Clinical trials: Cardiac Imaging
Heart Failure, Diastolic
Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04603404
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Healthy Volunteer, Coronary Arterial Disease
Ultralow Dose PET Imaging of 18F-flurpiridaz
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for known or suspected coronary artery disease (for detecting myocardial ischemia or infarction)…
- Conditions
- Healthy Volunteer, Coronary Arterial Disease, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT07284576
- Testing
- 18F-flurpiridaz
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Coronary Artery Disease (CAD), Myocardial Ischemia
A Study of XTR004 Radiotracer in Healthy Volunteers
XTR004 is a 18F-labeled myocardial perfusion positron emission tomography tracer use to measure myocardial perfusion and myocardial blood flow.
- Trial name
- NCT05195879
- Testing
- XTR004
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Heart Failure
A Study Evaluating Biomarkers in Participants With Heart Failure (MK-0000-344)
The aim of this 2-part study is to assess B-type natriuretic peptide (BNP) as well as other circulating and imaging biomarkers in myocardial function.
- Trial name
- NCT02364752
- Testing
- Blood Draw, Loop Diuretic Withdrawal/Salt Load
- Volunteers
- healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Heart Failure, Cardiometabolic Syndrome
Hyperpolarized MR Imaging with Carbon-13 Pyruvate in the Human Body
Positron emission tomography with 18F fluorodeoxyglucose (FDG) is the conventional imaging technique to provide information regarding tissue glucose uptake and has been highly clinically successful.
- Conditions
- Heart Failure, Cardiometabolic Syndrome, Cancer Diagnosis, Cardiovascular Diseases
- Trial name
- POLARIC-13 (NCT06645691)
- Testing
- Hyperpolarized 13C-pyruvate
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Fetal Anemia as Antepartum Condition (Diagnosis), Rh Incompatible Blood Transfusion Nos
Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion
INTRODUCTION Circulatory changes associated with fetal anemia have an important role in maintaining sufficient tissue oxygenation. With fetal anemia, hyperdynamic circulation and increased cardiac output occurred.
- Trial name
- NCT03169907
- Testing
- Mid trimesteric fetal ultrasonography
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Increased Right Ventricular Radiotracer Uptake
Stress Induced Right Ventricular Uptake on Lexiscan Stress MPI
The objectives of this study are to determine the: 1. Diagnostic value of stress induced RV changes on Lexiscan stress MPI as compared to Exercise stress MPI in predicting a significant CAD. 2.
- Trial name
- RVuptakeLexi (NCT01697995)
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Aiden Abidov
Fabry Disease
Study of the Relation Between Lipid Myocardial Overload Evaluated by Cardiac Magnetic Resonance Imaging (MRI), Alteration of Longitudinal Myocardial Deformations by Echocardiography, and Clinical Achievements (Functional, Biological and Electrical) in Fabry Disease, and Its Outcomes.
Anderson-Fabry disease is a genetic lysosomal storage disease, linked to chromosome X (gene GLA), responsible of enzyme synthesis deficit in α-galactosidase A with intracellular sphingolipids accumulation and multiorganic…
- Trial name
- FABRY-Image (NCT03123523)
- Testing
- Echocardiography at T0, Exercise test, Biological assays
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Myocardial Ischemia
Multi-modality Imaging of Ischemia With 18F-FDG PET and CTA
Coronary artery disease results in narrowing of the blood vessels supplying oxygenated blood to the heart muscle. Diagnosis in patients with symptoms of chest pain is now quickly done with CT coronary angiography.
- Trial name
- NCT01520025
- Testing
- PET MPI imaging with 18F-Fluorodeoxyglucose
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Heart Attack
Efficacy of Non Contrast DWI(Diffusion Weighted Imaging) Imaging Compared to DMR-DE
Use of MRI and DWI to diagnose cardiac scarring after heart attack.
- Trial name
- NCT01820000
- Testing
- Diffusion Weighted Imaging with MRI scans
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiovascular Disease, Healthy
Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy
Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation).
- Trial name
- NCT00001874
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging
The purpose of this study is to measure the changes in cardiac function during a Lexiscan pharmacologic stress test using cardiac magnetic resonance imaging test.
- Trial name
- NCT02115308
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Timothy M. Bateman
Physiological Changes in Deliberate Apnea
Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia.
- Trial name
- NCT02280226
- Testing
- magnetic resonance imaging (MRI)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Congenital Heart Disease, Fetal Cardiac Disorder
Fetal Cardiac Magnetic Resonance in Detection of CHD
The aim of this clinical prospective study is to investigate the value of fetal cardiac magnetic resonance imaging using a new Doppler ultrasound based gating method for the detection of congenital heart desease.
- Conditions
- Congenital Heart Disease, Fetal Cardiac Disorder, Heart Defect, Congenital
- Trial name
- NCT05066399
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Coronary Artery Disease
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care.
- Trial name
- CADOS-CMR (NCT02233634)
- Testing
- Oxygen, Hyperventilation Breath-hold (HVBH), HVBH with Oxygen
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Congenital Heart Disease With Systemic Right Ventricle
Study of Adaptation of the Right Ventricle to Systemic Afterload
the first purpose of the study is to determine the adaptative mechanisms of right ventricle (RV) to systemic afterload, and the mechanisms of RV failure, in patients with congenital heart disease and subaortic RV, using cardiac…
- Trial name
- STARS (NCT02066506)
- Testing
- asymptomatic group, symptomatic group
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, Dementia With Lewy Bodies
[18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DLB vs. AD
Study goal: The goal of this prospective head to head comparison is to evaluate the effectiveness of [18F]-MFBG PET in assessing cardiac innervation, comparing it with [123I]-MIBG SPECT The study's primary focus is on…
- Conditions
- Parkinson Disease, Dementia With Lewy Bodies, MSA - Multiple System Atrophy, Alzheimer Disease
- Trial name
- NCT06120049
- Testing
- [18F]-MFBG PET CT, [18F]-FE-PE2I PET CT or PET MRI, [123I]-MIBG SPECT CT
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Obstructive Coronary Artery Disease, Coronary Arteriosclerosis
Gadofosveset Trisodium for Heart Imaging Studies
Background: Magnetic resonance imaging (MRI) is type of imaging study that uses magnetic fields and radio waves to take pictures of the body. To help the images show up more clearly, a contrast agent is injected into a vein.
- Conditions
- Obstructive Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Artery Disease (CAD)
- Trial name
- NCT01853592
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)