Clinical trials: Cardiac Complications
Cardiac Surgical Procedures, Retained Blood Syndrome
CPPF After General Cardiac Surgery
In two randomized clinical trials the investigators have demonstrated that continuous postoperative pericardial flushing (CPPF) therapy can reduce postoperative blood loss and bleeding-related complications after cardiac surgery…
- Conditions
- Cardiac Surgical Procedures, Retained Blood Syndrome, Cardiac Tamponade, Postoperative Hemorrhage
- Trial name
- FLUID (NCT05308589)
- Testing
- CPPF
- Where
- 4 sites in Netherlands
- Volunteers
- 164 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiopulmonary Arrest, Mechanical Ventilation Complication
Evaluating the Performance of Invasive Ventilation During Specialized CPR
Describe the ventilation patterns, describe the evolution of ventilation over time and describe the safety data for two strategies of ventilation (volume or pression modes) during specialized cardiopulmonary resuscitation of…
- Trial name
- NCT06175689
- Volunteers
- 400 people
- Sponsor
- University Hospital, Angers
Primary or Metastatic Hepatic Adenocarcinoma
Cardiac Output Optimization on Postoperative Complications in Major Hepatic Surgery
Major hepatectomies are high-risk surgeries offered more and more frequently for the curative treatment of primary or secondary liver cancer, and for complex cases, representing a real challenge for medical teams.
- Trial name
- OPTILIVER (NCT04655885)
- Testing
- Optimization of cardiac flow by base water-electrolyte supply, Control arm
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Institut Paoli-Calmettes
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Cognitive Dysfunction
n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery
Background: Delirium and long-term cognitive dysfunction (CD) are important complications of major surgery and intensive care treatment.
- Trial name
- NCT00757913
- Testing
- n-3 enriched nutrition
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Basel, Switzerland
Ischemic Heart Disease, Valvular Heart Disease
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its…
- Conditions
- Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
- Trial name
- THERMIC-4 (NCT05996120)
- Testing
- Hypothermic Cardiopulmonary Bypass, Normothermic Cardiopulmonary Bypass
- Where
- 11 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Intrauterine Growth Restriction, Cardiopulmonary Disease
IUGR, Respiratory Muscle Function, and Exercise Capacity in Childhood
The study hypothesis is that intrauterine growth restriction (IUGR) may have long-term effects on respiratory muscle (RM) function, thus leading to reduced exercise capacity later in life.
- Trial name
- NCT03368755
- Testing
- Cardiopulmonary Exercise Testing, Respiratory Muscle Strength and Endurance
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University of Patras
Congenital Heart Disease, Airway Complication of Anesthesia
Video Laryngoscopy Versus Direct Laryngoscopy for Nasotracheal Intubation
The aim of this study is to perform a pilot study investigating the first attempt intubation success rate differing between video laryngoscope nasotracheal intubation and direct laryngoscope nasotracheal intubation.
- Trial name
- NCT05902013
- Testing
- laryngoscopy
- Where
- Austria
- Volunteers
- 152 people
- Sponsor
- Medical University of Vienna
Postoperative Cognitive Dysfunction
Feasibility and Acceptability of Home-based Computerised Cognitive Training After Cardiac Surgery
The aims of this study are to (1) evaluate the feasibility and acceptability of a home-based computerised cognitive training programme in the postoperative cardiac surgical population, and (2) estimate measures of precision about…
- Trial name
- FACCT (NCT05298540)
- Testing
- Home-based computerised cognitive training with BrainHQ
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Barts & The London NHS Trust
Cardiovascular Disease, Preeclampsia
Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia
This study will compare two arms in a randomized clinical trial of cardiovascular risk prevention in women with a history of preeclampsia.
- Conditions
- Cardiovascular Disease, Preeclampsia, Hypertension, Post-partum Weight Retention
- Trial name
- HH4M (NCT02147626)
- Testing
- Web-based educational and motivational modules, Information and Screening Group
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Metabolic Syndrome, Hypertension
Complications in Hypertension and Obesity
The study in aimed to investigate epidemiology of risk factors in Russian Federation its prognostic value aimed on acceptance of national specific definition of metabolic syndrome and guidelines for its management.
- Conditions
- Metabolic Syndrome, Hypertension, Obesity, Dyslipidemia
- Trial name
- NCT00552292
- Where
- Russia
- Volunteers
- 30,000 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Post Operative Delirium, Post Operative Pain
Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery.
- Conditions
- Post Operative Delirium, Post Operative Pain, Post-Op Complication, Post-cardiac Surgery
- Trial name
- IVACS (NCT06613178)
- Testing
- acetaminophen
- Where
- 8 sites in Canada
- Volunteers
- 1,100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Kidney Injury, Uremic; Toxemia
Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury
Acute kidney injury (AKI) is a frequent disease in conventional hospital departments and in intensive care units. It's associated with a high risk to develop chronic kidney disease (CKD), even after a single small AKI episode.
- Conditions
- Acute Kidney Injury, Uremic; Toxemia, Vascular Dysfunction, Cardiac Dysfunction
- Trial name
- VASC-AKI (NCT05659589)
- Testing
- blood sample
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Prolonged Apnea, Prolonged Bradycardia
DTaP and Apnea/Bradycardia in Preterm Infants
The purpose of this study is to examine the relationship between receipt of DTaP and the occurrence of prolonged episodes of apnea and bradycardia in preterm infants, while employing a random control study design and an objective…
- Trial name
- PIA (NCT00482781)
- Testing
- Infanrix, Pediatrix
- Where
- 10 sites in United States
- Volunteers
- 191 people
- Sponsor
- American SIDS Institute
Acute Decompensated Heart Failure
Impact of Hypertonic Saline Solution on Acute Decompensated Heart Failure
Acute decompensated heart failure (HF) is one of the most common cardiologic issues in emergency departments. Loop diuretics have long been recognized as the key for the treatment of Acute Decompensated Heart Failure…
- Trial name
- HSS (NCT05298098)
- Testing
- Hypertonic Saline Solution
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Major Adverse Cardiac Events, Cerebrovascular Accident
Construction of a Prediction Model for MACCE in Elderly Patients After Elective Non-cardiac Surgery
Severe cardiovascular and cerebrovascular complications, including cardiac death, non-fatal angina/myocardial infarction, non-fatal heart failure, stroke, severe arrhythmia, etc., are one of the main types of postoperative…
- Conditions
- Major Adverse Cardiac Events, Cerebrovascular Accident, Postoperative Complications, Models
- Trial name
- NCT06391632
- Testing
- Revised Cardiac Risk Index
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
PONV, Blood Pressure
Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting
Intraoperative hypotension is associated with postoperative nausea and vomiting (PONV). Even though the exact mechanism linking PONV and hypotension is still unclear, a reduced intestinal tissue perfusion might trigger nausea and…
- Conditions
- PONV, Blood Pressure, Postoperative Recovery
- Trial name
- SICK (NCT05596695)
- Testing
- Minimizing blood pressure variability
- Where
- Austria
- Volunteers
- 272 people
- Sponsor
- Medical University of Vienna
Obesity, Pregnancy Complications
NT-proBNP Levels and Obesity in Pregnancy
A screening modality to help categorize obese pregnant women as high or low probability for heart failure would be helpful in the evaluation of the obese pregnant women with dyspnea.
- Conditions
- Obesity, Pregnancy Complications, Peripartum Cardiomyopathy
- Trial name
- NCT04049136
- Testing
- NT-proBNP
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Duke University
Multiorgan Failure, Perfusion; Complications
NIRS and DO2i Correlation
This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.
- Trial name
- NCT03281707
- Testing
- NIRS, DO2i
- Volunteers
- 50 people
- Sponsor
- Centro Cardiologico Monzino
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.