Clinical trials: Cardiac Health
Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension
COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
The pathophysiological processes involved in COVID-19 pneumonia are not fully understood. Specific alterations of the airways, lung parenchyma and pulmonary vascular tree could explain a severe ventilation/perfusion heterogeneity…
- Conditions
- Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension, Myopathy, Restrictive Lung Disease
- Trial name
- COVISQAR (NCT04881214)
- Testing
- Pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Acute Coronary Syndrome
Positive Psychology to Improve Healthy Behaviors After an Acute Coronary Syndrome
In this proof-of-concept study, the investigators will assess the ease and usefulness of a positive psychology program in patients with acute coronary syndrome and less-than-optimal adherence to health behaviors.
- Trial name
- PEACE II (NCT02004158)
- Testing
- Positive psychology intervention
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction
Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People
A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis.
- Trial name
- SingHEART (NCT02791152)
- Where
- Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Sexual Behavior, Conflict, Family
Heart to Heart: Testing a Sexual Health Training for Foster and Kinship Caregivers
Heart to Heart is a brief pregnancy prevention training program delivered to foster and kinship caregivers to prevent unintended pregnancy in foster youth.
- Conditions
- Sexual Behavior, Conflict, Family, Pregnancy Related, Sexually Transmitted Diseases
- Trial name
- NCT03331016
- Testing
- Heart to Heart Training
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Acute Coronary Syndrome/ Myocardial Infarction, Coronary Artery Disease
Enabling Patient-Reported Outcomes Through Innovative Care - ACS (EPIC-ACS)
This study evaluates the effectiveness of an innovative care approach that integrates face-to-face education, motivational counseling, and mobile health (mHealth) support delivered via the LINE application among Thai older adults…
- Trial name
- NCT07390006
- Testing
- Innovative Care Approach, Usual Post-Acute Coronary Syndrome Care
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Coronary Artery Disease, Physical Inactivity
A Behavioral Science-Enhanced PHysician-led Remote Group Exercise InTervention for Women With Coronary Artery Disease
Ischemic heart disease is the leading cause of death in the United States and worldwide (Nowbar et al., 2019). Exercise has been shown to be effective in preventing repeat heart attacks, hospitalizations and death among heart…
- Conditions
- Coronary Artery Disease, Physical Inactivity, Sedentary Behavior
- Trial name
- BE-PHIT (NCT05611333)
- Testing
- Physician-Led Remote Exercise Program Intervention
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Brigham and Women's Hospital
Chronic Heart Failure
CardioBBEAT - Randomized Controled Trial to Evaluate the Health Economic Impact of Remote Patient Monitoring
The primary endpoint is the incremental cost effectiveness ratio (ICER), defined as the combined clinical endpoint "days alive and not in hospital nor stationary care per days in study" and the change in total cost compared to…
- Trial name
- NCT02293252
- Testing
- Remote patient monitoring (Motiva)
- Where
- Germany
- Volunteers
- 621 people
- Sponsor
- Eckhard Nagel
Marfan Syndrome
Marfan Syndrome Moderate Exercise Pilot
Marfan syndrome (MFS) affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection.
- Trial name
- NCT04641325
- Testing
- Exercise Intervention Group
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Type 2 Diabetes Mellitus (T2DM)
Brain-Heart Axis in Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus (T2DM) is associated with chronic hyperglycemia and metabolic disturbances that affect not only glucose metabolism but also the central nervous system, autonomic nervous system, and cardiovascular…
- Trial name
- NCT07757308
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
STEMI - ST Elevation Myocardial Infarction, Stent Thrombosis
TISSARA Trial: Ticagrelor Intervention to Reduce Stent Thrombosis and Acute MI Risk
Stent thrombosis (ST) remains a critical complication following primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction (STEMI).
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Stent Thrombosis, Antiplatelet Agents
- Trial name
- TISSARA (NCT06667349)
- Testing
- Ticagrelor
- Where
- Pakistan
- Volunteers
- 1,727 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Coronary Heart Disease, Cardiac Rehabilitation
Reducing Risk in Cardiac Rehabilitation: Partners Together in Health (PaTH) Intervention Study
The objective of the proposed study, using an experimental, two-group (n = 30 couples in each group) repeated measures design, was to pilot test the effects of the PaTH Intervention versus a usual care group in improving the…
- Trial name
- PaTH (NCT00926848)
- Testing
- Partners Together in Health (PaTH) Intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cardiac Rehabilitation
The Heart Health After Cardiac Treatment Study
The goal of this study is to determine whether participation in a tailored cardiac rehabilitation program delivered in a safety net setting, compared to usual care referral to an outside cardiac rehabilitation program, results in…
- Trial name
- HEART-ACT (NCT07158515)
- Testing
- Tailored cardiac rehabilitation, Referral to an external cardiac rehabilitation program
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Cardiopulmonary Disease
Effects of Secondhand Smoke on Flight Attendant Health
This is a study on a population of flight attendants who were exposed to occupational secondhand tobacco smoke (SHS). This research will examine associations between flight attendant SHS exposure and development of respiratory…
- Trial name
- FAMRI (NCT01639235)
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy Related, Glucose, Low Blood
Interval Versus Continuous Exercise During Pregnancy
The objective of this randomized cross-over design was to investigate the fetal well-being and maternal glycemic response to an acute bout of aerobic high-intensity interval training (HIIT) and moderate-intensity continuous…
- Conditions
- Pregnancy Related, Glucose, Low Blood, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus, Fetal Blood Flow
- Trial name
- NCT05369247
- Testing
- High intensity Interval Training, Moderate Intensity Continuous Training
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Febrile Neutropenia, Endocarditis
Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections
The primary purpose is to improve and quicken the microbial diagnosis in severe infections, since only one third of the cases are documented by blood cultures and adequate anti-infective therapy in the 48 hours reduced mortality…
- Conditions
- Febrile Neutropenia, Endocarditis, Severe Sepsis
- Trial name
- EVAMICA (NCT00709358)
- Testing
- Detection of microbial DNA in blood by SeptiFast®, detection of microbial DNA in blood by blood culture
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Health Education
Heart Failure and Therapeutic Education
This study looks at whether a special program called the Heart Failure Therapeutic Education Unit (UTIC) helps reduce hospital stays for people with heart failure.
- Conditions
- Heart Failure, Health Education, Diet, Sodium-Restricted, Disease Management
- Trial name
- NCT07006350
- Where
- France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier de Gonesse
Congenital Heart Defects
Optimizing Health Among Children With Congenital Heart Defects
Quality of life and heart health are intimately connected to childhood physical activity participation (PAP). Physical activity is critical to childhood growth, development, learning, socialization, and quality of life and is an…
- Trial name
- NCT00974688
- Testing
- Information Intervention, Demonstration Intervention
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- The Hospital for Sick Children
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Body Weight, Lipids
CCRC: Understanding the Effects of Omega-3 Fatty Acids Versus Lignans in Flaxseed on Metabolic and Inflammatory Markers Leading to Diabetes and Cardiovascular Disease
The aim of this study is to compare the effects of flaxseed on atherogenic lipids, plasma inflammatory markers, and insulin sensitivity.
- Conditions
- Body Weight, Lipids, Blood Glucose, Insulin
- Trial name
- NCT00935922
- Testing
- Flaxseed
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Disease, Obesity
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
Background: Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders.
- Trial name
- NCT01927783
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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