Clinical trials: Cardiac Disorder
Cardiovascular Diseases
Heredity and Phenotype Intervention (HAPI) Heart Study
Cardiovascular disease (CVD) is the leading cause of death in the United States and many people that die of heart disease have no previous symptoms.
- Trial name
- HAPI (NCT00664040)
- Testing
- Aspirin, Cold Pressor Test, High Fat Meal
- Volunteers
- 868 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Coronary Heart Disease, Periodontal Diseases
Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart…
- Trial name
- NCT04127474
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Cardiac Arrest
Tele-Support for Emergency Medical Technicians
In this manikin-based simulation study the impact of tele-support during a simulated pediatric out-of-hospital cardiac arrest scenario on emergency medical technicians' guideline adherence, on gaze behavior as well as on…
- Trial name
- POHCA (NCT06362850)
- Testing
- Tele-support
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy, Dysautonomia
Effects of Osteopathic Technique on Autonomic Nervous System Activity
Cranial osteopathic manipulation technique for brain and cranial nerve function, known as the fourth ventricle compression (CV4), has been recognized.
- Trial name
- Osteo (NCT06554834)
- Testing
- CV4 + RR, CV4, EEG/HRV/RSA (Electroencephalography, Heart Rate Variability, Respiratory Sinus Arrhythmia) Monitoring using Infiniti System
- Where
- Poland
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- SomaticMed
Heart Failure, Diastolic
Cardiac Magnetic Resonance Tomography for Heart Failure With Preserved Ejection Fraction
The diagnosis of heart failure with preserved ejection fraction has so far been made primarily according to criteria determined by echocardiography, or invasively by measuring the left ventricular filling pressures.
- Trial name
- NCT05322109
- Testing
- CMR
- Where
- Germany
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- German Heart Institute
Cerebral Hypoxia
The Effects of Hypobaria vs Hypoxia on Cerebral Functions.
The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.
- Trial name
- Hypoxia (NCT03303118)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Heart Disease
Eicosapentaenoic Acid (EPA)and Docosahexaenoic Acid Study
The goal of the study is to test the efficacy of an EPA-enriched oil made by DuPont versus a DHA-enriched oil, a standard fish oil preparation, and olive oil placebo in a double-blind, randomized, placebo-controlled trial.
- Trial name
- NCT01400490
- Testing
- EPA-DHA Study
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research Associates
Heart Failure
Cardiac Function and Inspiratory Muscles Performance
The purpose of this study is to determine whether ejection fraction and peak oxygen uptake have correlation on inspiratory muscle strength, chest wall volumes and quality of life in individuals with heart failure.
- Trial name
- NCT02763982
- Testing
- Physical evaluation
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Incidence of Atrial Fibrillation in Adults Aged ≥ 65
Opportunistic Screening in Pharmacies for Atrial Fibrillation in Seniors (>65 Years)
Atrial fibrillation (AF) is the most common arrhythmia in Germany and is associated with an increased risk of thromboembolic stroke. The risk to suffer from AF increases with age.
- Trial name
- AF-Stroke (NCT03004859)
- Where
- Germany
- Volunteers
- 7,606 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Diabetes, Atrial Fibrillation (AF)
Unrecognised Comorbidity Detection in Hospitalised Patients
Over two million people in the UK are unaware that they're living with a long-term (chronic) health condition, such as diabetes or a heart problem.
- Conditions
- Diabetes, Atrial Fibrillation (AF), Cardiac Disease
- Trial name
- CODETECT (NCT06881797)
- Where
- United Kingdom
- Volunteers
- 4,500,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Cancer, Coronary Artery Disease
Calibration of MR and PET-MR Imaging Protocols at RIC
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the…
- Trial name
- NCT02249520
- Testing
- PET-MR imaging on Biograph mMR scanner, MR-only imaging on Biograph mMR scanner, MR imaging on the Siemens Vida 3T MR scanner
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
CHD, AMI
Lifestyle Intervention in a General Population for Prevention of Ischaemic Heart Disease
In spite of declining trend coronary heart disease (CHD) is still a leading cause of morbidity and mortality. Many years of epidemiological research have identified several risk factors for CHD.
- Conditions
- CHD, AMI, CVD, Type 2 Diabetes
- Trial name
- NCT00289237
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 61,301 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Ischemic Heart Disease, Atherosclerosis
Graft Patency as a Predictor of Health-related Quality of Life.
The health-related quality of life questionnaire "EQ-5D" has been collected in connection with several interventional and observational studies where the no-touch vein harvesting technique in CABG has been used.
- Trial name
- NCT02547194
- Where
- Sweden
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Örebro County Council
Amyotrophic Lateral Sclerosis, Neuromuscular Diseases
Emotion Processing Among Patients With ALS
The goal of this observational study is to learn about the emotional perception in people with ALS disease compared to people with other neuromuscular disease and healthy controls.
- Conditions
- Amyotrophic Lateral Sclerosis, Neuromuscular Diseases, ALS, Motor Neuron Disease
- Trial name
- NCT06566651
- Testing
- Emotion Discrimination Task (EDT)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cardiovascular Disease, Pulmonary Arterial Hypertension
Effect of BIA 5 1058 on Cardiac Repolarization
The purpose is to evaluate the effect of single therapeutic (400 mg) and supratherapeutic (1200 mg) doses of BIA 5-1058 on the time-matched change from baseline in placebo-adjusted interval corrected (QT) for heart rate (HR)
- Conditions
- Cardiovascular Disease, Pulmonary Arterial Hypertension, Heart Failure
- Trial name
- NCT03489005
- Testing
- BIA 5-1058, Moxifloxacin 400 mg
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Heart Transplant Failure and Rejection, Heart Failure
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a…
- Conditions
- Heart Transplant Failure and Rejection, Heart Failure, Heart Diseases, Heart Failure，Congestive
- Trial name
- HEARTBiT (NCT03575910)
- Where
- 4 sites in United States, Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Bladder Disorder, Neurogenic
Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Heart rate variability (HRV) is an important indicator of cardiac autonomic function and predictor of cardiac mortality and of all-cause mortality.
- Trial name
- HRV/Botox (NCT01337024)
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Cardiovascular Diseases, Death, Sudden, Cardiac
Drug-Induced Sudden Death & Ventricular Arrhythmia
To investigate the relationship between the use of prescription drugs and the occurrence of ventricular arrhythmia and sudden death.
- Conditions
- Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Diseases, Ventricular Arrhythmia
- Trial name
- NCT00102180
- Volunteers
- 31,000,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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