Clinical trials: Cardiac Magnetic Resonance
Breast Cancer, Lymphoma, Large B-Cell, Diffuse
Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines
As the cancer-related prognosis improves thanks to recent advances in cancer-targeted therapies, the prognostic burden of chemotherapy-related complications - including cardiotoxicity - is increasingly recognised.
- Conditions
- Breast Cancer, Lymphoma, Large B-Cell, Diffuse, Cardiotoxicity, Left Ventricular Dysfunction
- Trial name
- CONTROL (NCT05728632)
- Testing
- Nebivolol
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Giulio Stefanini
Ventricular Ejection Fraction
DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function
The purpose of this clinical research study is to demonstrate the ability of Definity® enhanced versus unenhanced cardiac ultrasound to improve the accuracy and reproducibility of left ventricular ejection fraction (EF) when…
- Trial name
- NCT00401687
- Testing
- Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension
- Where
- 10 sites in United States
- Volunteers
- 131 people
- Sponsor
- Lantheus Medical Imaging
Myocardial Infarction, Percutaneous Coronary Intervention
China-Administration of Nicorandil Group（CHANGE）
We compared the infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) treated by nicorandil before and after the reperfusion with those standard…
- Conditions
- Myocardial Infarction, Percutaneous Coronary Intervention, Nicorandil
- Trial name
- NCT03445728
- Testing
- Nicorandil
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Infarction, Heart Failure
Sodium Thiosulfate to Preserve Cardiac Function in STEMI
Rationale: Timely and effective reperfusion by primary percutaneous coronary intervention (PPCI) is currently the most effective treatment of ST-segment elevation myocardial infarction (STEMI).
- Trial name
- GIPS-IV (NCT02899364)
- Testing
- Sodium thiosulfate, Sodium chloride 0.9%, primary percutaneous coronary intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen
Heart Diseases
Safety of Cardiac Pacemakers in 1.5T Tesla MRI
To evaluate short-term and long-term effects by MR imaging on the technical and functional status of Medtronic pacemakers.
- Trial name
- NCT00336011
- Testing
- Magnetic resonance imaging
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University Hospital, Bonn
Atherosclerosis, Chronic Granulomatous Disease (CGD)
Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System
Background: Atherosclerosis, the arterial plaques or blockages that cause heart disease, develops in many people by the time they are in their mid-20s.
- Trial name
- NCT01063309
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oncology, Cardiac Toxicity
Exercise Response After Revalidation in Cancer Patients
This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after…
- Trial name
- NCT04461392
- Testing
- Cardiorespiratory exercise test
- Where
- Belgium
- Volunteers
- 191 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cardiomyopathies, Amyloidosis Cardiac
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging…
- Conditions
- Cardiomyopathies, Amyloidosis Cardiac, Fabry Disease, Arrhythmogenic Cardiomyopathy
- Trial name
- CMPMIRNA (NCT06813443)
- Where
- 3 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiac Rehabilitation, Myocardial Fibrosis
Evaluate Aerobic Exercise on Myocardial Fibrosis and Intestinal Flora in Dilated Cardiomyopathy Diagnosed First Time.
To invegstive the Changes of Intestinal Flora and the improvements of Cardiac Fibrosis in Patients With Dilated Cardiomyopathy Diagnosed for the First Time by heart Rehabilitation
- Trial name
- NCT06039969
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing Medical University
Acute Myocarditis
Colchicine Versus Placebo in Acute Myocarditis Patients
Myocarditis is an inflammatory disease of the heart, mostly caused by viruses. Patients with acute myocarditis are exposed to several complications: recurrence, ventricular arrhythmias (from 5 to 30%), heart failure (5-10%)…
- Trial name
- ARGO (NCT05855746)
- Testing
- Colchicine Pill
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse
Mitro-annular Disjunction in Cardiac Magnetic Resonance
Mitral annular disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD is gaining clinical importance for several studies reporting its association to mitral valve prolapse (MVP), complex…
- Conditions
- Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse, Mitral Valve Disorder
- Trial name
- NCT06436573
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Acute Myocardial Infarction
The Effects of Facilitated Percutaeous Coronary Intervention in Acute Myocardial Infarction
The purpose of this study to investigate whether the administration of high-dose tirofiban before primary PCI could reduce myocardial infarct size, using analysis of contrast-enhanced magnetic resonance imaging.
- Trial name
- NCT00611169
- Testing
- tirofiban
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease
Myocardial Perfusion CMR for Differentiating and Characterizing Hypertrophic Cardiomyopathy Phenotypes
This observational study aims to evaluate myocardial perfusion abnormalities using quantitative and qualitative cardiac magnetic resonance (CMR) perfusion imaging in patients with hypertrophic cardiomyopathy (HCM) phenotypes…
- Conditions
- HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease, Cardiac Magnetic Resonance Imaging, Amyloid Cardiomyopathy
- Trial name
- MyoPerf-HCM (NCT07382128)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Atherosclerosis, Cardiovascular Diseases
Zhongshan Hospital Cardiovascular Imaging Registry
The purpose of this registry is to establish a multi-modality cardiac image database including coronary angiography (CAG), optical coherence tomography (OCT), intravascular ultrasound (IVUS), computed tomography angiograms (CTA)…
- Trial name
- NCT07080151
- Testing
- Cardiac imaging
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Muscular Dystrophy
Heart Imaging in Children With Muscular Dystrophy
Background: Muscular dystrophy can affect the muscles used for heart function and breathing. Treatment usually involves drugs that help improve heart function.
- Trial name
- NCT01633242
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocardial Infarction
Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction
To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.
- Trial name
- ICE-AMI (NCT07764588)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai 10th People's Hospital
STEMI
ExosoMe as Integrative Tool for pRognostic Stratification of Adverse Cardiac remodeLing in stEmi Patients: the MIRACLE Study
This is a multicenter observational prospective study aimed to assess whether plasma exosomes can help identify, at an early stage, patients at high risk of adverse remodeling after STEMI (ST-elevation myocardial infarction) …
- Trial name
- MIRACLE (NCT06070974)
- Testing
- CMR and blood collection
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Heart Failure, Diffuse Fibrosis
Using Cardiovascular Magnetic Resonance Tissue Characterisation and Wearable Technology to PREDICT Clinical Outcomes, Response to Therapy and Arrhythmias in Hospitalised Heart Failure Patients
150 patients admitted to University Hospital Southampton with heart failure will undergo comprehensive Cardiovascular Magnetic Resonance (CMR) imagining during their admission and continuous heart rhythm monitoring using wearable…
- Conditions
- Heart Failure, Diffuse Fibrosis, Focal Fibrosis, Arrythmia
- Trial name
- PREDICT-HF (NCT03689426)
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure (HF)
A Study on the Correlation Between Cardiac-Cerebral Oxygenation Reserve and Cognitive Function Changes in Heart Failure Patients
At different stages of heart failure (HF), the cardiac and cerebral oxygen reserve exhibits varying degrees of decline due to chronic hypoxia and microvascular dysfunction caused by reduced cardiac output, leading to cognitive…
- Trial name
- NCT07485816
- Testing
- breathing training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
ATTR-CM
Quantitative-imaging in Cardiac Transthyretin Amyloidosis
Transthyretin amyloid cardiomyopathy (ATTR-CM), is a heart muscle disease that's stops the heart muscle working properly. With an ageing population, it is increasingly common but untreated, it has a poor prognosis.
- Trial name
- I-CARE (NCT05776212)
- Testing
- 18F-fluoride PET
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University of Edinburgh