Clinical trials: Cardiac Reverse Remodeling
Heart Failure With Decompensation
The Predictors and Benefits of Multi-discipline Disease Management Program in Heart Failure Patients
The investigator will investigate the predictors includes cardiac biomarkers, endothelial function and cardiopulmonary exercise test in prediction of cardiovascular outcome in patients with heart failure discharged from hospital.
- Trial name
- NCT03782337
- Testing
- multi-discipline disease management program
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- Chang Gung Memorial Hospital
Ppm, Cardiomyopathy
Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy
This randomized, controlled clinical trial investigates the potential cardioprotective effects of melatonin in women diagnosed with peripartum cardiomyopathy (PPCM).
- Trial name
- MEL-PPCM (NCT07334197)
- Testing
- Melatonin 10 MG, Selenium
- Volunteers
- 25 people
- Sponsor
- Tanta University
Dilated Cardiomyopathy, Ventricular Remodeling
The Impact of Ivabradine on Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy (NIDCM) on Current Medical Therapy Era
In non-ischemic dilated cardiomyopathy (NIDCM), left ventricular reverse remodeling (LVRR) can be achieved through guideline-directed medical therapy (GDMT).
- Conditions
- Dilated Cardiomyopathy, Ventricular Remodeling, Heart Failure, Reduced Ejection Fraction
- Trial name
- NCT05973591
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Yonsei University
Endomyocardial Fibrosis, Pulmonary Valve Stenosis
Right Ventricle Remodeling After Pulmonary Valve Replacement and Percutaneous Pulmonary Valve Insertion
This study investigates damage of the right cardiac chamber in adult patients with a congenital heart defect involving the pulmonary valve (the heart valve between the right cardiac chamber and the lungs).
- Conditions
- Endomyocardial Fibrosis, Pulmonary Valve Stenosis, Pulmonary Valve Insufficiency
- Trial name
- RV-REPAIR (NCT05090228)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- UMC Utrecht
Cardiac Failure
CRT Improved Clinical Response UK Trial
The main objective of the CRICKET study is demonstrate that AV and VV optimization using SonR improves LV reverse remodeling response to CRT, compared with 'Fixed Settings' (FS) after 6 months of treatment.
- Trial name
- CRICKET (NCT02669134)
- Testing
- Device programming
- Sponsor
- Aston University
Heart Failure, Dilated Cardiomyopathy
Harefield Recovery Protocol Study for Patients With Refractory Chronic Heart Failure
The purpose of this study is to evaluate whether patients with chronic heart failure not due to coronary artery disease who require use of a left ventricular assist device (LVAD) for refractory heart failure can recover…
- Trial name
- HARPS (NCT00585546)
- Testing
- clenbuterol
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Francis D. Pagani
Aortic Valve Regurgitation, Mitral Valve Regurgitation
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse…
- Conditions
- Aortic Valve Regurgitation, Mitral Valve Regurgitation, Left Ventricle Dilated, Left Atrium Dilated
- Trial name
- ORMIX (NCT06805253)
- Testing
- Not applicable - observational study
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Heart Failure, Left Ventricular Dysfunction
Microvascular Dysfunction Assessment to Predict Left Ventricular Reverse Remodeling
Patients presenting with idiopathic dilated cardiomyopathy and left ventricle dysfunction (LVEF <40%), naive of anti-remodeling cardiac medical therapy, will undergo invasive coronary microvascular assessment based on…
- Conditions
- Heart Failure, Left Ventricular Dysfunction, Idiopathic Dilated Cardiomyopathy
- Trial name
- MICROREV (NCT06356727)
- Testing
- Thermodilution based assessment of coronary microcirculation
- Where
- 12 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic
Pulse Reduction On Beta-blocker and Ivabradine Therapy
Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age.
- Conditions
- Dilated Cardiomyopathies, Idiopathic, Heart Failure, Systolic, Ventricular Remodeling, Electrical Remodeling
- Trial name
- PROBE-IT (NCT02973594)
- Testing
- Ivabradine
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Colorado, Denver
Heart Failure
REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00271154
- Testing
- Cardiac Resynchronization Therapy (CRT) Device or Implantable Cardioverter Defibrillator (ICD) with CRT
- Where
- 65 sites in United States, Austria and 13 more
- Volunteers
- 684 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Sleep Breathing Disorders in the Responders to Cardiac Resynchronisation Therapy (CRT)
Sleep Apnea, Arrhythmias and Cardiac Reverse Remodeling in Heart Failure Patients
Prospective, international, non-randomized, multicentre, clinical investigation (phase IV). The aim of the study is to investigate the correlation between HF, severe SBD, and AF in CRT-P patients at 6 months.
- Trial name
- SYNCHRO (NCT02870647)
- Testing
- Echocardiographic, polygraphy, electrocardiography measurements and sleep questionnaire
- Where
- 3 sites in Italy, Spain
- Sponsor
- LivaNova
Aortic Valve Stenosis, Aortic Stenosis
Left Ventricular Reverse Remodeling In Aortic Valve Replacement With Single Strip Pericardium Versus Mechanical Valve
Aortic stenosis is a commonly found heart disease, which often leads to mortality and morbidity. Valve replacement using mechanical prosthetic valve will have an expensive cost especially in the Integrated Heart Center of Cipto…
- Conditions
- Aortic Valve Stenosis, Aortic Stenosis, Valve Stenoses, Aortic, Aortic Valve Calcification
- Trial name
- NCT04056832
- Testing
- Single Strip Pericardium, Mechanical Prosthetic Valve
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Postpartum, Cardiometabolic Factors
Mediterranean Diet Intervention for Maternal Postpartum
The increasing prevalence of obesity during women's reproductive years highlights the need for effective strategies to improve nutritional literacy as a preventive approach to adverse postnatal outcomes.
- Conditions
- Postpartum, Cardiometabolic Factors, Cardiac Reverse Remodeling
- Trial name
- MedMom (NCT07038681)
- Testing
- Mediterranean Diet Intervention Group, Control Group (Standard Hospital Dietary Care)
- Where
- Portugal
- Volunteers
- 52 people
- Sponsor
- Universidade do Porto
Heart Failure
Monitoring of Hemodynamics in Heart Failure Patients by Intracardiac Impedance Measurement
Heart Failure (HF) is one of the most frequent diagnoses upon hospitalization and is a major cause of death. Cardiac resynchronization therapy (CRT) using an implantable device for synchronous bi-ventricular stimulation leads to…
- Trial name
- BIODetectHFII (NCT01711281)
- Testing
- Intracardiac Impedance Measurement Algorithm (integrated in CRT-D device)
- Where
- 22 sites in Denmark, Germany and 3 more
- Volunteers
- 68 people
- Sponsor
- Biotronik SE & Co. KG
Pulmonary Arterial Hypertension
A Study of Selexipag Assessing Right Ventricular Remodeling in Pulmonary Arterial Hypertension by Cardiac Magnetic Resonance Imaging
The purpose of the study is to assess the effects of selexipag on right ventricular (RV) function in participants with Pulmonary arterial hypertension (PAH).
- Trial name
- RESTORE (NCT04435782)
- Testing
- JNJ-67896049
- Where
- 35 sites in United States, Argentina and 13 more
- Volunteers
- 9 people
- Sponsor
- Actelion
Heart Failure
Effect of Intravenous FerRic carbOxymaltose oN Reverse Remodeling Following Cardiac Resynchronization Therapy
To assess impact on left ventricular reverse remodeling defined as a change in left ventricular ejection fraction in heart failure patients with reduced ejection fraction (and previous implantation of cardiac resynchronization…
- Trial name
- IRON-CRT (NCT03380520)
- Testing
- Ferric Carboxymaltose
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Hasselt University
Congenital Heart Disease, Pulmonary Valve Stenoses
Outcome of Balloon Pulmonary Valvuloplasty in Patients With Congenital Pulmonary Stenosis in Terms of Reverse Right Ventricular Remodelling and Functional Exercise Capacity
A prospective of 30 patients with symptomatic severe congenital valvular pulmonary stenosis who are indicated for percutaneous balloon pulmonary valvuloplasty . the aim is to 1.
- Trial name
- NCT05828524
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Heart Failure
Demonstration of Reverse Remodeling Effects of Entresto. Using Echocardiography Endocardial Surface Analysis
This study intends to measure the effects of valsartan/sacubitril compared to baseline standard medical heart failure therapy on reverse remodeling using echocardiographic endocardial surface analysis techniques to assess changes…
- Trial name
- NCT02754518
- Testing
- Entresto
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Chicago
Heart Failure With Preserved Ejection Fraction
Reverse Remodeling Effects of CDR132L in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Cardiac Hypertrophy
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study including approximately 130 randomized HF patients with heart failure with mildly reduced or preserved ejection fraction (LVEF ≥45%), to assess…
- Trial name
- REMOD-REVERT (NCT05953831)
- Testing
- CDR132L
- Sponsor
- Cardior Pharmaceuticals GmbH