hypotension, Femur Fracture
- Trial name
- NCT06568770
- Testing
- USG GUIDED SUPRA-INGUINAL FASCIA ILIACA BLOCK, PERICAPSULAR NERVE BLOCK
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Sahiwal medical college sahiwal
Ventricular Tachycardia (VT), Catheter Ablation
Using Non-Invasive Mapping To Eliminate Structural Heart Disease Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal and dangerous heart rhythm affecting the lower chambers of the heart (the ventricles).
- Trial name
- UNITE-VT (NCT07759427)
- Testing
- VIVO-assisted mapping
- Where
- 3 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Warwick
Ventricular Arrhythmia, Ventricular Tachycardia (V-Tach)
Proton Radiosurgery for the Treatment of Malignant Ventricular Tachyarrhythmias
Ventricular arrhythmias (VAs) are the leading cause of sudden cardiac death (SCD) worldwide. The implantable defibrillator (ICD) increases survival in patients at risk of VA, with data of superiority to antiarrhythmic drugs.
- Trial name
- TOVEL (NCT06769451)
- Testing
- Stereotactic Arrhythmia Radioablation (STAR) with Proton Therapy
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
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