Clinical trials: Cardiac Magnetic Resonance
Acute Myocardial Infarction, Heart Failure
Peri-treatment of SGLT-2 Inhibitor on Myocardial Infarct Size and Remodeling Index in Patients With Acute Myocardial Infarction and High Risk of Heart Failure Undergoing Percutaneous Coronary Intervention
We aimed to identify whether SGLT-2 inhibitor administration before and after coronary intervention is effective in reducing the size of infarction and myocardial remodeling in patients with acute myocardial infarction (AMI) and…
- Trial name
- PRESTIGE-AMI (NCT04899479)
- Testing
- SGLT2 inhibitor, Control
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Persistent Atrial Fibrillation
The Substrate and Intervention Mechanisms for Persistent Atrial Fibrillation Trial
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with increasing morbidity and mortality. A catheter-based AF ablation technique that isolates pulmonary veins (PV) from the left atrium has been established…
- Trial name
- SIMPle-AF (NCT02918396)
- Testing
- Scar-Based Radio-frequency Ablation, Rotor Anchors Radio-frequency Ablation, Conventional PVI by Radio-frequency Ablation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Pulmonary Arterial Hypertension
A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magnetic Resonance Imaging
The purpose of the study is to assess the effects of selexipag on right ventricular (RV) function in participants with Pulmonary arterial hypertension (PAH).
- Trial name
- RESTORE (NCT04435782)
- Testing
- JNJ-67896049
- Where
- 35 sites in United States, Argentina and 13 more
- Volunteers
- 9 people
- Sponsor
- Actelion
Cardiac Disease, Covid19
Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT
The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular…
- Conditions
- Cardiac Disease, Covid19, Cardiotoxicity, Extracellular Space Alteration
- Trial name
- NCT04880317
- Testing
- Cardiac Magnetic Resonance, Additional CT acquisition, Blood tests
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Coronary Microvascular Dysfunction, Heart Failure With Preserved Ejection Fraction (HFpEF)
Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
The purpose of this study is to examine small vessel disease (a condition in which the small arteries in the heart become narrowed).
- Trial name
- NCT03876223
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Cedars-Sinai Medical Center
ST Elevation (STEMI) Myocardial Infarction of Other Sites
PREdisposition Genetical in Cardiac Insufficiency = Genetic Predisposition to Heart Failure
Our main goal is to create a prospective cohort of 1500 patients with a first large myocardial infarction allowing us, in a second step, to identify susceptibility genes for the progression of patients towards chronic heart…
- Trial name
- PREGICA (NCT01113268)
- Testing
- Cohort
- Where
- France
- Volunteers
- 658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Magnetic Resonance Angiography, Contrast Media
Improving the Concentration of MR Contrast in the Arteries
In Contrast-Enhanced Magnetic Resonance Angiography (CE-MRA) a contrast agent is injected into an arm vein using a programmable medical device called a power injector.
- Trial name
- NCT02155218
- Testing
- Standard Injection Rate, Patient Tailored Injection Rate, gadolinium contrast
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Heart Failure, Sarcopenia
The Sarcopenia Study
The goal of this cross-sectional study is to investigate the prevalence of sarcopenia in patients with Heart Failure. The main question it aims to answer is: Whether there is a difference in the prevalence of sarcopenia across…
- Conditions
- Heart Failure, Sarcopenia, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05888688
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Moderate Aortic Valve Stenosis
The Role of SGLT2i in Management of Moderate AS
Background: The aortic valve is like a door in the heart that lets blood flow out to the body. Over time, this valve can get worn out and become too narrow, leading to a condition called aortic stenosis.
- Trial name
- NCT06469645
- Testing
- Empagliflozin 10 MG
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- University of East Anglia
Coronary Artery Disease, ST Elevation Myocardial Infarction
Predicting the Risk of Non-culprit Coronary Artery Disease After a Heart Attack
Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time.
- Conditions
- Coronary Artery Disease, ST Elevation Myocardial Infarction, Ischemic Heart Disease
- Trial name
- OCT-RISK (NCT05781087)
- Testing
- Optical coherence tomography and pressure wire assessment, Cardiac magnetic resonance angiogram
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus
Background: Heart failure is a major cause of morbidity and mortality in diabetes mellitus, but its pathophysiology is poorly understood.
- Trial name
- PREDICT (NCT03132129)
- Testing
- Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring
- Where
- United Kingdom
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Heart Failure, Iron-deficiency
Changes in Myocardial Iron After Iron Administration
Recent studies have shown that treatment with intravenous iron in patients with iron deficiency (ID) and heart failure with reduced ejection fraction (HFrEF) improves symptomatology, functional capacity, quality of life, and…
- Trial name
- NCT03398681
- Testing
- Ferric carboymaltose, Cardiac magnetic resonance
- Where
- 6 sites in Spain
- Volunteers
- 53 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Non-ischemic Cardiomyopathy
Cardiac Magnetic Resonance for Risk Stratification in Non-dilated Left Ventricular Cardiomyopathy
Non-dilated left ventricular cardiomyopathy (NDLVC), a newly defined cardiomyopathy subtype characterized by non-ischemic myocardial abnormalities without left ventricular dilation, poses challenges in prognosis assessment and…
- Trial name
- NCT07351838
- Testing
- No intervention; Observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Left Ventricular Dysfunction
Phosphorous Magnetic Resonance Spectroscopy of Heart
Heart needs constant supply of energy to continue working. Phosphorus magnetic resonance spectroscopy allows us to measure energy produced in the heart.
- Trial name
- NCT01110395
- Testing
- MR Spectroscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Heart Diseases
Safety of Cardiac Pacemakers in 1.5T Tesla MRI
To evaluate short-term and long-term effects by MR imaging on the technical and functional status of Medtronic pacemakers.
- Trial name
- NCT00336011
- Testing
- Magnetic resonance imaging
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University Hospital, Bonn
Type 2 Diabetes, Microvascular Coronary Artery Disease
Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics with Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM)
The study design is a double blinded randomised control trial study that aims to conduct a randomised controlled trial of empagliflozin and determine if empagliflozin will improve myocardial blood flow in asymptomatic high risk…
- Trial name
- CATCH-EM (NCT04541797)
- Testing
- Empagliflozin 10 MG, Stress Cardiac Magnetic Resonance
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Cardiac Diseases
Comparison of Nexfin Pulse Contour Analysis and Cardiac Magnetic Resonance Imaging for the Measurement of Cardiac Output
A growing interest in monitoring cardiac output (CO) non-invasively has emerged, however its determination has been difficult using the standard approaches.
- Trial name
- NCT01639313
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- Universitätsmedizin Mannheim
Premature Ventricular Complex
Electrocardiographic and Cardiac Magnetic Resonance Predictors of Ventricular Arrhythmias in Cardiomyopathic Patients
This study aims to assess ECG changes for predicting ventricular arrhythmia in cardiomyopathic patients
- Trial name
- NCT05078125
- Testing
- Holter monitoring
- Volunteers
- 79 people
- Sponsor
- Assiut University
Myocardial Infarction
Characterization of Myocardial Infarction Scar Using Magnetic Resonance Imaging
The goal of this monocentric observationnal study is to describe the characteristics of the myocardial infarction scar in terms of transmurality in residual LVEF>35% patients.
- Trial name
- MI-SCAR-MRI (NCT05967026)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Heart Disease
Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2
CE-MARC 2 is a randomised controlled trial to determine diagnosis and patient management in patients presenting to outpatient clinics with suspected stable angina.
- Trial name
- CE-MARC2 (NCT01664858)
- Testing
- 3T CMR, SPECT, CT calcium score
- Where
- 6 sites in United Kingdom
- Volunteers
- 1,202 people
- Sponsor
- University of Leeds