Clinical trials: Cardiac Complications
Acute Kidney Injury
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial…
- Trial name
- NCT07718373
- Testing
- L-arginine
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
Growth Hormone Deficiency, Turner Syndrome
Evaluation of Convenience and Compliance of the Easypod™ Electronic Self-injector
This is an international, multicenter study involving children treated with Saizen®, a growth hormone, who will be trained to use easypod, a new electronic injector and will complete a questionnaire after 12 week of use.
- Conditions
- Growth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
- Trial name
- NCT00738205
- Volunteers
- 834 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Gastroesophageal Reflux, Apnea
Study of Erythromycin in GER-Associated Apnea of the Newborn
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective…
- Conditions
- Gastroesophageal Reflux, Apnea, Bradycardia
- Trial name
- SEGAN (NCT01825473)
- Testing
- Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Systemic Inflammatory Response Syndrome, Postoperative Shock
The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery
In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic…
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Shock, Coronary Artery Disease, Extracorporeal Circulation; Complications
- Trial name
- REMEDI (NCT03939273)
- Testing
- Vancomycin Oral, Metronidazole Oral, Ciprofloxacin Pill
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Primary Amenorrhoea, Hypothalamic Amenorrhoea
Pubertal Induction in Individuals With Hypogonadism
The investigators wish to explore the variability of uterine, breast and bone outcome markers as surrogates to assess the adequacy of exogenous oestrogen replacement in individuals with hypogonadism.
- Conditions
- Primary Amenorrhoea, Hypothalamic Amenorrhoea, Hypogonadotrophic Hypogonadism, Hypopituitarism
- Trial name
- NCT02871986
- Testing
- Routine transdermal oestrogen patch
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London
Pain, Postoperative, Respiratory Complication
Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain in Open Heart Surgeries
Postoperative pain negatively effects respiratory functions in open heart surgeries. The aim of the study is to compare the effects of thoracic epidural analgesia (TEA) and erector spinae plane block (ESPB) on postoperative pain…
- Trial name
- NCT06098859
- Testing
- Thoracic epidural analgesia, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Myocardial Infarction, Cerebral Infarction
Acute Myocardial Infarction and Acute Cerebral Infarction (AMIAC) Registry and Follow-up
A registry of consecutive patients who were admitted and diagnosed with acute myocardial infarction or acute cerebral infarction were conducted at the Guangdong General Hospital or the First Affiliated Hospital of Guangzhou…
- Conditions
- Myocardial Infarction, Cerebral Infarction, Chronic Kidney Diseases, Mortality
- Trial name
- AMIAC (NCT03166696)
- Where
- 3 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Turner Syndrome, Idiopathic Short Stature
Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature
Growth hormone treatment improves body fat distribution but also causes insulin resistance. Scientists have recently linked insulin resistance with special stores of fat in the muscles, which can be measured by magnetic resonance…
- Trial name
- NCT00121875
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Postoperative Recovery, Length of Hospital Stay
The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery
Anticholinergic drugs are common in older adults and linked to cognitive decline, frailty, longer hospital stay, and higher mortality.
- Conditions
- Postoperative Recovery, Length of Hospital Stay, Postoperative Complications
- Trial name
- NCT06349057
- Testing
- reducing anticholinergic burden
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Heart Failure, Diastolic Dysfunction
Timely Recovery After Subclinical Heart Failure
The goal of this randomized controlled trial is to assess the effectiveness of ACE inhibitors versus standard care) in reversing asymptomatic heart failure (HF stage-B) and/or diastolic dysfunction during a two-year open-label…
- Trial name
- TREASURE (NCT06341101)
- Testing
- Perindopril
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Hip Fractures
Hypobaric Lateral Spinal Anesthesia Versus General Anesthesia for the Hip Fracture Surgery
Hip fracture is a frequent pathology, involving elderly patients with many co-morbidities ; therefore, post-operative morbidity and mortality is high.
- Trial name
- RACHYP (NCT03373864)
- Testing
- Unilateral spinal anesthesia, General anesthesia
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Hospices Civils de Lyon
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Coronary Artery Disease, Aortic Valve Stenosis
MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)
MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS).
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Extracorporeal Circulation; Complications
- Trial name
- MiECS (NCT05487612)
- Testing
- Minimal Invasive Extracorporeal Circulation, Conventional cardiopulmonary bypass
- Where
- 13 sites in Canada, Germany and 4 more
- Volunteers
- 1,300 people
- Sponsor
- Aristotle University Of Thessaloniki
Radial Artery Occlusion, Radial Artery Spasm
Radial Access Data in Vascular Interventions Registry
The RADIUS study is a prospective observational registry designed to collect real-world data regarding radial and ulnar artery access in percutaneous vascular interventions.
- Conditions
- Radial Artery Occlusion, Radial Artery Spasm, Vascular Access Complications, Coronary Artery Disease
- Trial name
- RADIUS (NCT07614386)
- Testing
- Radial and Ulnar Artery Access
- Where
- Turkey (Türkiye)
- Volunteers
- 20,000 people
- Sponsor
- Mersin Medicalpark Hastanesi
Atrial Septal Defect (ASD), Dexmedetomidine
Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect
The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters.
- Conditions
- Atrial Septal Defect (ASD), Dexmedetomidine, Delirium - Postoperative, Stress Response
- Trial name
- NCT06631534
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Cardiovascular Diseases, Cardiovascular Abnormalities
Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)
The primary objective is to assess the effect of 2 dose levels of SNF472 (300 mg and 600 mg) compared to placebo on the progression of coronary artery calcium volume score over a 12-month (52 weeks) period in ESRD patients on HD
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormalities, Calcifications, Vascular, Endstage Renal Disease
- Trial name
- NCT02966028
- Testing
- SNF472
- Where
- 75 sites in United States, Spain and 1 more
- Volunteers
- 274 people
- Sponsor
- Sanifit Therapeutics S. A.
Heart Transplantation, Acute Renal Failure
Metabolic Pattern of Cyclosporine A and Acute Renal Failure
Following heart transplantation many patients develop acute renal failure in the early posttransplant phase and some are in need of renal replacement therapy for shorter or longer time.
- Trial name
- NCT00264355
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo School of Pharmacy
Acute Kidney Injury, Coronary Artery Disease
A Zero Acute Kidney Injury Strategy for Percutaneous Coronary Intervention in Patients With ChronicKidney Disease
The purpose of this study is to compare the outcomes of Percutaneous Coronary Intervention (PCI) in patients with chronic kidney disease (CKD) using smaller doses of contrast dye that are validated as being at low risk of causing…
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- Zero-AKI (NCT04928092)
- Testing
- Standard of care Ultra Low Contrast PCI
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Coronary Artery Disease, Chronic Kidney Disease
Clinical Feature and Outcome of Angiographic Coronary Artery Disease in Chronic Kidney Disease Patients
The prevalence and mortality rate of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients is high. The prevalence of coronary artery disease (CAD) in CKD population ranges from 38 to 65%, with an average of 3.3…
- Trial name
- NCT00651521
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Chang Gung Memorial Hospital
Non-small Cell Lung Cancer, Cardiovascular Complication
Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients
This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced…
- Trial name
- NCT04980716
- Testing
- Multiple cardiovascular drugs related to "Golden Triangle"
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Sun Yat-sen University
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