Clinical trials: Cardiac Infection
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Sepsis, Heart Failure
Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels
Brain natriuretic peptide (BNP) is involved in the regulation of blood pressure and fluid volume. It is used for the early diagnosis of heart failure (HF) in patients presenting to the emergency room with dyspnea.
- Trial name
- NCT01382394
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rambam Health Care Campus
Infection, Heart Failure
Remote Physician Care for Home Hospital Patients
This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04080570
- Testing
- Remote Visit
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Brigham and Women's Hospital
Respiratory Tract Infections, Pneumonia, Bacterial
Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart Failure
Introduction: Acute Heart Failure is frequently decompensated by pulmonary infection, but the diagnosis of pulmonary infection sometimes is difficult in these patients due to similar signals and clinical symptoms in both…
- Conditions
- Respiratory Tract Infections, Pneumonia, Bacterial, Heart Failure
- Trial name
- EPICAD (NCT02787603)
- Testing
- Interruption of antibiotic treatment due to PCT measurement
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Surgical Wound Infection
Effects of Showering in 48-72 Hours of Median Sternotomy on Wound Infection, Pain, Comfort and Satisfaction
Time of showering after surgery is still a controversial issue for surgical patients and health professionals. It has been reported that patients should not shower until sutures are removed since traditionally showering is…
- Trial name
- NCT04250961
- Testing
- postoperative early shower
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Coronavirus, SARS-CoV-2
Hemodynamic Characteristics of Patients With SARS-CoV-2
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern.
- Conditions
- Coronavirus, SARS-CoV-2, COVID-19, Acute Respiratory Distress Syndrome
- Trial name
- PiCCOVID (NCT04337983)
- Testing
- Transpulmonary thermodilution, Echocardiography
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Bicetre Hospital
Heart Failure, Myocarditis
CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.
Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear.
- Conditions
- Heart Failure, Myocarditis, Sepsis, Septic Shock
- Trial name
- CONDUCT-ICU (NCT05633290)
- Testing
- CMR, hs-troponin, NT-pro BNP
- Where
- 2 sites in United Kingdom
- Volunteers
- 69 people
- Sponsor
- NHS Greater Glasgow and Clyde
Myopericarditis, Myocarditis
Myopericarditis After Messenger Ribonucleic Acid (mRNA) COVID-19 Vaccination in Children 5-11 Years Old
Myopericarditis is a rare complication to messenger ribonucleic acid (mRNA) COVID-19 vaccines, especially in male adolescents and young adults. The risk in children 5-11 years old is unknown.
- Conditions
- Myopericarditis, Myocarditis, Vaccination; Complications, COVID-19 Pandemic
- Trial name
- NCT05186571
- Testing
- Pfizer-BioNTech mRNA COVID-19 vaccination
- Where
- Denmark
- Volunteers
- 350,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Congestive Heart Failure, Exacerbation of COPD
The RAD-HOME Project: a Pilot Study of Domiciliary Teleradiology
Aim of the study is to assess feasibility and safety of a public territorial radiology service for home hospitalized frail elderly patients whose health conditions discourage the transportation to hospital.
- Conditions
- Acute Congestive Heart Failure, Exacerbation of COPD, Pneumonia, Fractures
- Trial name
- RHP (NCT01098916)
- Testing
- Home X-rays, X-rays in hospital
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Myocardial Infarction, Myocardial Injury
Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
Perioperative Myocardial Infarction (PMI) is a major contributor to perioperative mortality and morbidity with overall incidence of 5-16%.
- Conditions
- Myocardial Infarction, Myocardial Injury, Major Adverse Cardiac Events, Infectious Complications
- Trial name
- COPMAN (NCT04139655)
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Sponsor
- University of British Columbia
Circulatory Shock, Sepsis
Shock and Acute Conditions OutcOmes Platform
In-hospital mortality of patients admitted in the intensive care unit (ICU) for circulatory shock remains high (between 20 and 40%).
- Conditions
- Circulatory Shock, Sepsis, Cardiogenic Shock, Major Trauma
- Trial name
- ShockCO-OP (NCT06376318)
- Testing
- Inotrope, Mechanical circulatory support, anti-bodies
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Saint-Louis Hospital, Paris, France
HIV Infection, Coronary Heart Disease
High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIV
HILLCLIMBER is a randomized, controlled, open-label phase II trial of moderate dose statin therapy (pravastatin 40mg daily) versus high-dose statin therapy (rosuvastatin 20-40mg daily) in HIV-infected persons taking…
- Trial name
- HILLCLIMBER (NCT02841774)
- Testing
- Pravastatin, Rosuvastatin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Matthew Feinstein
Critical Illness
Evaluation of Patients With Critical Illness
This study provides training opportunities for critical care specialists in evaluating and treating critically ill patients. Patients enrolled in the study receive standard tests and treatments.
- Trial name
- NCT00100217
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiac Surgery Under Extra Corporeal Circulation
Immune Responses and Pulmonary Complications After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery under cardiopulmonary bypass (CPB) is associated with a high incidence of postoperative pulmonary complications (PPCs; 10% to 30% incidence).
- Trial name
- IIRIS (NCT07865533)
- Testing
- Blood sample collection, Bronchoalveolar lavage fluid collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19 Infection
Cardiac and Thoracic Imaging in Pediatric Patients With Evidence of Systemic Inflammation COVID19 Linked
To perform comprehensive cardiac and thoracic non invasive imaging assessment by MRI and/or CT scan including cardiac functional evaluation and myocardial tissue characterization of COVID_19 related disease in pediatric patients…
- Trial name
- CARDOVID (NCT04455347)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Imagine Institute
Heart Valve Diseases, Aortic Valve Stenosis
Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice
Valvular heart disease (VHD) is a growing public health concern globally, with increasing disease burden and rising interest in advanced treatment strategies such as transcatheter interventions.
- Conditions
- Heart Valve Diseases, Aortic Valve Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT07068633
- Where
- 2 sites in South Korea
- Volunteers
- 30,000 people
- Sponsor
- Yonsei University
HIV, Sexually Transmitted Diseases
Reducing HIV Risk Among Adolescents: Evaluating Project HEART
This study evaluates an educational web-based intervention designed to increase adolescent girls' motivation and skills to engage in safer sexual behavior (Project HEART: Health Education and Relationship Training).
- Trial name
- NCT02579135
- Testing
- Safer Sex, Growth Mindsets
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Cardiopulmonary Arrest, Fungal Infection
Pharmacokinetics/Pharmacodynamics (PK/PD) of Fluconazole in Children on Extracorporeal Membrane Oxygenation (ECMO)
Extracorporeal membrane oxygenation (ECMO) is a form of heart-lung bypass used to support children who suffer heart or lung failure until whatever illness caused that failure can be treated and reversed.
- Trial name
- NCT01169402
- Testing
- Fluconazole
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Michael Cohen-Wolkowiez
HIV Infection, Advanced End Stage Heart Failure
HIV+ Deceased Donor Heart Transplant Study for HIV+ Recipients
This will be a prospective single-center interventional trial to compare the outcomes of HIV-positive heart transplant recipients by the HIV status of the donor; HIV-positive vs.
- Trial name
- NCT06659952
- Testing
- HIV-positive heart transplant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Valvular Heart Disease, Rheumatic Heart Disease
Echocardiographic Screening of Pregnant Women During Antenatal Care
Non-obstetrical drivers of adverse pregnancy outcomes are underappreciated. Latent structural heart disease may account for a substantial proportion of adverse pregnancy outcomes in low-resource settings.
- Conditions
- Valvular Heart Disease, Rheumatic Heart Disease, Pregnancy Complications
- Trial name
- NCT04936815
- Testing
- Transthoracic echocardiography
- Where
- 2 sites in Nepal, Switzerland
- Volunteers
- 9,000 people
- Sponsor
- Thomas Pilgrim
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