Clinical trials: Cardiac Infection
Chagas Cardiomyopathy, Heart Failure
A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy
Chronic Chagas cardiomyopathy causes substantial morbidity and mortality in Latin America. Whether RAS inhibitors and beta-blockers are safe and beneficial has been challenged because of the lack of formal trials.
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT01557140
- Testing
- RASi plus carvedilol
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Minas Gerais
Heart Block, CIED Related Infection
Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation
Effect of single dose \& intrapocket prophylactic antibiotic to cardiac implantable electronic device-related infection \& biomarkers
- Conditions
- Heart Block, CIED Related Infection, CIED-related Infections, Antibiotic Prophylaxis
- Trial name
- BI-PACED (NCT06448624)
- Testing
- Ampicillin sulbactam 3 days
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Diponegoro
COVID-19, Coronary Artery Disease
Radiological Imaging in Patients Tested for COVID-19
It has become apparent that patients with co-morbidities have an increased risk of mortality from coronarvirus disease 2019 (COVID-19).
- Conditions
- COVID-19, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT05188443
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Septic Shock, Tachycardia
Effects of Heart Control at Different Stages in Patients of Septic Shock With Tachycardia
A sigle-center, randomized controlled trial will be do to investigate the effects of esomol on heart rate, clinical parameters, mortality, and safety in septic shock patients with tachycardia at different stages, compared with…
- Trial name
- NCT05389176
- Testing
- Esmolol
- Volunteers
- 96 people
- Sponsor
- Chinese Medical Association
Cardiac Implantable Electronic Device Infection
Cardiac Implantable Electronic Device Lifelong Antibiotic thErapy vs Stop and See
The goal of this non-randomized prospective study is to test whether 6-weeks antibiotic treatment can cure an cardiac implantable electronic device (CIED) infection in patients where device extraction is not feasible.
- Trial name
- CIEDLESS (NCT05958290)
- Testing
- Discontinuation of antibiotics
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hospital Readmission, Pneumonia
Mobile Integrated Healthcare and Community Paramedicine
Background: Initially conceived of as a method to address healthcare needs of underserved rural populations, Mobile Integrated Healthcare and Community Paramedicine (MIH/CP) is a new model of inter-professional, community-based…
- Conditions
- Hospital Readmission, Pneumonia, Myocardial Infarction, COPD
- Trial name
- NCT05061433
- Testing
- Mobile Integrated Healthcare/Community Paramedicine (MIH/CP) Support
- Volunteers
- 44 people
- Sponsor
- Rhode Island Hospital
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Covid19
Efficacy, Safety, and Immunogenicity of Vaccine Reimmunization With a Third Homologous Versus Heterologous Dose Against COVID-19 in Patients Undergoing Solid Organ Transplantation.
Patients undergoing solid organ transplantation randomly selected from those who have received two doses of Spikevax (Moderna) vaccine, provided that a minimum of 8 weeks have elapsed from the second dose to the time of the start…
- Trial name
- REIN-TX (NCT05048940)
- Testing
- Janssen vaccine, Spikevax (Moderna) vaccine
- Where
- Spain
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Rheumatic Heart Disease
Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection
The main goal of this project is to see if RADAR (Rapid AI-assisted Detection and Analysis of Rheumatic heart disease), which is a machine and deep-learning AI model, can help make rheumatic heart disease (RHD) screening easier…
- Trial name
- SHIELD 1 (NCT07599956)
- Testing
- AI assisted echocardiography
- Where
- Uganda
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Heart Rate Monitoring, Vagal Bradycardia
Heart Rate Variability and Early Cytokine Profile in Pediatric Adenotonsillectomy
This prospective observational cohort study will assess whether perioperative short-term heart rate variability (HRV) indices and early inflammatory cytokine levels are associated with respiratory and cardiac adverse events in…
- Conditions
- Heart Rate Monitoring, Vagal Bradycardia, Adenotonsillar Hypertrophy, Tonsillitis; Hypertrophic
- Trial name
- NCT07719439
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Duzce University
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Myocardial Injury, COVID-19
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination
The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination.
- Conditions
- Myocardial Injury, COVID-19, Vaccine Reaction
- Trial name
- MIDAVAX (NCT05359250)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Osteomyelitis; Vertebra, Endocarditis, Bacterial
T2MR PCR Detection of ESKAPE Pathogens in Patients With Pyogenic Spondylodiscitis and Infective Endocarditis
Our prospective observational study focuses on the rapid detection of etiologic agents of pyogenic spondylodiscitis and infective endocarditis using the T2 Bacteria Panel (T2Biosystems).
- Trial name
- NCT05644990
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
CIED-related Infections
Antimicrobial Strategy for Device Implantation
Infections associated with cardiovascular implantable electronic devices (CIEDs) represent one of the major postoperative complications in interventional cardiology.
- Trial name
- NCT07158502
- Testing
- TauroPace Cohort
- Volunteers
- 1,000 people
- Sponsor
- University of Calabria
Influenza, Human, Myocardial Injury
Cardiac Injury in Patients With Influenza
This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to…
- Trial name
- NCT03339180
- Where
- Sweden
- Volunteers
- 466 people
- Sponsor
- Örebro University, Sweden
Plasmodium Falciparum, Plasmodium Vivax
The Malaria Heart Disease Study
The Malaria Heart Disease Study is a prospective longitudinal cohort study of a random sample of approximately 1200 individuals from the state of Acre in Brazil.
- Conditions
- Plasmodium Falciparum, Plasmodium Vivax, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT04445103
- Testing
- Assessment of cardiac function
- Where
- Brazil
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hepatitis C, Heart Transplant
Expanding the Pool in Orthotopic Heart Transplantation
This is an open-label, pilot trial to test the safety and efficacy of transplantation of hearts from HCV seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on…
- Conditions
- Hepatitis C, Heart Transplant, Cardiac Transplant
- Trial name
- NCT03222531
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary E. Keebler, MD
Heart Failure
Persistent Cardiovascular Effects of COVID-19 Viral Infection Trial (PERCEIVE)
This is a prospective study in which a process of identifying and improving a reduction of functional capacity in COVID-19 survivors >50 years old.
- Trial name
- NCT04983823
- Testing
- Heart Failure intervention (Cardiac COVID Disease Management Plan (CC-DMP), Usual care
- Where
- Australia
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) - "HemodynamECMOnitoring-VA Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593756
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Cardiovascular Diseases, Coronary Disease
Inflammation, Infection, and Future Cardiovascular Risk
To examine markers of underlying chronic inflammation and infection as potential risk factors for future myocardial infarction (MI), stroke (CVA), and venous thromboembolism (VTE) in plasma samples collected at baseline from…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Myocardial Infarction
- Trial name
- NCT00005496
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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