Clinical trials: Cardiac Insufficiency
Post-Dural Puncture Headache, Hypotension
Different Approaches of Spinal Anesthesia in Patients Undergoing Cesarean Section
The goal of this clinical trial is to compare different approaches of spinal anesthesia in pregnant females who are having cesarean section.
- Conditions
- Post-Dural Puncture Headache, Hypotension, Spinal Shock, Hematoma
- Trial name
- NCT05637645
- Testing
- Midline Approach, Paramedian Approach, Taylors approach
- Where
- 4 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bahawal Victoria Hospital Bahawalpur
Heart Failure
A Study to Learn About the Taste of Vericiguat Given in Liquid Form in Healthy Male Participants Aged 18 to 45 Years
Heart failure is a condition in which the heart does not pump blood as well as it should. It can happen in both adults and children.
- Trial name
- NCT06474208
- Testing
- Formulation 1, Formulation 2, Formulation 3
- Where
- Germany
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bayer
Heart Failure With Preserved Ejection Fraction, Hypomagnesemia
Intracellular Magnesium and Heart Failure
Low magnesium levels are surprisingly common in those with a heart condition known as HFpEF, where the heart pumps well but is too rigid to fill properly with blood.
- Trial name
- NCT06353750
- Testing
- Magnesium supplement
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Heart Failure, Systolic, Heart Failure
A Multicenter Trial of a Shared DECision Support Intervention for Patients Offered Implantable Cardioverter-DEfibrillators
The investigators goal is to assess real-world effectiveness of patient decision aids (PtDA) for high-risk decisions using the implantable cardioverter-defibrillator (ICD) as a model.
- Trial name
- NCT03374891
- Testing
- Educational video and/or handout
- Where
- United States
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD
The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Ischemic Heart Disease
- Trial name
- NCT03780803
- Testing
- home cardiac rehabilitation and respiratory rehabilitation
- Where
- Poland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Heart Failure, Chronic Obstructive Pulmonary Disease
TeleHomecaRe InterVention Evaluation Study
The goal of this study is to evaluate the overall impact of Telehomecare on COPD and HF patients and system level outcomes using a comparison group of patients that did not participate in the program (for up to 18 months).
- Trial name
- THRIVE (NCT03212001)
- Where
- Canada
- Volunteers
- 5,400 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Heart Failure, Type 2 Diabetes Mellitus
Studies Investigating Co-morbidities Aggravating Heart Failure
SICA-HF is a prospective, multicentre, multinational, longitudinal, pathophysiological evaluation study, which is being conducted in 11 centres across six countries.
- Trial name
- SICA-HF (NCT01872299)
- Where
- 11 sites in Germany, Italy and 4 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
OSA, Heart Failure
Impact of Early Diagnosis and Treatment of OSA on Hospital Readmission in Hospitalized Cardiac Patients
The purpose of this study is to determine whether early diagnosis of obstructive sleep apnea and initiation of and adherence to CPAP therapy in hospitalized cardiac patients would impact 30-day hospital readmission rates.
- Conditions
- OSA, Heart Failure, Myocardial Infarction, Arrhythmia, Cardiac
- Trial name
- CV Readmit (NCT03647891)
- Testing
- Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Failure and Preserved Ejection Fraction, Obesity (Disorder)
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Obesity (Disorder), Heart Failure
- Trial name
- OBESE-HFpEF (NCT07539766)
- Where
- Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Heart Failure
Trial of an Interactive CD-Program on 6 Months Readmission Rate in Patients With Heart Failure
The purpose of this study is to determine whether extra education of patients with chronic heart failure can reduce 6 months readmission rate to hospital.
- Trial name
- NCT00311194
- Testing
- 6 months readmission rate to hospital
- Where
- Sweden
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Swedish Heart Lung Foundation
Heart Failure
A Trial of Thiamin Supplementation in Patients With Heart Failure
Background: Patients with heart failure (HF) are at increased risk of developing thiamin deficiency (TD). Thiamin (vitamin B1) is required for the production of energy and therefore TD may contribute to the energy depletion…
- Trial name
- NCT00959075
- Testing
- Vitamin B1
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Contrast Induced Nephropathy
Oral Versus Intravenous Hydration to Prevent Contrast Induced Nephropathy
The increased risk for contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) has been established.
- Trial name
- HYDRATE (NCT01093131)
- Testing
- Oral hydration, Oral sodium bicarbonate, Intravenous Hydration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Western Pennsylvania Hospital
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Acute Renal Failure, Acute Kidney Injury
Early Diagnosis of Postoperative Acute Renal Failure-using Biomarker to Predict Outcome of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this study is to determine soluble HJV could be an early diagnosis urinary biomarker of ischemia/reperfusion injury in post CPB-patients.
- Trial name
- NSARF (NCT01503710)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congestive Heart Failure (CHF)
CHF Management Using Telemedicine
The overall objective of this study is to improve clinical outcomes and quality of life for congestive heart failure (CHF) patients by integrating a readily available, low cost technology - the telephone - into coordinated CHF…
- Trial name
- NCT00309764
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Heart Failure, Chronic Kidney Diseases
Creating A Cardiorenal Multidisciplinary Team for Management HF and CKD Patients
Several drugs have been labeled as guideline-directed-medical therapies (GDMT) to improve overall health outcomes and slow the progression of disease in patients with heart failure (HF).
- Trial name
- NCT05531214
- Testing
- Multidisciplinary Care Coordination Team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- George Washington University
Heart Failure
SCREEN-HFI (SCReening Evaluation of the Evolution of New Heart Failure Intervention Study)
Individuals who were a part of the investigators Screen-HF study (NCT00400257) whose BNP level are in the top quintile will be offered participation in this study.
- Trial name
- NCT00604006
- Testing
- Spironolactone
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Monash University
Chronic Heart Failure
Renal Sympathetic Denervation for Patients With Chronic Heart Failure
To study whether renal sympathetic denervation(RSD) RSD can slow the progression of CHF and reduce the rate of all-cause mortality effectively and securely.
- Trial name
- RSD4CHF (NCT01790906)
- Testing
- RSD, Conventional therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Hypertension, Heart Failure
Frailty in Children With Cardiac Disease
Frailty is a complex biologic syndrome of diminished physiologic reserve that leads to decreased resistance to stressors and is associated with adverse health outcomes.
- Conditions
- Pulmonary Hypertension, Heart Failure, Single Ventricle
- Trial name
- NCT02999438
- Testing
- Actigraph to check activity levels at home
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City