Clinical trials: Cardiac Complications
Diabetes Mellitus, Hypertension
Evidence-based Laboratory Test Order Sets in Primary Care
Cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.
- Conditions
- Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Fatigue
- Trial name
- NCT02950142
- Testing
- CPOE with order sets for lab testing, CPOE without order sets for lab testing
- Where
- Belgium
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Injury, Acute
A Machine Learning Prediction Model for Postoperative Acute Kidney Injury in Non-Cardiac Surgery Patients
Primary objectives of this study is to develop and validate a predictive model for acute kidney injury after non-cardiac surgery based on machine learning.
- Trial name
- NCT07030166
- Testing
- No intervention measures were used.
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lanyue Zhu
Kidney Diseases, Heart Transplantation
Safe Renal Function In Long Term Heart Transplanted Patients
The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy
- Trial name
- SAREFU (NCT00505102)
- Testing
- Everolimus
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Pulmonary Disease, Postoperative Complications
Hyperinflation Respiratory Therapies in Cardiac Surgery Patients
The purpose of this prospective randomized clinical trial is to evaluate three different types of hyperinflation respiratory therapies, Intermittent Positive Pressure Breathing (IPPB), Intermittent positive end expiratory…
- Trial name
- NCT04164173
- Testing
- EzPAP, Metaneb, Intermittent Positive Pressure Breathing (IPPB)
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney Failure, Acute, Oxidative Stress Induction
N-acetylcysteine to Prevent Renal Failure
The purpose of this study is to determine the possible effect nephroprotective of N-acetylcysteine in patients with chronic kidney disease undergoing elective coronary artery bypass grafting by serial evaluation of renal function…
- Trial name
- NCT01359722
- Testing
- N-acetylcysteine, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto do Coracao
Postoperative Delirium (POD), Postoperative Sleep Disturbance
Effects of Esketamine on the Incidence of Postoperative Delirium and Postoperative Sleep Disturbance in Elderly Patients After Major Non-cardiac Surgery
Postoperative delirium (POD) is a common surgical complication.It is associated with a range of negative outcomes such as delayed postoperative recovery,prolonged hospitalization,additional medical expenditures and higher…
- Trial name
- EPISODE (NCT06900205)
- Testing
- Esketamine, 0.9 % saline
- Where
- China
- Sponsor
- RenJi Hospital
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Acute Coronary Syndrome, Renal Failure
Adaptation Dose of Enoxaparin in Moderate Renal Failure Patients With Acute Coronary Syndrome
The objective of the VALIDE study is to validate that a 25% dose reduction of enoxaparine in patients with moderate renal failure (creatinine clearance between 30 and 50 ml/min) and hospitalized for an acute coronary syndrome…
- Trial name
- NCT00412802
- Testing
- dose adaptation of Enoxaparin, normal injection of Enoxaparine
- Where
- 9 sites in France
- Volunteers
- 67 people
- Sponsor
- French Cardiology Society
Chronic Kidney Disease, Chronic Heart Failure
Intravenous Iron in Patients With Severe Chronic Heart Failure and Chronic Kidney Disease
Recently, growing body of evidence support the finding that anemia frequently occurs in patients with chronic heart failure (CHF).
- Conditions
- Chronic Kidney Disease, Chronic Heart Failure, Anemia
- Trial name
- NCT00384657
- Testing
- iron sucrose
- Where
- 2 sites in Romania
- Sponsor
- Anemia Working Group Romania
Chronic Kidney Disease
Vitamin D Supplementation and Cardiac Hypertrophy in Chronic Kidney Disease (CKD)
Patients with Chronic Kidney Disease (CKD) are upto 3.5 times more likely to die from diseases of heart and blood vessels (Cardiovascular Disease-CVD). Vitamin D insufficiency is very common in CKD and associated with CVD.
- Trial name
- 5C (NCT01323712)
- Testing
- Vitamin D Cholecalciferol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Coronary Artery Disease, Complication of Coronary Artery Bypass Graft
Negative Pressure Dressing After Saphenous Vein Harvest
This study will test the effectiveness of negative pressure wound therapy (using the VAC Prevena device, KCI Canada Inc.) applied to the saphenous vein harvest site after Coronary Artery Bypass Grafting (CABG).
- Conditions
- Coronary Artery Disease, Complication of Coronary Artery Bypass Graft, Wound Complication
- Trial name
- NCT01698372
- Testing
- Prevena device (Group A)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Cardiovascular Collapse, Intubation Complication
The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Intubation
This prospective observational study evaluates the impact of propofol and ketamine on the risk of cardiovascular collapse during induction for endotracheal intubation in critically ill patients.
- Conditions
- Cardiovascular Collapse, Intubation Complication, Anaesthetic Complication Cardiac
- Trial name
- NCT06750939
- Testing
- propofol, ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Kocaeli City Hospital
Postoperative Pain, Chest Pain
Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery
Inadequate pain control after coronary artery bypass graft surgery increases mortality and results in a higher incidence of persistent poststernotomy pain syndrome.
- Conditions
- Postoperative Pain, Chest Pain, Coronary Artery Bypass, Sternotomy
- Trial name
- NCT04591119
- Testing
- Transversus Thoracic Muscle Plane Block, Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Muğla Sıtkı Koçman University
Acute Kidney Injury
A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
The purpose of this study is to determine whether THR-184 when administered around the time of cardiac surgery that requires cardiopulmonary bypass can prevent or ameliorate the development of acute kidney injury.
- Trial name
- NCT01830920
- Testing
- THR-184
- Where
- 41 sites in United States, Canada
- Volunteers
- 452 people
- Sponsor
- Thrasos Innovation, Inc.
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction
CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State
The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60…
- Conditions
- Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities
- Trial name
- CERBERUS (NCT06133842)
- Testing
- Intra-op EEG and CO data collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Kidney Failure, Congenital Heart Defects
Chronic Kidney Disease in Teenagers With Congenital Cardiac Disease
The prevalence of chronic kidney injury (CKD) following cardiac surgery during childhood is not known, but there is evidence of CKD in young adults.
- Trial name
- PRECARDIO (NCT01845402)
- Testing
- blood and urine samples
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Delirium on Emergence
Efficacy of Dexmedetomidine Versus Clonidine to Control Delirium in Patients Undergoing CABG
This prospective, randomised, double blinded, controlled clinical trial will be conducted in 147 patients between 60 yr and 70 yr , ASA physical status II and III, undergoing CABG.
- Trial name
- NCT03477994
- Testing
- Dexmedetomidine, Clonidine
- Where
- Egypt
- Volunteers
- 147 people
- Sponsor
- Ain Shams University
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms
- Trial name
- PICSI-H (NCT04283994)
- Testing
- Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 756 people
- Sponsor
- University of Washington
Coronary Angiography, Radial Artery Occlusion
The Prevalence of Radial Artery Occlusion in Diagnostic Cardiac Catheterization and Percutaneous Intervention
The purpose of this study is to establish the rate of radial artery occlusion post transradial cardiac catheterization through different modalities.
- Trial name
- NCT01996553
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Jesse Brown VA Medical Center