Clinical trials: Cardiac Resynchronization
Heart Failure (HF)
Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients
The primary objective of this study is to demonstrate that in patients with recuperated/normalized left ventricular function, defined as an ejection fraction (EF) ≥ 50%, after implantation of cardiac resynchronization therapy…
- Trial name
- STOP-CRT (NCT02200822)
- Testing
- beta blockers, RAAS blockers
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University
Heart Failure With Reduced Ejection Fraction
VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study
Heart failure affects over 1 million people in the United Kingdom. Approximately 50% have heart failure with reduced ejection fraction (HFrEF), a condition where the heart muscle does not contract properly.
- Trial name
- NCT06534151
- Testing
- CRT implantation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Congestive Heart Failure, Cardiac Resynchronization Therapy
TRIAGE-CRT Telemonitoring in Patients With CHF and Indication of CRT-D
This feasibility study will investigate the clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) and weight and blood pressure (BP) external telemonitoring (ETM) in the follow-up treatment of patients implanted…
- Trial name
- NCT00395642
- Testing
- Kronos LV-T, Lumax HF-T
- Where
- 12 sites in United States
- Volunteers
- 66 people
- Sponsor
- Biotronik, Inc.
Congestive Heart Failure
Device Evaluation of Contak Renewal 2and Easytrak 2 - DECREASE-HF
The purpose of this clinical investigation is to demonstrate the safety and effectiveness of the CONTAK® RENEWAL™ 2/4/4HE cardiac resynchronization therapy defibrillator (CRT-D) family and EASYTRAK® 2 lead in delivering LV-CRT or…
- Trial name
- NCT00158951
- Testing
- CONTAK RENEWAL 2/4/4HE CRT-D, EASYTRAK 2 Lead
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Arrhythmia
Comparison of Alcoholic Chlorhexidine 2% Versus Alcoholic Povidone Iodine for Infections Prevention With Cardiac Resynchronization Therapy Device Implantation
Heart Failure (HF) with systolic dysfunction is associated with a poor prognosis in the long term despite the use of many effective drug treatment in reducing morbidity and mortality.
- Trial name
- CHLOVIS (NCT01841242)
- Testing
- alcoholic povidone iodine, alcoholic chlorhexidine
- Where
- 24 sites in France
- Volunteers
- 2,272 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Arrhythmias, Cardiac, Atrioventricular Block
ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacing
The goal of this observational study is to evaluate the clinical characteristics of patients undergoing permanent cardiac pacing and to compare procedural efficacy and safety of different implantation approaches in the clinical…
- Conditions
- Arrhythmias, Cardiac, Atrioventricular Block, Reduced Systolic Function, Atrial Fibrillation
- Trial name
- TREEBEARD (NCT06324682)
- Testing
- Cardiac pacing - Conventional RV pacing, Cardiac pacing - Conduction System Pacing, Cardiac pacing - Cardiac resynchronization therapy (pacing - CRTP - or defibrillation - CRTD)
- Where
- 31 sites in Italy
- Volunteers
- 8,400 people
- Sponsor
- University Hospital of Ferrara
Heart Failure.
Latin America Cardiac Resynchronization Therapy Study
The Latin America CRT Study is a prospective, multicenter, interventional post-market release study conducted in Latin America. The geography includes Puerto Rico and the Caribbean, Mexico and Central America, and South America.
- Trial name
- LatAmCRT (NCT01238874)
- Testing
- Cardiac Resynchronization Therapy
- Where
- 2 sites in Mexico
- Volunteers
- 200 people
- Sponsor
- Medtronic Latin America
Heart Failure, Cardiac Resynchronisation Pacemakers
Optimisation of Cardiac Resynchronisation Therapy by Non-invasive Cardiac Output - The CHOICE2 Study
An evaluation of the role of resting and exercise cardiac output measurement, by the inert gas rebreathing method, in optimisation of patients with cardiac resynchronisation pacemakers.
- Trial name
- CHOICE2 (NCT01055210)
- Testing
- Optimisation of VV delay
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Dundee
Heart Failure
Investigation of Transvenous Versus Epicardial Left Ventricular Stimulation Technique
The purpose of this study is to demonstrate that epicardial and transvenous left ventricular leads are safe and effective for cardiac resynchronization therapy in heart failure patients implanted with a CRT device.
- Trial name
- INTREPID (NCT00819117)
- Testing
- Cardiac Resynchronization Therapy implant
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Left Bundle Branch Area Pacing
A Comparison of Left Bundle Branch Optimized Cardiac Resynchronization Therapy vs Left Bundle Branch Area Pacing Alone
Left bundle branch area pacing (LBBAP) has emerged as a promising physiological pacing strategy and may offer advantages over conventional biventricular pacing (BVP), including improved clinical outcomes.
- Conditions
- Heart Failure, Left Bundle Branch Area Pacing, Cardiac Resynchronization Therapy, Conduction System Pacing
- Trial name
- LOT or NOT (NCT07842874)
- Testing
- LOT-CRT-P (Programming: LBBAP), LOT-CRT-P (Programming: LOT-CRT-P)
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- PD Dr. Guram Imnadze
Heart Failure, Cardiac Resynchronization Therapy
THE RELATİONSHİP BETWEEN BLOOD GAS PARAMETERS OBTAİNED FROM THE CORONARY SİNUS DURİNG THE PROCEDURE AND CRT RESPONSE İN PATİENTS WİTH HEART FAİLURE WHO UNDERWENT CRT IMPLANTATİON
Heart failure (HF) is one of the clinical syndromes with the highest morbidity and mortality rates among cardiovascular diseases.
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Coronary Sinus
- Trial name
- NCT07436377
- Testing
- coronary sinus blood sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Trakya University
Heart Failure
OVATIO CRT and SITUS OTW LV Lead Post Approval Study
Post approval study measuring safety outcomes on the Ovatio CRT-D and SITUS OTW LV lead over 5 years.
- Trial name
- NCT00795873
- Where
- 33 sites in United States
- Volunteers
- 2,260 people
- Sponsor
- ELA Medical, Inc.
Atrioventricular Block, Conduction System Pacing
Impact of Atrioventricular Delay Optimization on Ventricular Function in Conduction System Pacing
Conduction system pacing has emerged as a physiological pacing strategy that preserves ventricular electrical activation and minimizes pacing-induced dyssynchrony.
- Trial name
- OPTI-CSP (NCT07624552)
- Testing
- Echocardiography-Guided Atrioventricular Delay Optimization
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Left Ventricular Dyssynchrony
Rest/Stress Quantification Of Left Ventricular Dyssynchrony By 3D Gated Blood Pool D-SPECT
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with advanced heart failure and left ventricular dyssynchrony (LVD). Too many patients do not clinically improve with CRT.
- Trial name
- NCT01390532
- Testing
- 3D Blood-Pool Gated SPECT (BPGS) with a new designed cardiac imaging camera (DSPECT, Spectrum Dynamics®, Ceasaria, Israel)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Failure, Cardiomyopathy
Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy
Cardiac resynchronisation therapy (CRT) has been documented to be a powerful treatment in patients with severe congestive heart failure. However, 30-40% of patients receiving a CRT are non-responders.
- Trial name
- CRID-CRT (NCT02525185)
- Testing
- Diagnostic interventions; PET, MRI, cardiac ultrasound.
- Where
- 2 sites in Belgium, Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Heart Failure
Comparison of Cardiac Resynchronisation Therapy (CRT) Response Using High Frequency (HF) - ECG or Q-LV Guided Optimisation for Left Ventricular, Pacing Site.
The research aims to compare the response of Cardiac Resynchronisation Therapy (CRT) using HF ECG guided or the conventional method of Q-LV measurement guided optimisation for left ventricular, pacing site.
- Trial name
- NCT05829876
- Testing
- High Frequency ECG Mapping, Q-LV Measurement
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University Hospital Birmingham
Heart Failure, Ischemic Cardiomyopathy
Optima Coronary Artery Disease (CAD) (Optimal Mechanical Evaluation)
To evaluate the impact of left ventricular (LV) lead location on LV mechanical function.
- Trial name
- NCT00896142
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Heart Failure
MultiPoint Pacing Programming Guided by Noninvasive Hemodynamics
The purpose of this study is to evaluate noninvasive hemodynamics with MultiPoint™ Pacing (MPP) and biventricular (BiV) pacing under various vector combinations and paced delays in patients receiving cardiac resynchronization…
- Trial name
- NCT02064751
- Testing
- CRT with MultiPoint Pacing, Hemodynamic measurements for CRT device programming
- Where
- 4 sites in Austria, France and 1 more
- Volunteers
- 40 people
- Sponsor
- Abbott Medical Devices
Ventricular Arrhythmia
Evaluating Ventricular Arrhythmia in Subjects With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-Defibrillator
The primary objective of this study is to evaluate the effect of eleclazine (GS-6615) compared to placebo on the overall occurrence of appropriate implantable cardioverter-defibrillator (ICD) interventions (antitachycardia pacing…
- Trial name
- TEMPO (NCT02104583)
- Testing
- Eleclazine
- Where
- 84 sites in United States, Canada and 7 more
- Volunteers
- 313 people
- Sponsor
- Gilead Sciences