Clinical trials: Cardiac Inflammation
Septic Shock, Left Ventricular Systolic Dysfunction
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
Septic shock is a major cause of death in intensive care. Septic shock is often dominated by profound changes in organ functions, of which cardiac failure is one of the most severe.
- Conditions
- Septic Shock, Left Ventricular Systolic Dysfunction, Left Ventricular Diastolic Dysfunction
- Trial name
- Septic Heart (NCT01747187)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Cardiovascular Diseases, Coronary Disease
Inflammation Markers Over Time in Cardiovascular Disease
To determine inflammation markers over time in cardiovascular disease. To test the hypothesis that measures of coagulation and fibrinolysis correlate with the incidence of coronary heart disease (CHD) and other thrombosis related…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Thrombosis
- Trial name
- NCT00005692
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Type 2, Coronary Artery Disease
Canagliflozin Targeting Vascular Inflammation
CANTOR SING is a pilot single center double blinded randomized study. The investigators will compare the effect of canagliflozin (300 mg daily - intervention arm) vs.
- Trial name
- CANTORSING (NCT05427084)
- Testing
- Canagliflozin
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Myocardial Infarction
Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.
The purpose of this study is to determine if intense control of high glucose levels in patients treated with angioplasty for heart attack has anti-inflammatory and anti-thrombotic effects.
- Trial name
- NCT00209144
- Testing
- Intensive insulin therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Acute Coronary Syndrome, Thrombosis
Hormones Inflammation and Thrombosis
The investigators are attempting to determine if the response to aspirin in women is related to the level of estrogen and progesterone that a woman has.
- Trial name
- HIT2 (NCT01875185)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Organ Dysfunction, Inflammation in Cardiac Surgery
Epigenetic Susceptibility to Inflammatory Complications After Cardiac Surgery
This study aims to better understand 3 crucial questions: 1. Why do some patients experience more severe complications after heart surgery than others? 2.
- Conditions
- Organ Dysfunction, Inflammation in Cardiac Surgery, Epigenetic, Coronary Artery Bypass Graft
- Trial name
- Epi-SICCS (NCT07865026)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Glasgow
Inflammation, Aortic Valve Stenosis
Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery
In this study, the investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and morbidity in patients who underwent aortic valve replacement due to aortic…
- Conditions
- Inflammation, Aortic Valve Stenosis, HDL
- Trial name
- NCT05641584
- Testing
- retrospective data review study
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Shock
Dopamine and Norepinephrine in Shock Patients
The purpose of this study is to compare the efficacy of dopamine and norepinephrine, two commonly used vasopressor agents, in the treatment of shock.
- Trial name
- NCT00314704
- Testing
- dopamine versus norepinephrine
- Where
- 8 sites in Austria, Belgium and 1 more
- Volunteers
- 1,679 people
- Sponsor
- Sepsis Occurrence in Acutely Ill Patients
Acute Kidney Injury, Cardiac Surgery
Prediction of Acute Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common and serious complication following cardiac surgery performed under cardiopulmonary bypass and is associated with increased morbidity, mortality, and prolonged hospital stay.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass Surgery, Cardiac Surgery Associated - Acute Kidney Injury
- Trial name
- AKI-CPB (NCT07343830)
- Where
- Turkey (Türkiye)
- Volunteers
- 455 people
- Sponsor
- Ataturk University
T2DM (Type 2 Diabetes Mellitus)
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Type II diabetes mellitus (T2DM) is a chronic disease associated with a very high risk of developing cardiovascular (CV) events, especially because of its long-term effects.
- Trial name
- STABLE-GLP1 (NCT07314684)
- Testing
- semaglutide, Standard Treatment (Guideline-Based)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Turner Syndrome
Is There a Link Between Inflammation and Endocrinopathies in Turner Syndrome?
Liver abnormalities are common in Turner syndrome. The physiopathology of these abnormalities is unknown for the moment but their potentially serious evolution requires additional explorations.
- Trial name
- NCT05473091
- Testing
- no intervention
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Central Hospital, Nancy, France
NSTEMI
COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients
Colchicine has antiinflammatory properties. It has been shown to be effective in improving outcome in stable coronary disease. The exact mechanism is unclear.
- Trial name
- CODEN (NCT02095522)
- Testing
- Colchicine
- Where
- 2 sites in Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Autonomic Nervous System Imbalance, Blood Pressure
Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
An intervention study to assess the short-term cardiovascular effects of reducing personal air pollution exposure by wearing particulate filtering respirators.
- Conditions
- Autonomic Nervous System Imbalance, Blood Pressure, Inflammation, Vasoconstriction
- Trial name
- NCT02238028
- Testing
- Wear respirator
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fudan University
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population
For patients with ACS undergoing PCI, intensive lipid-lowering including PCSK9 monoclonal antibody should be started as soon as possible, that is, lower LDL-C level should be achieved as soon as possible.
- Conditions
- Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, Lipid Lowering, Vascular Inflammation
- Trial name
- NCT06096909
- Testing
- Tafolecimab, Cholesterol Absorption Inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 3,684 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
The aim of REHAB trial is to investigate the impact of early mobilization after AMI in reducing left ventricular remodeling, as assessed by cardiac magnetic resonance imaging.
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, Systemic Inflammation, Ventricular Remodeling
- Trial name
- NCT04161378
- Testing
- Cardiac imaging, Laboratory analysis
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Atrial Fibrillation (Permanent), Atrial Fibrillation (AF)
Atrial Fibrillation: In Search for the Optimal Target for Rate Control
A rate control strategy is commonly adopted in the management of patients with Atrial Fibrillation (AF). Controversies remain as regards to what constitutes the optimal target of rate control.
- Trial name
- STRICT-4-FUN (NCT07135258)
- Testing
- Ivabradine + Usual Care
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Atherosclerosis, Coronary Disease
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation
This study will determine the effects of angiotensin-converting enzyme (ACE) inhibitor (trade name Ramipril) therapy on inflammation and stiffness of artery walls.
- Conditions
- Atherosclerosis, Coronary Disease, Vasculitis
- Trial name
- NCT00005928
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypovolemic Shock, Cardiogenic Shock
Renal Resistive Index in Patients With Shock
This study consists of two substudies. The first substudy: 'Renal resistive index in critically ill patients with cardiogenic and septic shock' Design: cross-sectional observational Aim of this project is: 1.
- Conditions
- Hypovolemic Shock, Cardiogenic Shock, Septic Shock, Kidney Failure, Acute
- Trial name
- NCT02558166
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Amsterdam UMC, location VUmc
Multiple Organ Dysfunction Syndrome
Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine
MODIfY is a prospective, single center, open label, randomized, controlled two arms, Phase II-trial to evaluate the ability of ivabradine to reduce an elevated heart rate in Multiple Organ Dysfunction Syndrome (MODS) patients.
- Trial name
- MODIfY (NCT01186783)
- Testing
- ivabradine
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg