Clinical trials: Cardiac Dysrhythmia
Atrial Fibrillation
Study to Assess the Safety, Tolerability, Pharmacokinetic of Thrv-1268
This is a single-center, randomized, double-blind, placebo-controlled study to be conducted in 2 parts: single ascending dose (SAD) incorporating a food effect arm and multiple ascending dose (MAD).
- Trial name
- NCT06507839
- Testing
- THRV-1268
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Arrythmia, Health Education
Efficacy of Gamification With Escape-Room for Arrhythmia Identification in Critical Patients
Introduction: Health education provided through the escape-room is still a recent approach in educational methodology and tends to be a strategy that benefits nursing students, particularly in gaining knowledge and skills.
- Conditions
- Arrythmia, Health Education, Escape-Room
- Trial name
- NCT06266845
- Testing
- In-person Escape Room, Virtual Escape-Room
- Where
- Brazil
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Cardiovascular Diseases, Heart Failure
Development of CIRC Technologies
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy
- Trial name
- CIRC (NCT05654272)
- Testing
- MRI
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Arrhythmias, Cardiac
Risk Stratifications for Patients With Palpitations
the aim of the study is to early diagnose and early proper mangment of those patients who have palpitations specially of cardiac origin
- Trial name
- NCT06103305
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sleep Deprivation
Protective Effect of Statin on Sleep Deprivation
This study aimed to investigate the effect of 48-h sleep deprivation on heart rate variability (HRV) in young healthy people and the protective effect of statin on arrhythmia and HRV.
- Trial name
- NCT02496962
- Testing
- Atorvastatin
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shi Yang
Rumination
Effect of Environment on the Central and Peripheral Nervous System
The main goal of this study is to understand how different environments influence both mental responses, like overthinking (rumination), and physical reactions, such as heart rate and blood pressure, after a challenging task.
- Trial name
- RUMI (NCT06778356)
- Testing
- Built environment, Natural environment
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Heart Failure, Arrhythmias, Cardiac
Evaluation of ECG Transmission and AI Models Using Apple Watch ECGs and Symptoms Data Collected Using a Mayo iPhone App
The purpose of the study is to determine if the Electrocardiograms (ECGs) and symptoms data obtained from an Apple Watch and transmitted to Mayo Clinic are of sufficient quality to guide a person's care.
- Conditions
- Heart Failure, Arrhythmias, Cardiac, Health Care Utilization
- Trial name
- NCT05324566
- Where
- United States
- Volunteers
- 4,163 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Hypertension
Home-Based Screening for Early Detection of Atrial Fibrillation in Primary Care Patients Aged 75 Years and Older
Atrial fibrillation (AF) is a major treatable risk factor for stroke, but it may be hard to detect because it is frequently silent and intermittent.
- Trial name
- SCREEN-AF (NCT02392754)
- Testing
- Screening: Intervention - Atrial fibrillation screening (ZIO XT ECG monitor, Watch-BP)
- Where
- 28 sites in Canada, Germany
- Volunteers
- 856 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Arrhythmia
Single Ascending Dose of GAP-134 as a 24-hour IV Infusion in Healthy Japanese Males
This is a study of GAP-134, an antiarrhythmic di-peptide. This study will provide an initial assessment of the safety, tolerability, and pharmacokinetics (PK) of GAP-134 after administration of ascending single intravenous (IV)…
- Trial name
- NCT00543946
- Testing
- GAP-134
- Where
- Japan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Atrial Fibrillation, Hypertension
Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers
The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent…
- Trial name
- NCT00225667
- Testing
- Irbesartan
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Connolly, Stuart, M.D.
Atrial Fibrillation (AF)
PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its…
- Trial name
- POBI-PFA (NCT06929897)
- Testing
- Pulmonary Vein Isolation, Additional Left Atrial Posterior Wall Ablation, Non-PV trigger test
- Where
- South Korea
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Heart Failure, Diffuse Fibrosis
Using Cardiovascular Magnetic Resonance Tissue Characterisation and Wearable Technology to PREDICT Clinical Outcomes, Response to Therapy and Arrhythmias in Hospitalised Heart Failure Patients
150 patients admitted to University Hospital Southampton with heart failure will undergo comprehensive Cardiovascular Magnetic Resonance (CMR) imagining during their admission and continuous heart rhythm monitoring using wearable…
- Conditions
- Heart Failure, Diffuse Fibrosis, Focal Fibrosis, Arrythmia
- Trial name
- PREDICT-HF (NCT03689426)
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hypertension, Atrial Fibrillation
Impact of Best Practice Alerts in Cardiology Outpatient Clinics
This quality improvement intervention seeks to implement two Best Practice Alerts (BPAs) for use in cardiology clinics while simultaneously evaluating the impact of each BPA- one for patients with uncontrolled blood pressure and…
- Trial name
- NCT02436421
- Testing
- Best Practice Alert based in the Electronic Medical Record
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure, Type 2 Diabetes
Transform: Teaching, Technology, and Teams
This initiative supports a quality improvement effort evaluating the use of strategies (including technology-based decision support, referral to a virtual GDMT team, and general educational tools/resources for clinicians and…
- Conditions
- Heart Failure, Type 2 Diabetes, Atrial Fibrillation
- Trial name
- T3 (NCT05572814)
- Testing
- Decision Support, Referral
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- American College of Cardiology
Sudden Cardiac Death, Cardiomyopathies
Sudden Cardiac Death - Screening Of Risk Factors
The investigators have created a way of quickly collecting information in a large scale young population regarding the presence of some severity indicators that may allow us to classify them into: seemingly "low risk" and…
- Conditions
- Sudden Cardiac Death, Cardiomyopathies, Channelopathies
- Trial name
- SCD-SOS (NCT01845909)
- Testing
- ECG and survey screening
- Where
- Portugal
- Volunteers
- 15,351 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Atrial Fibrillation
Validation Study of Frontier X Plus (FX+) Device
The main objective of this study is to validate the specificity and sensitivity of FX+ detecting atrial fibrillation (AF) in both AF and non-AF subjects using a comparative approach, which involves using both a US FDA-cleared…
- Trial name
- NCT06471764
- Testing
- FX+ and 12-Lead ECG Recording
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Fourth Frontier Technologies Pvt Ltd.
Arrhythmia Recognition, Patient Safety Attitudes
Case-Based Collaborative Learning for Arrhythmia Recognition in Novice Intensive Care Nurses
This randomized controlled trial evaluates the effectiveness of case-based collaborative learning (CBCL) in improving arrhythmia recognition and patient safety attitudes among novice intensive care nurses.
- Conditions
- Arrhythmia Recognition, Patient Safety Attitudes, Arrhythmia
- Trial name
- NCT07780448
- Testing
- Case-Based Collaborative Learning-Based Arrhythmia Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Naile ALANKAYA
Cardiac Arrhythmias
Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics
Among the adjuvants to local anaesthetics (LA), the enzyme hyaluronidase is most often used as a diffuser agent of the LA in ophthalmic anaesthesia.
- Trial name
- NCT01719978
- Testing
- 3.6mL 2% Mepivacaine with 1:100,000 epinephrine, Lower Third Molar Extraction, Hyaluronidase
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mauricio Jose Tornelli
Bradycardia, Atrial Tachyarrhythmia
Evaluating the Electro Magnetic Interference of Using Tablet and Smart Phone on Leadless Pacemaker (MICRA)
The purpose of this study is to evaluate the effects that electromagnetic field exposure from using a tablet and smart phone have on a leadless pacemaker (MICRA device).
- Trial name
- MICRA (NCT02758210)
- Testing
- Use of a Tablet, Use of a Smart Phone
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University