Clinical trials: Cardiac Rhythm Disorders, open to volunteers
Atrial Fibrillation (AF)
Discontinuation of Anticoagulation With Intensive Rhythm Monitoring in Post-ablation Patients With Atrial Fibrillation
DIAMOND-AF is a multicenter, randomized, open-label trial evaluating whether discontinuing oral anticoagulation after successful atrial fibrillation ablation can reduce bleeding risk without increasing death or thromboembolism…
- Trial name
- DIAMOND-AF (NCT06871228)
- Testing
- NOAC discontinuation, NOAC continuation, Smartwatch single-lead ECG monitoring
- Where
- 22 sites in China
- Volunteers
- 4,100 people
- Sponsor
- Beijing Anzhen Hospital
Breast Cancer, Colon Cancer
Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer
The goal of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in 2 cohorts of patients.
- Trial name
- SRI-BrCa_CRC (NCT06281145)
- Testing
- Heart-rate variability biofeedback intervention
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- Comenius University
Atrial Fibrillation, Stroke
Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
A prospective, non-blinded, multi-center study to assess the impact of early Catheter Ablation (CA) in patients with a new diagnosis of Atrial Fibrillation(AF) at the time of stroke. 100 patients will be enrolled.
- Trial name
- SAVE STROKE II (NCT06783868)
- Testing
- Catheter Ablation, Market-approved AVNB, OAC and AAD
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Atrial Fibrillation, Atrial Fibrillation, Persistent
Electrical Cardioversion As a Predictor in Postoperative Preservation of Sinus Rhythm
The aim of this study is to evaluate benefits of electric cardioversion in the early and long-term postoperative period in patients after radiofrequency catheter isolation of pulmonary veins.
- Trial name
- NCT06654401
- Testing
- Transthoracic echocardiography, 24-hour ECG Monitor, Electroanatomic mapping
- Where
- Russia
- Volunteers
- 125 people
- Sponsor
- Saint Petersburg State University, Russia
Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal)
Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation
The goal of this study is to assess the short-term effects of minimal and moderate drinking on atrial fibrillation (AFib) episodes in a real-world population diagnosed with 'come-and-go'/paroxysmal AFib.
- Trial name
- FULL-PROOF (NCT06754176)
- Testing
- Alcohol Consumption Randomized Instructions
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Subclinical Atrial Fibrillation, Cardiac Arrhythmias
The Clinical Outcomes and Therapeutic Effects in Patients With Cardiac Implantable Electronic Device-detected Subclinical and Clinical Atrial Fibrillation.
Atrial high-rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are associated with an increased risk of progression to clinical atrial fibrillation (AF), stroke, heart failure, and mortality.
- Trial name
- AHRE (NCT07649109)
- Testing
- Early Rhythm Control Strategy, Usual Care
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation (AF), Hypertension (HTN)
Out-of-office Monitoring for Rhythms Of Normal Versus Atrial Fibrillation
The goal of this clinical trial is to learn if screening for atrial fibrillation (AFib), a common irregular heart rhythm, through daily home blood pressure monitoring will decrease the time to atrial fibrillation diagnosis in…
- Conditions
- Atrial Fibrillation (AF), Hypertension (HTN), High Blood Pressure
- Trial name
- OMRON-AF (NCT07582523)
- Testing
- Blood Pressure Monitor Without AFib Detection, Blood Pressure Monitor With AFib Detection
- Where
- United States
- Volunteers
- 1,910 people
- Sponsor
- University of California, San Francisco
Acute Ischemic Stroke, Atrial Fibrillation
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
- Trial name
- EAST-STROKE (NCT05293080)
- Testing
- Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation
- Where
- Germany
- Volunteers
- 1,746 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Major Depressive Disorder, Bipolar I Disorder
Digital Phenotypes for Predicting Depression_Validation
This 12-month, single-site prospective observational study will prospectively monitor the recurrence of mood episodes while continuously collecting passive digital phenotypes in individuals with and without mood disorders.
- Conditions
- Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders
- Trial name
- NCT07880015
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Atrial Fibrillation (AF)
Clinical Phase 2 Trial of AP31969 Versus Placebo for Rhythm Control of Atrial Fibrillation
A clinical Randomized Phase 2 Trial of AP31969 versus Placebo for Rhythm Control of Atrial Fibrillation.
- Trial name
- END-AF-1 (NCT07267949)
- Testing
- AP31969
- Where
- 46 sites in Bulgaria, Denmark and 6 more
- Volunteers
- 200 people
- Sponsor
- Acesion Pharma
Atrial Fibrillation (AF), Atrial Flutter
Detection of Atrial Fibrillation Through Voice Signal Processing
This study is testing a new technology that listens to a person's voice during short phone calls to help identify heart rhythm problems.
- Trial name
- NCT07212816
- Testing
- Sauti
- Volunteers
- 40 people
- Sponsor
- Vital Audio Inc
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Atrial Fibrillation (AF), Coronary Artery Disease
Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation
The goal of this clinical trial is to learn whether the antiarrhythmic drug flecainide can be used as safely as standard rhythm-control drugs in people with atrial fibrillation (AF) and stable coronary artery disease (CAD).
- Trial name
- ReCAST AF (NCT07405671)
- Testing
- flecainide, Sotalol or Amiodarone
- Where
- 14 sites in Belgium
- Volunteers
- 988 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
- Trial name
- HiRO-HCM (NCT05100420)
- Where
- 17 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Montreal Heart Institute
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation (AF), Coronary Artery Disease
OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation
The OPTIA-AF trial is a prospective, multicenter randomized controlled trial designed to evaluate a rhythm-guided antithrombotic strategy in patients with atrial fibrillation (AF) who maintain durable sinus rhythm after catheter…
- Conditions
- Atrial Fibrillation (AF), Coronary Artery Disease, Drug-eluting Stent
- Trial name
- OPTIA-AF (NCT07496281)
- Testing
- Oral anticoagulation, Single antiplatelet therapy
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Stroke, Ischemic, Sleep Disorder
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients.
- Trial name
- NCT05242393
- Testing
- No intervention is planned
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Heart Failure With Reduced Ejection Fraction, Heart Rhythm Disorder
Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
New onset heart failure (HF) is observed in up to 25% of patients with incident atrial fibrillation or flutter (AF). Current guidelines suggest that both conditions (AF \& HF) be addressed with guideline directed medical therapy…
- Trial name
- WEAN-HF (NCT06128980)
- Testing
- GDMT
- Where
- Denmark
- Volunteers
- 348 people
- Sponsor
- Herlev and Gentofte Hospital
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France