Clinical trials: Cardiac Output, active
Sepsis, Circulatory Instability
Ultrasound-Calibrated Pulse Contour Cardiac Output Monitoring: Value and Accuracy in Hemodynamic Care
This is a single-center prospective clinical study in the intensive care unit (ICU). Thirty adult patients with sepsis requiring hemodynamic monitoring and fluid resuscitation will be enrolled.
- Conditions
- Sepsis, Circulatory Instability, Hemodynamic Monitoring
- Trial name
- NCT07920237
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cardiac Output, Low, Coronary Arterial Disease
Post-Induction Low Cardiac Output Syndrome in Coronary Artery Bypass Graft Surgery
Hemodynamic change after induction of general anesthesia is usually judged from mean arterial pressure. Pressure, however, is a surrogate for flow, and the two can separate: cardiac output may fall while arterial pressure remains…
- Conditions
- Cardiac Output, Low, Coronary Arterial Disease, Anesthesia, General
- Trial name
- PiLCOs (NCT07810621)
- Testing
- routine clinical monitoring, observed only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Ataturk University
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Non-small Cell Lung Cancer, Cardiac Toxicity
Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment.
This study aimed to investigate the role of impedance cardiography (ICG) in evaluating hemodynamic changes during the 6-minute walk test (6MWT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who underwent…
- Trial name
- NCT06277388
- Testing
- Impedance cardiography
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Sun Yat-sen University
Low Cardiac Output Syndrome Bypass Children
Performance of Carbon Dioxide (CO2)-Derived Parameters in Predicting Low Cardiac Output Syndrome
In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction.
- Trial name
- GAP-CO2 (NCT07770386)
- Where
- France
- Volunteers
- 306 people
- Sponsor
- University Hospital, Lille
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypotension During Surgery
The Hypotension Prediction Index in Major Abdominal Surgery
The goal of this randomized clinical trial is to compare different types of advanced hemodynamic monitoring in patients undergoing major abdominal surgery.
- Trial name
- NCT06247384
- Testing
- Hypotension Prediction Index Hemodynamic Monitoring
- Where
- Poland
- Volunteers
- 226 people
- Sponsor
- Jakub Szrama
Vasovagal Syncope
Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments.
- Trial name
- Pacing_SV (NCT03446326)
- Testing
- Pacing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Perfusion Index and Cerebral NIRS Trends in Low Cardiac Output Syndrome
Can Perfusion Index and Cerebral Oxygen Saturation Trends Predict Low Cardiac Output in Pediatric Cardiovascular Surgeries
In this prospective, observational study, we aim to investigate whether routinely monitored Perfusion Index (PI) and cerebral oxygen saturation (NIRS) values in pediatric patients aged 0-6 undergoing congenital heart surgery are…
- Trial name
- NCT06759506
- Volunteers
- 40 people
- Sponsor
- Bozyaka Training and Research Hospital
Cardiogenic Shock
Correlation of Cardiac Output Determined by Echocardiography and Indirect Calorimetry in Critically Ill Patients in Cardiogenic Shock on Extracorporeal Circulatory Life Support
This observational study investigates whether the daily measured trend of cardiac output as evaluated by indirect calorimetry correlates with the same evaluated by transthoracic echocardiography.
- Trial name
- NCT06369818
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universität Münster
Anesthesia, Spinal, Hip Fractures
Haemodynamic Effects and Complications of Continuous Versus Single-shot Spinal Anaesthesia for HIP Fracture Surgery
This research project aims to identify a safer method of spinal anaesthesia for elderly patients undergoing surgical stabilisation of proximal femoral fractures.
- Trial name
- CHIPS (NCT07358299)
- Testing
- Bupivacaine Spinal 0,5% Heavy - bolus, Bupivacaine Spinal 0,5% Heavy - titration
- Where
- 2 sites in Poland
- Volunteers
- 216 people
- Sponsor
- Centre of Postgraduate Medical Education
Septic Shock
Assessment of Cardiac Output and Stroke Volume in Septic Shock Patients
The aim of this research is to compare the accuracy and reliability of electrical cardiometry versus transthoracic echocardiography in measuring cardiac output and stroke volume in patients with septic shock, to evaluate the…
- Trial name
- NCT07321405
- Testing
- echocardiogram, Electrical cardiometry
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Heart Failure Low Output
LBBP + CSP Versus LBBP Alone for Cardiac Resynchronization Therapy
The purpose of this pilot clinical trial is to evaluate whether a novel cardiac resynchronization strategy, called LOT-CRT, is more effective than standard physiological pacing alone (LBBAP) in patients with heart failure.
- Trial name
- LOTTO-CRT (NCT07664189)
- Testing
- Left Bundle Branch Optimized CRT, Stimulation of the left bundle branch area (LBBAP)
- Where
- Colombia
- Volunteers
- 10 people
- Sponsor
- Clinica Cardio VID
Necrotizing Fascitis, Cellulitis
Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
The central venous-arterial carbon dioxide tension difference is used daily in intensive care to establish peripheral tissue hypoperfusion, mainly mediated by a low cardiac index.
- Conditions
- Necrotizing Fascitis, Cellulitis, Septic Shock
- Trial name
- SEPTICO2HBO (NCT07492030)
- Testing
- Echography
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Heart Failure, Systolic
Paced Heart Rate Acceleration for Cardiac Conditioning
A clinical trial of exercise-similar heart rate acceleration delivered via cardiac pacing vs. sham intervention in subjects at rest will be performed.
- Trial name
- HeartExcel (NCT06332391)
- Testing
- Exercise-similar cardiac pacing
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Denice Hodgson-Zingman, MD
Pre-Eclampsia, Severe, Pregnancy
Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia
The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe…
- Trial name
- NCT07430254
- Testing
- Noninvasive finger plethysmographic cardiac output monitoring, Standard transthoracic echocardiographic assessment
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University
Anesthesia
Auxiliary Anesthesia Technique for Extracting Advanced Hemodynamic Parameters Based on Peripheral Arterial Waveform Photography
In this study, the arterial blood pressure waveform was digitized by snapshots or videos of the patient monitor to further estimate advanced hemodynamic parameters, so as to realize continuous and automatic monitoring of advanced…
- Trial name
- NCT05961358
- Testing
- snapshots or videos of monitor, Pressure transducer
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine