Clinical trials: Cardiac Involvement
Transthyretin Amyloid Cardiomyopathy
Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM
This multicenter pilot study will enroll adult participants with a confirmed clinical diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) and heart failure (HF) controls with documentation within the past 2 years that…
- Trial name
- NCT07690436
- Where
- 20 sites in United States, Germany and 3 more
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Diastolic Dysfunction
Perioperative Measurements of Diastolic Function in Cardiac Surgery
This observational clinical trial will investigate the following perioperative indices relating to cardiac surgery: 1. The significance of measurements involving left heart relaxation (LV diastolic function) and its relation to…
- Trial name
- NCT02285309
- Testing
- Cardiac Surgery and enoximone
- Volunteers
- 100 people
- Sponsor
- University College, London
Persistant Atrial Fibrillation, Paroxysmal AF
The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on Atrial Mechancis Assessed by Cardiac Magnetic Resonance Imaging
Assessing the impact of a new atrial fibrillation (AF) catheter ablation energy on left atrial structure and function is of crucial importance.
- Trial name
- PF-MRI+ (NCT07499531)
- Testing
- Atrial fibrillation ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease, Heart Failure
Integration of Chronic Disease Rehabilitation Services Into Primary Care
The aim of PR1MaC is to establish a clinical intervention that will adapt and permanently integrate rehabilitation services into primary care settings, which would be the reference point in the health care system for people with…
- Conditions
- Cardiovascular Disease, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- PR1MaC (NCT01319656)
- Testing
- Support, management, educational, counselling, follow-up
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- Martin Fortin
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Covid19, Myocardial Injury
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or…
- Conditions
- Covid19, Myocardial Injury, Cardiovascular Diseases, Heart Failure
- Trial name
- CARDIO-COVID (NCT04624503)
- Where
- 5 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Humanitas Hospital, Italy
Atrioventricular Nodal Reentry Tachycardia, Supraventricular Tachycardia
Localization of Anatomical Structures Involved in Nodal Tachycardias by High Density Mapping.
The aim of the present work is to analyze the capacity of high resolution mapping systems to determine the precise location of the AV node and peri-nodal slow-conducting pathways, using standard recording parameters, but also…
- Trial name
- KOCH-MAPPING (NCT05296954)
- Testing
- high resolution cartography
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Tumor, Cardiovascular Diseases
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases
The purpose of this study is to conduct clinical research on [68Ga] Ga-NI-FAPI-04 PET/CT imaging and further investigate its diagnostic value in fibroblast activation related diseases.
- Conditions
- Tumor, Cardiovascular Diseases, Pulmonary Fibrosis, Rheumatic Immune Diseases Involving Large Blood Vessels
- Trial name
- NCT07464132
- Testing
- Injection of 68Ga-NI-FAPI
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
COVID, Sars-CoV2
Prospective Registry of Corona Virus Disease 2019 (Covid-19) Patients With Neuromuscular Involvement
Prospective registry for multimodal assessment of neuromuscular pathology associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, enrolling consecutive patients with corona virus disease 2019…
- Conditions
- COVID, Sars-CoV2, Corona Virus Infection, Myositis
- Trial name
- NCT04367350
- Testing
- laboratory biomarkers, muscle ultrasound
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer, Cardiac Toxicity
Side Effects Involving the Heart in Women With Breast Cancer Receiving Doxorubicin and Trastuzumab
RATIONALE: Studying samples of blood and tissue in the laboratory from women receiving doxorubicin and trastuzumab for breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers for…
- Conditions
- Breast Cancer, Cardiac Toxicity, Cardiovascular Complications
- Trial name
- PACE in BC (NCT00875238)
- Testing
- trastuzumab, doxorubicin hydrochloride, polymorphism analysis
- Where
- 4 sites in United States
- Volunteers
- 133 people
- Sponsor
- Vanderbilt University
Exercise Behavior, Multiple Myeloma
Exercise Phenotyping Prior to Chemotherapy in Newly Diagnosed Multiple Myeloma (MM-Exercise)
MM-Exercise is a prospective, single-centre, observational pilot study of patients with newly diagnosed multiple myeloma who have not yet started chemotherapy and whose resting echocardiogram is unremarkable or only mildly…
- Trial name
- MM-Exercise (NCT07851493)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technical University of Munich
Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Neurologic Evaluation
Neurologic Evaluation of Patients After Transapical Beating-Heart Septal Myectomy
The goal of this prospective cohort study is to evaluate the neurologic changes in patients that received transapical beating-heart septal myectomy.
- Conditions
- Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Neurologic Evaluation, Magnetic Resonance Imaging \(MRI\), Transapical Beating-Heart Septal Myectomy
- Trial name
- NCT06078410
- Testing
- Cardiac surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiang Wei
ST Elevation (STEMI) Myocardial Infarction
PICSO in Patients With STEMI Treated by Primary Percutaneous Coronary Intervention
A prospective multi-center study in which patients with an acute heart attack (in the left anterior descending artery) with ECG changes (ST segment elevation) receive angioplasty followed by stent placement and 90 minutes of…
- Trial name
- pRAMSES (NCT01493037)
- Testing
- PICSO (Pressure-controlled Intermittent Coronary Occlusion
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Miracor Medical SA
Transfer Anxiety, Intensive Care Unit Discharge
Nurse-Led Transfer Program With Family Involvement to Reduce ICU Patient Anxiety
This study aims to evaluate whether including a patient's family member during transfer from the intensive care unit (ICU) to the general ward can help reduce anxiety in patients who have undergone cardiovascular surgery.
- Conditions
- Transfer Anxiety, Intensive Care Unit Discharge, Cardiac Surgery Recovery, Postoperative Anxiety
- Trial name
- FICARE-TX (NCT06979414)
- Testing
- Nurse-led Transfer Programme with Family Involvement
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Yakup Akyüz
Pericarditis, Tako-TSUBO Cardiomyopathy
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
INFLAME-BANK is a French multicenter prospective observational ancillary study of the international EACVI-INFLAME project. It aims to establish a biobank and perform immunophenotyping and proteomic analyses in patients with…
- Conditions
- Pericarditis, Tako-TSUBO Cardiomyopathy, Myocarditis, Inflammatory Cardiomyopathies
- Trial name
- INFLAME-BANK (NCT07737470)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases
Subclinical Cardiac Involvement in Patients With Inflamatory Bowel Disease
Aim of the study is to determine the prevelance of subclinical cardiac involvement in patients with inflamatory bowel disease.
- Trial name
- NCT04330105
- Testing
- ECG, HolterECG ,Echocardiography
- Volunteers
- 200 people
- Sponsor
- Hossam Eldin Mohammed Essam Abdelhafez
Acute Coronary Syndrome
PLIN1 Variants in Precocious ACS (SCAPLIN)
This study aims to identify a genetic predisposition factor of precocious acute coronary syndrome occurrence (ACS). ACS is a major public health problem and the first cause of mortality in the world.
- Trial name
- NCT04904432
- Testing
- PLIN1 gene sequencing
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myocardial Injury, Non-cardiac Surgery
Hemodynamics and Myocardial Injury After Non-cardiac Surgery
The incidence of myocardial injury after non-cardiac surgery (MINS) is approximately 12-15% and is associated with an increased risk of 30-day mortality, 1-year mortality, and 2-year major vascular events.
- Conditions
- Myocardial Injury, Non-cardiac Surgery, Complication,Postoperative, High-sensitivity Troponin
- Trial name
- MINS (NCT05188001)
- Testing
- Not an Interventional Study
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiac Amyloidosis
Thalidomide/Dexamethasone Treatment And PET Evaluation In Organ Involvemenet of Cardiac Amyloidosis
To prove the organ-reversing potential of thalidomide for amyloidosis with cardiac involvement
- Trial name
- TaPiOCA (NCT02966522)
- Testing
- Thalidomide, Dexamethasone
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital