Clinical trials: Cardiac Failure
Heart Failure, Congestive
Skeletal Muscle Dysfunction in Heart Failure
Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.
- Trial name
- NCT00156234
- Testing
- One-knee extension ergometer
- Where
- 2 sites in Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Chronic Illness, Heart Failure - NYHA II - IV
An Optimization Pilot to Optimize An Early Palliative Care Intervention for Advanced Heart Failure
Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this randomized factorial pilot trial is to identify feasibility, acceptability, and preliminary efficacy of components of an…
- Trial name
- UPHOLDS (NCT05879887)
- Testing
- UPHOLDS (Utilizing Palliative Care for Heart Failure Optimized using Lay Navigators to Decrease Suffering)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Congestive Heart Failure (CHF)
CHF Management Using Telemedicine
The overall objective of this study is to improve clinical outcomes and quality of life for congestive heart failure (CHF) patients by integrating a readily available, low cost technology - the telephone - into coordinated CHF…
- Trial name
- NCT00309764
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Failure
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins
Heart failure (HF) is a leading cause of morbidity and mortality in the United States with the incidence and prevalence of the disease on a continual rise.
- Trial name
- NCT01097785
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
CRT Non-Response, LBBB
Left Ventricular Myocardial Work for Predicting Response to CRT
This study aims to establish the normal reference values for left ventricular myocardial work in healthy Chinese adults and the influencing factors.
- Conditions
- CRT Non-Response, LBBB, HF - Heart Failure, Healthy Adult
- Trial name
- CARE-MW (NCT07319065)
- Testing
- Ultrasound machine
- Where
- 82 sites in China
- Volunteers
- 3,240 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Heart Failure (HF)
A Study on the Correlation Between Cardiac-Cerebral Oxygenation Reserve and Cognitive Function Changes in Heart Failure Patients
At different stages of heart failure (HF), the cardiac and cerebral oxygen reserve exhibits varying degrees of decline due to chronic hypoxia and microvascular dysfunction caused by reduced cardiac output, leading to cognitive…
- Trial name
- NCT07485816
- Testing
- breathing training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Periodic Breathing, Heart Failure
The Cyclocapnic Method for Measurement of Chemosensitivity
We aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli.
- Trial name
- NCT01049256
- Testing
- carbon dioxide
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pulmonary Edema
Measurements of Doppler Signals Noninvasively From the Lung in Congestive Heart Failure
The purpose of this study is to evaluate the lung Doppler signals in left HF patients with and without pulmonary congestion (i.e.
- Trial name
- NCT01940328
- Testing
- Transchoracic ultrasound Doppler
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Echosense Ltd.
Left Ventricular Failure, Unspecified
Daily Life Activities in Patients Treated With Continuous-Flow Left Ventricular Assist Devices
Investigation of oxygen uptake during daily life activities in HF patients with and without LVADs.
- Trial name
- Act-VAD (NCT04732039)
- Testing
- Measurement of peak oxygen uptake
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Corronary Death, Intracerebral Haemorrhage
- Trial name
- IP4 (NCT01937065)
- Testing
- No treatment
- Where
- United Kingdom
- Volunteers
- 1,937,360 people, healthy volunteers welcome
- Sponsor
- University College, London
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End Stage Heart Failure
Impact of LVAD Implantation on Micro- and Macrovascular Function
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions.
- Trial name
- LVAD (NCT02174133)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiac Insufficiency
Safety and Preliminary Efficacy Study of EE001 in Health/Patients Adults with Mild, Moderate, or Severe (NYHA II-IV) Cardiac Insufficiency
This study is a single-center, randomized, open, exploratory, drug-safety IIT study of EE001 in normal adults/patients with mild, moderate, or severe (grades II-IV) cardiac insufficiency.
- Trial name
- NCT06884111
- Testing
- EE001，70-105ml per day by IV
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Dyspnea, Heart Failure
Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)
The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.
- Trial name
- NCT03831204
- Testing
- biopac, prognostic scores
- Where
- Tunisia
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Heart Failure With Preserved Ejection Fraction
Ventricular-Vascular Coupling in Heart Failure
This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e.
- Trial name
- NCT00207220
- Testing
- arterial tonometry, echocardiography
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Assessing Systemic Circulation and LV Performance in Adults
Background There are significant limitations in the current approaches to assessing 2 important areas of cardiovascular physiology - the systemic circulation and left ventricular (LV) performance.
- Trial name
- NCT04347655
- Testing
- handgrip test
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Inflammation, Heart Failure
Beer, Marathon, Genetics, Inflammation and the Cardiovascular System: Be-MaGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with consumption of polyphenols.
- Conditions
- Inflammation, Heart Failure, Sudden Cardiac Death
- Trial name
- Be-MaGIC (NCT00933218)
- Testing
- polyphenols (non-alcoholic beer), beverage without polyphenols
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
To Search for Biomarkers Associated With Ischemic Heart Failure, To Explore the Relationship Between Intestinal Flora and Ischemic Heart Failure
Correlation of Intestinal Flora and Metabolomics in Patients With Ischemic Heart Failure
To provide new ideas for the treatment of patients with ischemic heart failure, this study is to search for differential metabolic markers associated with ischemic heart failure and to study the influence of fecal flora on the…
- Trial name
- NCT04962763
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Heart Failure, Cardiac Resynchronization Therapy
Narrow QRS HF Patients Assessed by ECG Belt
The purpose of this study is to quantitate electrical dyssynchrony in heart failure (HF) patients with a narrow QRS complexes (≤ 130 ms) using the ECG Belt.
- Trial name
- NCT03367104
- Testing
- ECG Belt
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Allina Health System