Clinical trials: Cardiac Inflammation
Heart Failure, Sudden Cardiac Death
Marathon, Genetics, Inflammation and the Cardiovascular System: MAGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with genotype/polymorphisms.
- Trial name
- MAGIC (NCT00845286)
- Testing
- Munich Marathon
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Myocarditis, Ventricular Arrythmia
GEAM Study Aims At Assessing the Role of Genetic Testing in Patients with Arrhythmic Myocarditis.
This study aims to answer multiple unsolved questions in the field of arrhythmic myocarditis. Improving the diagnostic work-up. While endomyocardial biopsy (EMB) and cardiac magnetic resonance (CMR) constitute the gold standard…
- Trial name
- GEAM (NCT06889662)
- Where
- Italy
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Oxidative Stress, Inflammatory Stress
Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
- Conditions
- Oxidative Stress, Inflammatory Stress, Myocardial Ischaemia
- Trial name
- NCT00311259
- Testing
- Melatonin (drug), Laktose
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Respiratory Tract Diseases, Cardiac Diseases
Cardiopulmonary Effects of Particulate Exposure
The aim of this study is to assess cardiac rate and respiratory responses and rhythm after workplace exposure to combustion particulates.
- Conditions
- Respiratory Tract Diseases, Cardiac Diseases, Bronchitis
- Trial name
- NCT00011310
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Arteriosclerosis, Myocardial Infarction
Alcohol, Inflammation and Atherosclerosis
Effect of moderate alcohol consumption in form of red wine, beer and ethanol solution and corresponding de-alcoholised beverages on immune measures.
- Trial name
- NCT00764426
- Testing
- red wine, beer, ethanol, de-alcoholised red wine, de-alcoholised beer, water
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- European Research Advisory Board
Coronary Heart Disease
Efficacy of Sterol Enhanced Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans
It is becoming increasingly clear that North Americans prefer dietary approaches to enhance health in favour of pharmaceutical approaches.
- Trial name
- NCT00924391
- Testing
- phytosterol enhanced soy based beverage, 1% milk
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Atrial Fibrillation, Sepsis
Continuous Ambulatory Cardiac Monitoring for Recurrent Atrial Fibrillation After Sepsis
To detect atrial fibrillation after infection.
- Conditions
- Atrial Fibrillation, Sepsis, Infections, Cardiac Arrhythmia
- Trial name
- CAMS-AF (NCT05217485)
- Testing
- Zio 14-day cardiac patch
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Systemic Inflammatory Response Syndrome
Conventional Ultrafiltration Versus Dilutional Ultrafiltration in Pediatric CPB Patients
The investigators will be comparing two different filtration methods on cardiopulmonary bypass for pediatric heart surgery patients.
- Trial name
- NCT07221630
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Fabry Disease, Cardiovascular Diseases
the Role of cArdiac Inflammation, endoThelial Dysfunction, and FIbrosis in fabrY Disease
The overall objective of this study is to investigate Fabry-related cardiomyopathy and the use of native T1-mapping, coronary microvascular function, cardiac inflammation, and cardiac injury in an effort to improve the ability to…
- Trial name
- RATIFY (NCT06776419)
- Testing
- Cardiac Magnetic Ressonance Imaging, 82Rubidium-positron emission tomography and computer-tomography
- Where
- Denmark
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Coronary Heart Disease
Safety and Efficacy of APL180 in Healthy Volunteers and Patients With Coronary Heart Disease (CHD)
The purpose of this study is to determine: (1) the safety and pharmacokinetics of APL180 administered as a single intravenous infusion in healthy volunteers, and (2) the safety, pharmacokinetics and pharmacodynamics of single and…
- Trial name
- NCT00568594
- Testing
- APL180
- Where
- 11 sites in United States, Belgium and 5 more
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Novartis
Periodontal Diseases
Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin
The premise of the relationship between the atherosclerotic process of coronary artery disease and periodontal disease is the immunoinflammatory process, which causes a significant increase in serum concentration of…
- Trial name
- NCT03753451
- Testing
- treatment of periodontal disease
- Where
- 2 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Heart Diseases, Diabetes
Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers
The purpose of this research study is to determine whether eating a fast food meal (high in saturated fat) will result in greater increases in inflammatory markers than eating a meal with low levels of saturated fat and higher…
- Conditions
- Heart Diseases, Diabetes, Obesity
- Trial name
- NCT00233311
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Coronary Arterial Disease (CAD)
The Effect of Cardiac Rehabilitation on Oxidative DNA Damage and Inflammation in Patients With Coronary Artery Disease
The objective of this study was to determine the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an indicator of oxidative stress, and to demonstrate oxidative DNA damage in cardiac rehabilitation treatment in patients with…
- Trial name
- NCT06867926
- Testing
- Cardiac rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Cardiovascular Diseases, Cardiovascular Risk Factor
Stratification Protocols and Clinical, Physical and Biochemical Parameters to Forecast Cardiovascular Intercurrences.
Introduction: Despite the various beneficial effects, cardiovascular rehabilitation programs (CVRP) have been associated with the appearance of signs and symptoms.
- Trial name
- NCT03446742
- Testing
- Cardiovascular rehabilitation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Coronary Artery Disease
Coronary Artery Disease: a Case- Control Study
Atherosclerosis is a chronic inflammatory condition, which is associated by the involvement of several pathological events, and alteration in the serum levels of pro- and anti-inflammatory, and lipid markers.
- Trial name
- NCT03075566
- Testing
- Healthy subjects, Patients
- Where
- Tunisia
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Nadia Bouzidi, PhD