Clinical trials: Cardiac Bypass Patients
Cardiac Surgery, Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery Study
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- Bic-MC (NCT00672334)
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Austin Health
Microcirculation, Anesthetic Complication Spinal
Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass.
- Trial name
- NCT03209193
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Bypass Graft Triple Vessel, Blood Coagulation Disorders
Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery
Aim of this study is to investigate whether patients preoperatively treated with acetylsalicylic acid and/or clopidogrel have fewer perioperative bleeding and lower amounts of blood substitution when managed by ROTEM (whole blood…
- Trial name
- NCT00516126
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Pain.
The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting
We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence…
- Trial name
- NCT00623285
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Coronary Artery Disease
PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG
Multi-centre, randomised clinical trial with anticipated 17 European centres: in the Netherlands, Belgium, Germany and UK. Patients with a dysfunctional bypass graft with a clinical indication for revascularization will be…
- Trial name
- PROCTOR (NCT03805048)
- Testing
- Percutaneous coronary intervention
- Where
- 21 sites in Belgium, Germany and 3 more
- Volunteers
- 221 people
- Sponsor
- Amsterdam UMC, location VUmc
Rheumatic Heart Disease, Cardiopulmonary Bypass
Thymosin α1 Use in Rheumatic Heart Disease Patients Undergoing Cardiac Surgery on Cardiopulmonary Bypass
Rheumatic heart disease usually accompanied by weakened immune function. And the cardiopulmonary bypass further aggravating the decline of immune function.
- Conditions
- Rheumatic Heart Disease, Cardiopulmonary Bypass, Immunotherapy
- Trial name
- NCT05487469
- Testing
- Thymosin Alpha1, Blank Control
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Anemia
Effect of Arterial Oxygen Partial Pressure on Mixed Venous Oxygen Saturation
Mixed venous oxygen saturation is known to reflect oxygen delivery and, thus, is frequently monitored in patients undergoing cardiac surgery.
- Trial name
- NCT04144205
- Testing
- Change of the fraction of inspired oxygen
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Frail Elderly, Coronary Artery Disease
Off-pump Versus On-pump Coronary Artery Bypass Grafting in Frail Patients
Frailty is defined as a geriatric syndrome of impaired resiliency to stressors (such as cardiac surgery) that has been delineated recently in the cardiovascular literature.
- Trial name
- FRAGILE (NCT02338947)
- Testing
- Off-pump coronary-artery bypass grafting, On-pump coronary-artery bypass grafting
- Where
- 7 sites in United States, Brazil
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Circulatory Failure, Cardiac Arrest
Evaluation of Efficacy of the Prototype RPC (Rapid Pulse Confirmation) Device in Detecting Return of Pulsatile Flow in Patients Preparing to Separate From CPB (Cardiopulmonary Bypass)
Effective chest compressions are essential to survival in an arrest patient receiving CPR (cardiopulmonary resuscitation). A challenge in providing effective chest compressions is frequent interruption of compressions.
- Trial name
- NCT04526249
- Testing
- rapid pulse confirmation device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Michael Kyle Ritchie
Coronary Artery Bypass Grafting, Postoperative Pain
Preoperative Pain Neuroscience Education in Patients Undergoing CABG
This randomized controlled trial evaluated the effects of a single preoperative pain neuroscience education (PNE) session on postoperative pain-related outcomes in patients undergoing elective coronary artery bypass grafting…
- Trial name
- PNE-CABG (NCT07783750)
- Testing
- Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- İsmail Palalı
Sublingual Microcirculation
Effect Of Dexmedetomidine On Sublingual Microcirculation In Patients Undergoing On Pump CABG Surgery
This study is designed to explore the possible effects of dexmedetomidine infusion on sublingual microcirculation in patients undergoing on-pump coronary artery bypass graft surgery
- Trial name
- NCT02714725
- Testing
- Dexmedetomidine, Propofol infusion
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Coronary Artery Disease, Cardiac Valve Insufficiency
Study on the Clinical Performance of Steelex® Sternum Set for Sternal Closure
The study is designed as a retrospective, international, multi-center cohort study to evaluate Steelex® Sternum Set for sternum closure.
- Conditions
- Coronary Artery Disease, Cardiac Valve Insufficiency, Aortic Valve Stenosis
- Trial name
- STERCCAS (NCT05439395)
- Testing
- Sternum Closure after Cardiac Surgery
- Where
- 2 sites in Germany, Spain
- Volunteers
- 229 people
- Sponsor
- Aesculap AG
Atrial Fibrillation, Heart Failure
Cardiopulmonary Bypass and Ventricular Remodeling
The goal of this observational study is determine if reduced ventricular ejection fraction is a factor that determines a pro-oxidant imbalance in patients subjected to cardiac surgery with cardiopulmonary bypass.
- Trial name
- CBP-VR (NCT06256965)
- Testing
- Detection of peri-operative atrial fibrillation
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- University of Chile
Cardiac Surgery, Cardiopulmonary Bypass
Pentastarch Use in Cardiac Surgery
Patients undergoing cardiac surgery with cardiopulmonary bypass require significant fluid administration. Fluids are used routinely to replace blood lost during and after surgery.
- Trial name
- NCT00182377
- Testing
- Pentastarch (displace either 500 ml or 1000 ml of pump prime with pentastarch)
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Vasodilation
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
Objective: To observe the effects of exercise training on vascular endothelial function in patients undergoing coronary artery bypass graft (CABG) alone in phase III after six months of Cardiac rehabilitation programs (CRP).
- Trial name
- NCT02265107
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Universidade Federal do Rio Grande (FURG)
Aortocoronary Bypass
Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion
Linear flow during cardiopulmonary bypass (CPB) frequently induces renal damage. We will evaluate whether automatic intra-aortic balloon pump (IABP) induce pulsatile perfusion preserves renal function in patients undergoing…
- Trial name
- NCT00454428
- Testing
- pulsatile intra-aortic balloon pump
- Where
- Italy
- Sponsor
- University of Catanzaro
Xenon, Sevoflurane
A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon
The aim of this study is to determine whether xenon - as compared to sevoflurane - can be applied safely in patients for general anesthesia before and after CABG implantation.
- Conditions
- Xenon, Sevoflurane, Anesthetics, Inhalation, Coronary Disease
- Trial name
- CArDiAX (NCT01285271)
- Testing
- Xenon, Sevoflurane
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Cardiovascular Disease, Ischemic Heart Disease
Can Dipyridamole Induce Protection Against Ischemia and Reperfusion Injury in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG)?
Rationale: Due to western lifestyle human coronary arteries are prone to develop atherosclerotic plaques. Hence the heart is an important target organ for atherothrombotic complications: myocardial ischemia, arrhythmias…
- Trial name
- NCT01295567
- Testing
- Dipyridamole
- Where
- Netherlands
- Volunteers
- 95 people
- Sponsor
- Radboud University Medical Center
Cardiac Surgery
Efficacy and Safety of Sodium Heparin in Patients (Cristália)
The objective of this study is to verify, through a randomized, single-blind, multicentre, parallel and comparative study, the effectiveness of heparin sodium of porcine origin in patients undergoing heart surgery at that require…
- Trial name
- NCT00894998
- Testing
- heparin sodium - Cristália, Heparin sodium APP
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Azidus Brasil
Heart Failure
AZD8601 Study in CABG Patients
This is a randomized, double-blind, placebo-controlled, sequential design, multicentre study in patients with moderately impaired systolic function undergoing CABG surgery.
- Trial name
- NCT03370887
- Testing
- AZD8601
- Where
- 10 sites in United States, Finland and 3 more
- Volunteers
- 11 people
- Sponsor
- AstraZeneca