Clinical trials: Cardiac Flow
Arterial Hypertension
Association Between Left Ventricular Deformation and Aerobic Exercise Capacity in Untreated Arterial Hypertension
Impaired myocardial deformation may determine cardiac diastolic dysfunction. The investigators will investigate the vascular determinants of myocardial deformation and twisting-untwisting and their interrelation with exercise…
- Trial name
- NCT02346695
- Where
- Greece
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Athens
Transthyretin Amyloid Cardiomyopathy, Aortic Stenosis
Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy
The goal of this prospective clinical study is to improve the diagnosis of Low-flow low-gradient aortic stenosis (LF/LG AS), in patients with co-existing wild-type transthyretin cardiac amyloidosis (ATTRwt).
- Trial name
- DobAttrAS (NCT06372301)
- Testing
- Dobutamine stress echocardiography
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steen Hvitfeldt Poulsen
Non-Obstructive Coronary Atherosclerosis
Effect of Mental Stress on Myocardial Perfusion in Women
Mental stress-induced myocardial ischemia(MSIMI) has been recognized a significant clinical problem. Evidence has shown that individuals with MSIMI have 2 to 2.5 times higher risk to develop a major averse cardiovascular events…
- Trial name
- MS in women (NCT03982901)
- Testing
- Mental Stress Test
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Coronary Heart Disease, Metabolic Syndrome
Coronary Flow Reserve to Assess Cardiovascular Inflammation (CIRT-CFR)
Coronary flow reserve (CFR, calculated as the ratio of hyperemic over rest myocardial blood flow) is emerging as a powerful quantitative prognostic imaging marker of clinical cardiovascular risk.
- Conditions
- Coronary Heart Disease, Metabolic Syndrome, Diabetes Mellitus
- Trial name
- CIRT-CFR (NCT02786134)
- Testing
- PET scan, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Stenosis
Fractional Flow Reserve (FFR) Versus Intravascular Ultrasound (IVUS) in Intermediate Coronary Artery Disease
This study is a prospective, randomized, multi-center, open label trial to compare the clinical outcomes and effectiveness of Intravascular ultrasound (IVUS) versus Fractional Flow Reserve (FFR) guided Percutaneous coronary…
- Trial name
- FAVOR (NCT01175863)
- Testing
- Grey scale intravascular ultrasound (Galaxy or Virtual histology-Intravascular Ultrasound), Pressure wire(Radi Medical Systems)
- Where
- 8 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Ajou University School of Medicine
Ischemic Heart Disease
Association Between IVUS and OCT Parameters and Invasive Physiologic Indices
1. to evaluate diagnostic accuracy and performance of IVUS and OCT-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices. 2.
- Trial name
- NCT03795714
- Testing
- IVUS or OCT and Invasive physiologic indices
- Where
- 2 sites in South Korea
- Volunteers
- 166 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Correlation Study of Imaging Data Acquired During CABG With Data Acquired in the Cath Lab
Visual assessment of a coronary artery narrowing (called stenosis) seen on angiography is conventionally used to infer how likely the stenosis will limit blood flow (called ischemia) under conditions of increased demand (e.g…
- Trial name
- PERSEUS (NCT02138305)
- Testing
- ComboMap XT Guidewire, 'SPY' NIRF During CABG
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- East Carolina University
Perioperative Myocardial Injury, Myocardial Injury After Non-Cardiac Surgery
Intrahepatic Blood Flow Occlusion and Cardiac Injury Risk in Partial Hepatectomy
The goal of this observational study is to examine whether intrahepatic blood flow occlusion strategies during partial hepatectomy are associated with postoperative cardiac injury in patients undergoing hepatectomy.
- Conditions
- Perioperative Myocardial Injury, Myocardial Injury After Non-Cardiac Surgery, Hypotension, Ischemia Reperfusion Injury
- Trial name
- NCT06753461
- Testing
- intrahepatic blood flow occlusion
- Volunteers
- 2,600 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Delirium
Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction.
- Trial name
- NCT02084394
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Johns Hopkins University
Fetal Growth Retardation
Fetal Heart Rate Variability and Fetal Growth Restriction
There is growing evidence in the field of fetal heart rate variability revealing the fetal neurological state. Furthermore, fetal heart rate variability has shown potential as fetal surveillance in fetal growth restriction.
- Trial name
- (FGR) (NCT04288037)
- Testing
- fetal heart rate variability
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Cardiac Surgery
Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery
This is a randomized double blind trial of the use of the use of colloids vs crystalloid solutions for resuscitation of patients after cardiac surgery.
- Trial name
- NCT00337805
- Testing
- Pentaspan
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Aortic Valve Stenosis
Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery
The goal of this study is to investigate the genetic and gender specific differences, in patients with low flow low gradient aortic stenosis and high flow high gradient aortic stenosis.
- Trial name
- SALVAGE (NCT05696145)
- Volunteers
- 170 people
- Sponsor
- Lisa Gundestrup
Chronic Coronary Syndrome
CTFFR and Prediction of Non-Significant CAD Lesions
In this prospective cohort study, 250 patients with suspected or known CAD and at least one intermediate coronary lesion (50-70% stenosis) who had a NiFFR value greater than 0.80 underwent coronary computed tomography angiography…
- Trial name
- NCT06979427
- Testing
- NIFFR
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Shiraz University of Medical Sciences
Ischemic Heart Disease
Myocardial Perfusion Imaging by 15O-H2O PET/CT
The trial will include 5000 patients with evident or suspected ischemic heart disease refered to Department of Nuclear Medicine \& PET Centre, Aarhus University Hospital, for perfusion imaging by 15O-H2O PET/CT scan of the heart…
- Trial name
- NCT04451551
- Where
- Denmark
- Volunteers
- 5,000 people
- Sponsor
- University of Aarhus
Coronary Artery Disease
The Evaluation of Fractional Flow Reserve and D SPECT for the Intervention of Chronic Total Occlusion
Coronary chronic total occlusions (CTOs) are defined as an occluded coronary vessel with TIMI defined as an occluded coronary vessel with TIMI (Thrombolysis in Myocardial Infarction) grade flow 0 and an estimated duration of at…
- Trial name
- NCT03803020
- Testing
- fractional flow reserve and SPECT detection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Stenosis, Angina Pectoris
Evaluation of the Correlation Between the Coronary Stenosis Degree With FFRCT and the Grade of Stable Angina Pectoris
Angina pectoris is the most common clinical manifestation of coronary heart disease（CHD）, which is the main feature of chest pain caused by transient myocardial ischemia.
- Trial name
- NCT02802046
- Testing
- Computed tomographic angiography of coronary artery
- Volunteers
- 20 people
- Sponsor
- Guiyang No.4 People's Hospital
Myocardial Infarction
Which One Should be Treated in the Setting of Acute ST Elevation Myocardial Infarction - Culprit Lesion or Culprit Vessel?
The current guidelines still recommend emergent PCI of the culprit lesion and state that primary PCI should be limited to the culprit vessel with the exception of cardiogenic shock and persistent ischaemia after PCI of the…
- Trial name
- NCT02356510
- Testing
- Primary PCI
- Volunteers
- 637 people
- Sponsor
- Samsun Education and Research Hospital
Hypoxemic Respiratory Failure
Asymmetrical HFNCO vs Standard HFNCO Post Cardiac Surgery Patients
High-flow oxygen therapy has been applied after extubation in cardiac surgery patients with a well-known successful efficacy. The current authors plan to conduct a prospective, randomized, controlled study of the Asymmetrical…
- Trial name
- NCT06521489
- Testing
- Asymmetrical High Flow Nasal Cannula Oxygenation, Conventional High Flow Nasal Cannula Oxygenation
- Where
- Greece
- Volunteers
- 63 people
- Sponsor
- National and Kapodistrian University of Athens
Cerebral Hypoxia
The Effects of Hypobaria vs Hypoxia on Cerebral Functions.
The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.
- Trial name
- Hypoxia (NCT03303118)
- Testing
- Hypoxia
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Fliegerärztliches Institut
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Verona Coronary Physiology Interventional Registry
The Verona Coronary Physiology Interventional Registry (VR-CP) is an observational study that collects information on patients with suspected coronary artery disease who underwent coronary angiography with a functional assessment…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Coronary Heart Disease (CHD)
- Trial name
- VR-CP (NCT07186582)
- Testing
- Coronary physiology assessment using Fractional Flow Reserve (FFR) as per standard of care and angiography-derived FFR
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
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