Clinical trials: Cardiac Infection
Septic Shock
CO2 Gap Changes Versus Inferior Vena Cava Collapsibility in Relation to Cardiac Index as a Prognostic Value in Septic Shock
In 2016, sepsis and septic shock was redocumented as fatal organ dysfunction caused by infection-induced host response disorders (Singer et al. 2016).
- Trial name
- NCT06119815
- Testing
- CO2 GAP
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Cardiomyopathies
Myocardial Involvement of Severe Acute Respiratory Syndrome-Cov-2 (Covid19) Infected Patients
The effects of severe acute respiratory syndrome SARS-Cov-2 (Covid-19) on the myocardium and their role in the clinical course of infected patients are still unknown.
- Trial name
- COCARDE (NCT04358952)
- Testing
- Global Longitudinal Strain
- Where
- France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Toulouse
Acute Respiratory Infection, Sepsis
Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients
Capnodynamic monitoring has the potential to offer continuous and non-invasive measurements of heart and lung function in patients requiring ventilation in an intensive care setting.
- Conditions
- Acute Respiratory Infection, Sepsis, Postoperative Respiratory Distress
- Trial name
- PROFICIENT (NCT05082168)
- Testing
- Capnodynamic monitoring
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- South West Sydney Local Health District
Chronic Mental Illness, Chronic Physical Illness
Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project
The Wellness Incentives and Navigation (WIN) project is designed to help improve health self-management and reduce the incidence and consequences of chronic disease among non-elderly adult Medicaid Supplemental Security Income…
- Trial name
- WIN (NCT02440906)
- Testing
- Patient-Directed Wellness Account, Health Navigator
- Where
- United States
- Volunteers
- 1,663 people
- Sponsor
- University of Florida
Post-COVID-19 Syndrome
Transcutaneous Vagus Nerve Stimulation (tVNS) for Improved Recovery After Exertion.
Widespread infection with SARS-CoV-2 has resulted in millions of people having Post-COVID. Post-COVID is a complex, non-monolithic disease with diverse clinical manifestations.
- Trial name
- NCT06510985
- Testing
- transcutaneous vagus nerve stimulation, Monitoring, cardiowatch bracelet
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Respiratory Syncytial Virus Infections
A Study of Ziresovir (AK0529) in High-risk Adult With Respiratory Syncytial Virus (RSV) Infection.
Respiratory syncytial virus (RSV) is recognized worldwide as a significant pathogen causing lower respiratory tract infection in infants, the elderly, and immunocompromised patients, which may cause bronchiolitis or pneumonia…
- Trial name
- NCT07658534
- Testing
- Ziresovir (AK0529)
- Where
- 9 sites in China
- Volunteers
- 290 people
- Sponsor
- Shanghai Ark Biopharmaceutical Co., Ltd.
Postoperative Complications
The Effect of Telephone Nursing Education and Counseling Services Given to Satisfaction Level and Self-Care Strength
In the post-discharge period, it is important to follow the patients from home by telephone and to provide the necessary nursing education and counseling services, increasing the self-care powers of the patients, increasing their…
- Trial name
- NCT05487638
- Testing
- Nursing Education and Counseling Service Provided to Patients by Video Calling on the Phone
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Rheumatic Heart Disease, Heart Failure
Gliflozins on HF in Regurgitant Rheumatic Heart
The objective of this trial is to detect impact of Gliflozin on patients with heart failure due to reurgitant rheumatic valve disease
- Trial name
- NCT06097585
- Testing
- SGLT2 inhibitor
- Volunteers
- 150 people
- Sponsor
- Assiut University
Thoracic Surgery, Antibiotic Prophylaxis
Prevention of Infections in Cardiac Surgery
There is clinical equipoise about the question of whether antibiotic prophylaxis should be given for a short period or an extended period of time as reflected by inconsistencies in major guidelines, current practices at Canadian…
- Trial name
- PICS (NCT02285140)
- Testing
- Cefazolin, Vancomycin
- Where
- 4 sites in Canada
- Volunteers
- 5,989 people
- Sponsor
- Hamilton Health Sciences Corporation
Bacteremia, Infective Endocarditis
Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis
To evaluate the performance of a single high volume blood culture sampling strategy versus the actually used multiple sampling strategy for the diagnosis and categorization of infective endocarditis according to the Duke-Li…
- Trial name
- UniEndo (NCT03153384)
- Testing
- Blood Culture
- Where
- 8 sites in France
- Volunteers
- 269 people
- Sponsor
- Central Hospital, Nancy, France
Perinatal HIV Infection, Cardiac Fibrosis
Immune Correlates of Cardiac Structure and Function
The purpose of this study is to determine the occurrence of scarring of the heart (cardiac fibrosis) and inflammation in those with perinatally acquired Human Immunodeficiency Virus (HIV) infection compared to people not infected…
- Conditions
- Perinatal HIV Infection, Cardiac Fibrosis, Cardiac Inflammation
- Trial name
- NCT05328713
- Testing
- Cardiac MRI
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
COVID-19, Cardiopulmonary Disease
Comparing Inpatient COVID-19 Outcomes in 2 Different PT Dosing Groups
The objective of this study is to compare the effects of twice-a-day 15-minute sessions of inpatient physical therapy (PT) to the standard daily 30 minute sessions.
- Conditions
- COVID-19, Cardiopulmonary Disease, Weakness, Muscle, Hypoxia
- Trial name
- CCPT (NCT04844307)
- Testing
- Shorter duration higher frequency PT, Standard PT
- Sponsor
- Montefiore Medical Center
Sepsis
Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis
The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
- Trial name
- NCT06258252
- Testing
- Effect of BCAAs metabolic dysfunction on cardiac function in sepsis
- Volunteers
- 50 people
- Sponsor
- West China Hospital
HIV Infections, Coronary Artery Disease
Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons
The primary purpose of this study is to evaluate the association between nonalcoholic fatty liver disease (NAFLD) by computed tomography (CT) scan and coronary artery disease (CAD) measured by the calcium (CAC) score among…
- Conditions
- HIV Infections, Coronary Artery Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT00889577
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Shock, Death
Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units
Cardiac Intensive Care Units (CICUs) provide care for a diverse patient population. Understanding the clinical characteristics, analysis of treatment modalities, and prognosis of patients hospitalized in the CICU are important to…
- Conditions
- Shock, Death, Cardiac Intensive Care Unit, Treatment Complication
- Trial name
- POL-CICU (NCT06371677)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Heart Failure
Edge AI-deployed DIGItal Twins for PREDICTing Disease Progression and Need for Early Intervention in Infectious and Cardiovascular Diseases Beyond COVID-19 - Investigation of Biomarkers in Dermal Interstitial Fluid
The study will investigate, if inflammatory and cardio-circulatory biochemical biomarkers are detectable in dermal interstitial fluid (dISF) of heart failure patients, and if there are detectable kinetics of these biomarkers…
- Trial name
- NCT06200636
- Testing
- Use of the PELSA System for dISF extraction
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Covid19
Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19
Background: Respiratory and cardiovascular complications have emerged as dominant threats during and following coronavirus disease (COVID19) infection.
- Trial name
- NCT04887272
- Testing
- Supervised Exercise Training Protocol, Inspiratory Muscle and Exercise Training
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois Chicago
Infection
The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery
Antibiotics are routinely used to prevent surgical wound infection. Vancomycin is a widely used antibiotic for surgery in patients with an allergy to penicillin.
- Trial name
- NCT02051595
- Testing
- Vancomycin concentrations
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Sepsis, Septic Shock
Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response
Amiodarone is considered the medicine of choice in heart rate control in critically ill patients with atrial fibrillation with high ventricular response.
- Conditions
- Sepsis, Septic Shock, Atrial Fibrillation, Ventricular Fibrillation
- Trial name
- FAARV (NCT03715556)
- Testing
- Amiodarone, 0.9% physiological solution
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo General Hospital
Septic Shock
Effect of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg in Septic Shock Patients
A scientific research to prove the safety and effectiveness of TVS 0 - 4 mmHg as a target of resuscitation using furosemide, to improve Perfused Vessel Density (PVD) > 25 mm / mm2, AKI stage (based on KDIGO criteria), CI > 2.5 cc…
- Trial name
- NCT04156451
- Testing
- Fluid resuscitation and furosemide administration (bolus and continuous) with central venous pressure target 8 - 10 mmHg, Fluid deresuscitation and furosemide administration (bolus and continuous) with central venous pressure target 0 - 4 mmHg
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Indonesia
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