Clinical trials: Cardiac Inflammation
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Severe
Reducing Elevated Heart Rate in Patients With Severe Sepsis by Ivabradine
REHSI is a prospective, multi-center, open label, randomized, controlled two arms, to evaluate the ability of ivabradine to reduce an elevated heart rate in septic shock patients.
- Trial name
- REHSI (NCT03367026)
- Testing
- Ivabradine Oral Product
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis Newborn
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery
- Trial name
- NCT03923543
- Testing
- Neutrophil to lymphosit ratio
- Volunteers
- 60 people
- Sponsor
- Firat Ergin
Septic Shock, Cardiac Output
Milrinone Versus Placebo in Patients With Septic Shock
Sepsis is one of the most serious healthcare problems, worldwide, and financial burdens. The overall mortality of severe sepsis/septic shock was 44.5-52.6%. A common cause of death is refractory shock and multi-organ failure.
- Trial name
- NCT05122884
- Testing
- Milrinone
- Where
- 2 sites in Thailand
- Volunteers
- 64 people
- Sponsor
- Mahidol University
Cardiomyopathies, Myocarditis
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
Two-parallel groups randomized, single-blinded, multi-center phase III controlled trial in patients with chronic inflammatory cardiomyopathy to assess the efficacy of colchicine and associated prospective registry to assess the…
- Conditions
- Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure
- Trial name
- CMP-MYTHiC (NCT06158698)
- Testing
- Colchicine
- Where
- 10 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Niguarda Hospital
Out-Of-Hospital Cardiac Arrest, Pneumonia
Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
Randomized-controlled trial and microbiome assessment to understand the risk-to-benefit ratio of prophylactic antibiotics (Ceftriaxone) vs placebo in patients with pneumonia and inflammation after cardiac arrest outside the…
- Trial name
- PROTECT (NCT04999592)
- Testing
- Standard of care without prophylaxis, Antibiotic prophylaxis
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- David J. Gagnon
Myocardial Inflammation
Outcome of Steroid Therapy for Myocardial Inflammation in Scleroderma
Primary myocardial involvement is common in scleroderma, effected to pericardium, vascular, conducting defect and especially myocardium.
- Trial name
- NCT03607071
- Testing
- Prednisolone and taper
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Khon Kaen University
Stroke, Ischemic, Inflammation
MR Evidence of Cardiac Inflammation Post-Stroke
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left…
- Conditions
- Stroke, Ischemic, Inflammation, Myocardial Injury
- Trial name
- MIRACLE (NCT05714618)
- Testing
- Gadolinium-enhanced cardiac MRI, B Natriuretic Peptide, Systemic inflammatory markers
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Luciano A. Sposato
Atherosclerotic Cardiovascular Disease, Heart Failure
Focus on Levels of Awareness and Perceptions Regarding hsCRP in Identifying Systemic Inflammation in ASCVD, CKD and Heart Failure Management
This is a survey-based study conducted among cardiologists and nephrologists treating people with Atherosclerotic Cardiovascular Disease (ASCVD), Heart Failure (HF) and Chronic Kidney Disease (CKD).
- Conditions
- Atherosclerotic Cardiovascular Disease, Heart Failure, Chronic Kidney Disease
- Trial name
- FLARE (NCT07160829)
- Testing
- No treatment given
- Where
- 4 sites in Australia, India and 2 more
- Volunteers
- 608 people
- Sponsor
- Novo Nordisk A/S
Coronary Artery Disease, Coronary Artery Stenosis
Efficacy and Safety of Comprehensive Treatment in Patients With IR-CAD: a Self-controlled Cohort Study
This is a self-controlled cohort study to evaluate the efficacy and safety of comprehensive treatment in patients with inflammation-associated rapidly-progressive coronary artery disease (IR-CAD) by comparing the study endpoints…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis, Coronary Artery Disease Progression
- Trial name
- NCT05860400
- Testing
- Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive therapy
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Peking Union Medical College Hospital
Cardiopulmonary Bypass, Cardiac Surgery
Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery
Cardiac surgery, especially when involving cardiopulmonary bypass (CPB), has long been associated with a systemic inflammatory response that can lead to a range of complications, from mild symptoms to severe organ dysfunction…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- OXYINFLAMM (NCT06993467)
- Where
- 2 sites in Italy
- Volunteers
- 908 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Coronary Artery Disease, Exercise
Effect of Long-term Exercise on Haemostasis and Inflammation in Patients With Coronary Artery Disease
Introduction: Regular exercise training improves prognosis in patients with coronary artery disease (CAD). This study investigates whether the beneficial effects of exercise can be partly explained by favourable changes in…
- Conditions
- Coronary Artery Disease, Exercise, Inflammation, Hemostasis
- Trial name
- NCT04268992
- Testing
- Long-term exercise
- Where
- Faroe Islands
- Volunteers
- 142 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Heart Failure With Preserved Ejection Fraction (HFPEF)
Colchicine in Patients With Heart Failure With Preserved Ejection Fraction and Inflammation
The main purpose of the CHIPS trial is to evaluate the efficacy and safety of colchicine in heart failure with preserved ejection fraction (HFpEF) patients with inflammation, including the effects of colchicine on circulating…
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction (HFPEF), Chronic Inflammation, Inflammation
- Trial name
- CHIPS (NCT06604611)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Dongying Zhang
ST-Elevation Myocardial Infarction
Brasilia Heart Study
BHS is a cohort study of consecutive myocardial infarction (MI) patients admitted within the first 24 hours of symptoms and has been ongoing since May of 2006.
- Trial name
- BHS (NCT02062554)
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- University of Campinas, Brazil
Cardiac Surgery, Inflammation
Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation
The purpose of this study is to see if ascorbic acid (Vitamin-C) therapy will reduce inflammation following heart surgery.
- Trial name
- AFIST (NCT00519337)
- Testing
- Ascorbic acid
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hartford Hospital
Stable Coronary Artery Disease Undergoing PCI
Rosuvastatin for Reduction of Myocardial Damage and Systemic Inflammation During Coronary Angioplasty
Myocardial necrosis is relatively frequent after percutaneous coronary intervention and is associated with higher mortality during the follow-up.
- Trial name
- REMEDY (NCT02205775)
- Testing
- Atorvastatin, Rosuvastatin, Ezetimibe
- Where
- 6 sites in Italy
- Volunteers
- 280 people
- Sponsor
- G. d'Annunzio University
Coronary Heart Disease, Metabolic Syndrome
Coronary Flow Reserve to Assess Cardiovascular Inflammation (CIRT-CFR)
Coronary flow reserve (CFR, calculated as the ratio of hyperemic over rest myocardial blood flow) is emerging as a powerful quantitative prognostic imaging marker of clinical cardiovascular risk.
- Conditions
- Coronary Heart Disease, Metabolic Syndrome, Diabetes Mellitus
- Trial name
- CIRT-CFR (NCT02786134)
- Testing
- PET scan, Echocardiogram
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Postoperative Cognitive Dysfunction
Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery
Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life.
- Trial name
- NCT07681063
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Heart Failure, Gastrointestinal Bleeding
Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD
This study evaluates the efficacy of high-dose fish oil in decreasing rates of gastrointestinal bleeding in patients with continuous-flow left ventricular assist devices.
- Trial name
- NCT03784963
- Testing
- Omega 3 fatty acids
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Multiple Organ Dysfunction
Modulation of Microbiota Metabolism in Cardiac Surgery Patients
An imbalance in the microbiota (most often intestinal) largely determines the onset of a disease state, and often a critical state.
- Trial name
- MMMMODCS (NCT04921436)
- Testing
- cardiac surgery
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Petrovsky National Research Centre of Surgery