Clinical trials: Cardiac Dysfunction
Acute Coronary Syndrome, Acute Coronary Syndrome With Renal Dysfunction
Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction
The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).
- Trial name
- NCT04998227
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Cardiovascular Diseases, Diabetes
Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
To determine associations between dietary factors and risk of major chronic diseases and their risk factors
- Conditions
- Cardiovascular Diseases, Diabetes, Metabolic Syndrome, Cancer
- Trial name
- NCT03221127
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Coronary Microvascular Dysfunction, Ischemic Non-Obstructive Coronary Artery Disease
MCG as a Noninvasive Diagnostic Strategy for Suspected Coronary Microvascular Dysfunction
According to the Women's Ischemic Syndrome Evaluation database, there are approximately 3 to 4 million women and men who present with signs and symptoms that are suggestive of myocardial ischemia, however they have no obstructive…
- Trial name
- MICRO (NCT05150054)
- Testing
- CardioFlux
- Where
- 4 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Genetesis Inc.
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes
To study on the Postoperative Cognitive Dysfunction: Correlations With Olfactory Dysfunction and Related Gene Changes.To explore whether the olfactory dysfunction could be used as a predictor of POCD and to provide reference for…
- Trial name
- NCT02992600
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Han Yuan
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Syndrome X
Syndrome X and Endothelial Dysfunction
Cardiac syndrome X is characterized by angina, positve stress test, and patent coronary angiography, and its probable mechanism is microvascular dysfunction associated with endothelial dysfunction.
- Trial name
- NCT00190086
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Delirium
Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower…
- Trial name
- NCT00417664
- Testing
- Dexmedetomidine, Propofol, Midazolam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Aging, Healthy
Healthy Aging Through Dietary Intervention
To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals
- Trial name
- NCT05782309
- Testing
- Flavanol
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Arteriosclerosis, Endothelial Dysfunction
Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus
The purpose of this research study is to see the effect of taking Aged Garlic Extract (AGE) on the progression of coronary plaque, a condition called atherosclerosis, in people diagnosed with Diabetes.
- Conditions
- Coronary Arteriosclerosis, Endothelial Dysfunction, Type 2 Diabetes Mellitus
- Trial name
- NCT03931434
- Testing
- Aged Garlic Extract (AGE)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may…
- Conditions
- Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction
- Trial name
- PREFER-HF (NCT03480633)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiac Arrest, Cognitive Function
Brain Function After Cardiac Arrest (Measured With FMRI and Cognitive Tests)
The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time…
- Trial name
- BRAINnHEART (NCT03579498)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uppsala University
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Type 2 Diabetes, Pregnancy
Fat Metabolism in Pregnancy and Neonatal Heart Function in Diabetes
Background: The health of the next generation is likely programmed in the womb (i.e.in utero), and our understanding of how that programming happens will allow us to favorably influence the health of future generations.
- Trial name
- NCT01346527
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Transposition Great Arteries, Executive Dysfunction
The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease
In the landmark Boston Circulatory Arrest Study, neurologic and developmental status was measured following infant heart surgery and then prospectively at ages 1, 2.5, 4, 8, and 16 years, with findings of significant…
- Trial name
- BCAS-Adult (NCT03073122)
- Testing
- Brain MRI, neurocognitive and psychological testing
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Postoperative Cognitive Dysfunction
POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
- Trial name
- NCT03084393
- Where
- China
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham