Clinical trials: Cardiac Flow
Type 2 Diabetes, Microvascular Coronary Artery Disease
Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics with Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM)
The study design is a double blinded randomised control trial study that aims to conduct a randomised controlled trial of empagliflozin and determine if empagliflozin will improve myocardial blood flow in asymptomatic high risk…
- Trial name
- CATCH-EM (NCT04541797)
- Testing
- Empagliflozin 10 MG, Stress Cardiac Magnetic Resonance
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Chronic Heart Failure
Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study
The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures.
- Trial name
- HiFlow-Heart (NCT04471129)
- Testing
- HFO/O2C/NIV, NIV/O2C/HFO
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Cystic Fibrosis (CF), Cardiovascular (CV) Risk
Heart and Blood Vessels Health in People With Cystic Fibrosis
Cystic fibrosis (CF) is a disease that affects over 11,000 people in the UK. It is a genetic condition that affects many organs including the lungs, pancreas, kidneys and liver.
- Conditions
- Cystic Fibrosis (CF), Cardiovascular (CV) Risk, Flow-mediated Dilation Evaluation of the Brachial Artery, Pulse Wave Analysis
- Trial name
- CHi-CF (NCT07692594)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Coronary Artery Disease, Coronary Artery Stenosis
Nationwide Cohort Study of Antiplatelet Agents as Primary Prevention
There is no specific recommendation regarding pharmacologic treatment as primary prevention for patients with intermediate coronary artery stenosis whose revascularization was deferred based on negative fractional flow reserve…
- Trial name
- NHIS (NCT06281041)
- Testing
- Antiplatelet Agents
- Where
- South Korea
- Volunteers
- 4,657 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease
Effects of Guiding Catheter on FFR and NHPR for the Assessment of Coronary Artery Stenoses (Disengage@Rest)
The DISENGAGE@rest study is a prospective registry carried out at Federico II University of Naples with the aim to evaluate the influence of the guiding catheter engagement within the coronary ostium on both FFR and…
- Trial name
- Disengage@Rest (NCT04975425)
- Testing
- Fractional Flow Reserve
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Coronary Artery Disease
Relationship Between Coronary Angiography Findings and Fractional Flow Reserve After Balloon Angioplasty
The goal of this prospective observational study is to learn about in patients who need percutaneous coronary intervention for coronary artery disease.
- Trial name
- PROBE-FFR (NCT05716997)
- Where
- 2 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Heart Disease
Impact of Preoperative FFR on Arterial Bypass Graft Functionality
This study was designed to evaluate the correlation between pre-operative FFR and the functionality of arterial bypass grafts six months after coronary artery bypass grafting.
- Trial name
- IMPAG (NCT02527044)
- Testing
- Fractional Flow Reserve (FFR)
- Where
- 2 sites in Belgium, Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Congenital Heart Disease
International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease
The international multicenter registry aims to collect real-world data on clinical outcomes and evaluate the net clinical success of transcatheter microvascular plug (MVP)-based pulmonary flow restrictors (PFRs) in patients with…
- Trial name
- RESTRICT (NCT07791069)
- Testing
- Transcatheter pulmonary flow restriction
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Coronary Disease
International Post-PCI FFR Extended Registry
Percutaneous coronary intervention (PCI) is a standard treatment strategy for coronary artery disease (CAD). With the presence of myocardial ischemia, PCI reduces the risks of death, myocardial infarction (MI), and…
- Trial name
- NCT05672862
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 2,128 people
- Sponsor
- Bon-Kwon Koo
Aortic Valve Stenosis
A Registry to Evaluate the Direct Flow Medical Transcatheter Aortic Valve System
The purpose of this postmarket Registry is to assess the standard of care and clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System used in clinical routine according to the approved commercial…
- Trial name
- DISCOVER (NCT01845285)
- Testing
- Aortic Valve Replacement
- Where
- 2 sites in Germany, Italy
- Volunteers
- 1,000 people
- Sponsor
- Direct Flow Medical, Inc.
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Non-ST-segment Acute Coronary Syndrome
Intravascular Ultrasound-derived Assessment of Hemodynamically Negative Lesions in NSTEACS Patients
This is an observational and prospective cohort study to examine whether the addition of IVUS plaque morphological evaluation to FFR haemodynamic assessment of non-culprit lesions in NSTEACS patients will better predict MACEs.
- Trial name
- IMPACT-NSTEACS (NCT03641898)
- Testing
- FFR-guided PCI, Intravascular ultrasound
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tianjin Chest Hospital
Coronary Artery Disease
Post-Market Registry of the ACIST CPM System and Navvus Catheter in Clinical Practice
This registry will collect real-world clinical evidence on the performance, safety, and usability of the ACIST CPM System and NAVVUS Catheter when used in accordance with approved labeling in a European commercial setting.
- Trial name
- ADVANCE-EU (NCT02060682)
- Testing
- Navvus Catheter FFR
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Acist Medical Systems
Cardiogenic Shock, Acute Myocardial Infarction (AMI)
Routine Microaxial Heart Pump Support and Protocolized Pulmonary Artery Catheter Monitoring Versus Standard Care in Heart Attack-Related Cardiogenic Shock
The goal of this clinical trial is to learn which treatment strategies improve survival in adult patients with acute myocardial infarction complicated by cardiogenic shock (AMI-CS).
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction (AMI), Heart Failure, Acute
- Trial name
- DOUBLE-SHOCK (NCT07762560)
- Testing
- Microaxial flow pump (left ventricular assist device), Pulmonary artery catheter, Conventional hemodynamic monitoring
- Where
- Germany
- Volunteers
- 780 people
- Sponsor
- Leipzig Heart Science gGmbH
Coronary Artery Disease
The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent
PIONEER-IV is a prospective, single-blind (patient), randomized, 1:1, controlled, multi-center study comparing clinical outcomes between angiography-derived physiology guidance to LRDP and usual care in an all-comers patient…
- Trial name
- PIONEER-IV (NCT04923191)
- Testing
- Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care
- Where
- 19 sites in Belgium, Ireland and 3 more
- Volunteers
- 2,540 people
- Sponsor
- National University of Ireland, Galway, Ireland
Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI)
Remodeling of Distal Coronary Vessel in Chronic Total Occlusions: Prediction Based on Hemodynamic Coronary Parameters
Background Revascularization of a chronic total occlusion (CTO) has gained popularity last decade. After recanalization there is an acute gain in vessel diameter, as well as a late lumen gain distal to the stent as a result of…
- Conditions
- Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI), Fractional Flow Reserve, Quantitative Coronary Analysis
- Trial name
- CTO-VR (NCT06728384)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Musculoskeletal Pain, Musculoskeletal Pain Disorder
Exergaming Experience of Older People With Chronic Musculoskeletal Pain
Chronic musculoskeletal pain is debilitating and can lower the quality of life in older people. Therapeutic benefits have been reported from exergaming used as an intervention for rehabilitation or alternative to exercise.
- Trial name
- NCT04029285
- Testing
- Exergaming
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Teesside University
Cardiovascular Disease, Endothelial Dysfunction
Effect of Homocysteine-lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease
Endothelial dysfunction is an early marker of atherosclerosis and is found in patients (pts) with coronary (CAD) and peripheral artery disease (PAD).
- Trial name
- NCT00693589
- Testing
- folic acid, vitamin B12 and B6 and rosuvastatin
- Volunteers
- 36 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Heart Disease, Angina Pectoris
Physiology and Residual Ischemia After Percutaneous Coronary Intervention
Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Chest Pain, Coronary Artery Disease
- Trial name
- EASY-PRIPCI (NCT04494750)
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Laval University
High Frequency Oscillation, Volume Targeted Ventilation
Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications.
- Trial name
- NCT06719284
- Testing
- HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order, HFOV at the settings applied prior to the study
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College Hospital NHS Trust
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