Clinical trials: Cardiac Flow
Hemolysis Intravascular, Acute Decompensated Heart Failure
HEMolysis in a Percutaneous Axial Flow LVAD, Effects of Pentoxifylline in a Randomized Controlled Trial
Temporary mechanical circulatory support devices are increasingly used for short-term support in patients with decompensated cardiogenic shock. Recently, a new axial flow pump has become widely available with the Impella System.
- Trial name
- NCT04391231
- Testing
- Pentoxifylline Oral Product
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Disease
Assessing the Efficacy of CARDIOgoniometry (CGM) to Determine Physiologically Significant Stenosis in Patients With Stable Coronary Artery Disease in Comparison to Fractional FLOW Reserve - CARDIOFLOW
The CARDIOFLOW study compares the standard test, a pressure wire test called fractional flow reserve (FFR), with a new method that is based on taking a detailed "3D" ECG called Cardiogoniometry (CGM).
- Trial name
- CARDIOFLOW (NCT02815631)
- Testing
- Cardiogoniometry (CGM), Fractional Flow Reserve (FFR)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Disease
Prognostic Impact of Lesion-specific Hemodynamic Index in Patients With Coronary Artery Disease
The investigators aim to investigate the additive prognostic value of lesion-specific hemodynamic index such as ΔFFR, non-hyperemic pressure ratio such as RFR, over % diameter stenosis and FFR according to treatment strategy, and…
- Trial name
- PRIME-FFR (NCT05250557)
- Testing
- Fractional flow reserve
- Where
- South Korea
- Volunteers
- 2,429 people
- Sponsor
- Seoul National University Hospital
NonST Elevation Myocardial Infarction
FAMOUS-NSTEMI MRI Sub-Study
BACKGROUND: Non-ST-segment elevation myocardial infarction (NSTEMI) is the commonest type of acute coronary syndrome (ACS) and has a poor long-term prognosis.
- Trial name
- NCT02073422
- Testing
- Fractional flow reserve, Magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- NHS National Waiting Times Centre Board
Dilated Cardiomyopathy, Thrombosis
Intraventricular Stasis in Non Ischemic Dilated Myocardiopathy
This study is designed to quantify the ventricular stasis in patients with non-ischemic dilated cardiomyopathy by post-processing of 2D color Doppler echocardiography images in order to establish the relationship between…
- Conditions
- Dilated Cardiomyopathy, Thrombosis, Stroke
- Trial name
- ISBIDCM (NCT03415789)
- Testing
- Doppler echocardiogram exam, Cardiac Magnetic Resonance, Brain Magnetic Resonance
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Chronic Obstructive Pulmonary Disease, Acute Coronary Syndromes
Screening for Chronic Obstructive Pulmonary Disease in Patients With Acute Coronary Syndromes
Several studies and registries suggested that the concomitant presence of acute coronary syndromes (ACS) and chronic obstructive pulmonary disease (COPD) is significantly associated with poor prognosis.
- Trial name
- SCAP (NCT02324660)
- Testing
- screening test
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- University Hospital of Ferrara
Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction
Assessment of Coronary Flow Reserve by Doppler Flow WIre in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Differences Between the Loading Dose of Prasugrel and Ticagrelor .
Study design Investigators aim to perform a prospective, single-center, investigator-initiated, randomized study to compare the Adenosine-induced coronary vasodilatation after the loading dose of Ticagrelor either Prasugrel…
- Conditions
- Acute Coronary Syndrome, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction, Unstable Angina
- Trial name
- NCT02032303
- Testing
- Assessment of coronary flow reserve, Percutaneous Coronary Intervention, Ticagrelor loading
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Azienda Policlinico Umberto I
Coronary Artery Disease
Vascular Function on the First Day After Cardiac Surgery
This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique.
- Trial name
- NCT02001090
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease, Plaque
Pd/Pa vs iFR™ in an Unselected Population Referred for Invasive Angiography
Instantaneous wave-free ratio (iFR™) is a novel non-hyperaemic index of the functional significance of a coronary stenosis. Previous studies have shown variable levels of correlation with the established hyperaemic index FFR.
- Conditions
- Coronary Artery Disease, Plaque, Atherosclerosis, Fractional Flow Reserve
- Trial name
- VERIFY2 (NCT02377310)
- Where
- United Kingdom
- Volunteers
- 197 people
- Sponsor
- Golden Jubilee National Hospital
Myocardial Infarction
Functional Coronary Angiography Guided Revascularization in STEMI
The goal of this multicenter randomized clinical trial is to test the superiority in terms of efficacy of the Angiography-derived fractional flow reserve (AIR) over that based on conventional angiography (ANGIO) strategy in the…
- Trial name
- AIR-STEMI (NCT05818475)
- Testing
- Angiography-guided PCI, Angiography-derived FFR PCI indication and planning
- Where
- 22 sites in Italy, Pakistan
- Volunteers
- 1,823 people
- Sponsor
- University Hospital of Ferrara
Coronary Artery Disease, Coronary Disease
Sensor-equipped Ultrathin Pressure Microcatheter Versus Pressure Wire for Physiological Measurements
TruePhysio pressure microcatheter is a novel device for evaluating the functional significance of coronary stenosis, and its safety and efficacy on the measurement of hyperemic index have been validated in the previous SUPREME…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia
- Trial name
- SUPREME II (NCT05417763)
- Testing
- Randomized physiological measurements by the two systems
- Where
- 11 sites in China
- Volunteers
- 487 people
- Sponsor
- Insight Lifetech Co., Ltd.
Acute Kidney Injury, Cardiorenal Syndrome
Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
- Trial name
- NCT03753607
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Giessen
Coronary Heart Disease
Determination of Coronary Flow Reserve by Dynamic Myocardial Perfusion Scintigraphy
Because of its availability, non-invasiveness, and high diagnostic performance, myocardial perfusion tomoscintigraphy has become a standard tool for the detection, characterization and monitoring of coronary artery disease.
- Trial name
- ERCAD (NCT03326167)
- Testing
- Myocardial Perfusion Imaging by Single Photon Emission Computed Tomography (MPI SPECT)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Disease, Myocardial Ischemia
Multivessel TALENT
Multivessel TALENT is a prospective, randomized, multi-center study comparing clinical outcomes between SUPRAFLEX Cruz and SYNERGY in approximately 1550 patients with de-novo three vessel disease undergoing percutaneous coronary…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- NCT04390672
- Testing
- SUPRAFLEX Cruz, SYNERGY
- Where
- Ireland
- Volunteers
- 1,550 people
- Sponsor
- National University of Ireland, Galway, Ireland
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Myocardial Infarction, Acute Coronary Syndrome
Identification of Risk Factors for Acute Coronary Events by OCT After STEMI and NSTEMI in Patients With Residual Non-flow Limiting Lesions
The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- PECTUS-obs (NCT03857971)
- Testing
- Coronary Optical Coherence tomography
- Where
- Netherlands
- Volunteers
- 438 people
- Sponsor
- Radboud University Medical Center
Disorder Related to Renal Transplantation
The Effects of Omega-3 Fatty Acids in Renal Transplantation
Omega-3 fatty acids are provided through dietary intake of fish and seafood. Several dietary supplements containing omega-3 fatty acids are also commercially available.
- Trial name
- ORENTRA (NCT01744067)
- Testing
- Omega-3 fatty acids
- Where
- 2 sites in Norway
- Volunteers
- 132 people
- Sponsor
- Oslo University Hospital
Psoriasis
Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis
Psoriasis has been associated with an increasing risk for atherosclerosis. The investigators investigated whether surrogate markers of subclinical atherosclerosis, vascular dysfunction and myocardial dysfunction are impaired in…
- Trial name
- NCT02144857
- Testing
- etanercept, ustekinumab, cyclosporine
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Athens
Transthyretin Cardiac Amyloidosis
Effect of Trimetazidine on Coronary Flow in Transthyretin Cardiac Amyloidosis
The goal of this clinical trial is to learn if trimetazidine can improve blood flow in the heart in adults with transthyretin cardiac amyloidosis (ATTR-CM).
- Trial name
- TACT-TTR (NCT07836699)
- Testing
- Trimetazidine
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Fábio Fernandes
Video-assisted Thoracic Surgery
Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function During One-lung Ventilation
The investigators used transesophageal echocardiography (TEE) to assess the change of pulmonary blood flow and bi-ventricular function during lung isolation.
- Trial name
- NCT02365311
- Testing
- transesophageal echocardiography(TEE)
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
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