Clinical trials: Cardiac Rhythm Disturbance, open to volunteers
Ventricular Tachycardia (VT), Atrial Tachycardia
Clinical Study on the Efficiency of Rapid Arrhythmia Mapping Using EasyStars™ High Density Mapping Catheter Applications
The primary objective of this study was to evaluate the clinical feasibility, safety, and surgical characteristics of the EasyStars™ High Density Mapping Catheterin in patients with complex arrhythmias.
- Conditions
- Ventricular Tachycardia (VT), Atrial Tachycardia, Typical Atrial Flutter, Paroxysmal Atrial Fibrillation (PAF)
- Trial name
- Rapid Arrhythm (NCT07079813)
- Testing
- EasyStars™ High Density Mapping Catheter
- Volunteers
- 300 people
- Sponsor
- Shanghai MicroPort EP MedTech Co., Ltd.
Heart Failure and Reduced Ejection Fraction
Developing a Digital Aid to Improve ICD Decisions
Advanced heart failure, affecting 7 million Americans, has multiple causes and results in greatly increased risk of disability and death.
- Trial name
- NCT07084142
- Testing
- Online, patient-facing decision-making aid (app) with personalized risk information., Implantable Cardioverter Defibrillator (ICD), Online, patient-facing decision-making app without personalized risk information.
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Stanford University
Infant, Premature, Diseases, Premature Birth of Newborn
Elevated Midline Positioning During Diaper Change in Preterm Infants
Diaper changing is one of the most frequent routine care procedures in the neonatal intensive care unit (NICU) and is known to cause physiological instability and behavioral stress responses in preterm infants.
- Conditions
- Infant, Premature, Diseases, Premature Birth of Newborn, Pain
- Trial name
- NCT07865897
- Testing
- 30-Degree Elevated Midline Positioning, Standard Lateral Position Diaper Change
- Volunteers
- 80 people
- Sponsor
- Akdeniz University
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
Initial Double Sequential External Defibrillation in Out of Hospital Cardiac Arrest
Double Sequential External Defibrillation (DSED) represents an alternative treatment of refractory ventricular fibrillation (rVF) in out-of-hospital cardiac arrest (OHCA).
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
- Trial name
- DUALDEFIB (NCT06672159)
- Testing
- Two defibrillators, One defibrillator
- Where
- Norway
- Volunteers
- 356 people
- Sponsor
- St. Olavs Hospital
Right Bundle-Branch Block, Heart Failure
His-Bundle Corrective Pacing in Heart Failure
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs.
- Conditions
- Right Bundle-Branch Block, Heart Failure, His-bundle Pacing, Cardiac Resynchronization Therapy
- Trial name
- HIS-CRT (NCT05265520)
- Testing
- His-CRT implantation, BIV-CRT implantation
- Where
- 14 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Atrial Fibrillation (AF)
Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study
This is a single-arm, open label, clinical outcome study to research the durability (success) of receiving a pulsed field ablation (PFA) per standard of care for treatment of atrial fibrillation during a subsequent procedure for…
- Trial name
- PRECLUDE (NCT07620262)
- Testing
- Remapping Procedure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Atrial Fibrillation (AF), Atrial Flutter
Registry of Atrial Arrhythmia Ablation Procedures Using Pulsed Field Ablation in Poland
The aim of the described project is to establish a multicenter, nationwide registry of atrial arrhythmia ablation procedures using the Pulsed Field Ablation (PFA) method.
- Conditions
- Atrial Fibrillation (AF), Atrial Flutter, Atrial Tachycardia, Ablation Techniques
- Trial name
- PFA Registry (NCT07109141)
- Testing
- PFA ablation procedure of atrial arrythmia
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Wroclaw Medical University
Ventricular Tachycardia (VT)
Sympathetic Ablation for Ventricular Arrhythmias
Enrolled patients will undergo an acute procedure in which a catheter is inserted near the heart to ablate a sympathetic nerve, reducing signals that trigger ventricular arrhythmias.
- Trial name
- NCT07501819
- Testing
- Central sympathetic nerve ablation
- Volunteers
- 10 people
- Sponsor
- SymKardia
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
HFrEF - Heart Failure With Reduced Ejection Fraction, AF - Atrial Fibrillation
Wearable Device-Assisted Remote Management in Atrial Fibrillation Complicated by Heart Failure: WARM-HF Trial
Patients with acute decompensated heart failure (HF) have a significantly high risk of death and HF re-hospitalization during the vulnerable phase post discharge.
- Trial name
- WARM-HF (NCT07411170)
- Testing
- Wearable Device-Assisted Intervention
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital
Bradycardia, Atrioventricular Block
Procedural Endpoint in Left Bundle Branch Area Pacing: Conduction System Capture Versus LV Septal Capture
This is a prospective, multicenter, randomized controlled trial designed to determine whether direct capture of the left ventricular conduction system must be achieved as the procedural endpoint of left bundle branch area pacing…
- Conditions
- Bradycardia, Atrioventricular Block, Sick Sinus Syndrome, Cardiac Pacing
- Trial name
- COMPARE-SYNC (NCT07804394)
- Testing
- LBBAP with mandatory left ventricular conduction system capture (LBBP or LFP), LBBAP with left ventricular septal capture as the accepted procedural endpoint (LVSP)
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Ventricular Tachycardia
Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous…
- Conditions
- Atrial Fibrillation, Ventricular Tachycardia, Premature Ventricular Contraction
- Trial name
- NCT06575881
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation (AF)
Efficacy and Safety of Intravenous + Oral Vs. Oral Amiodarone in Preventing Recurrence After Catheter Ablation in Patients with Persistent Atrial Fibrillation
This study aims to investigate the efficacy and safety of intravenous combined with oral amiodarone in preventing atrial fibrillation (AF) recurrence after catheter ablation in patients with persistent atrial fibrillation.
- Trial name
- NCT06742866
- Testing
- Amiodarone Injection, Sodium Chloride Injection 0.9%
- Where
- China
- Volunteers
- 418 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Behavior
Mobile Health Technology-Enabled AFib Management
The overall objective of this proposal is to evaluate the effect on quality of life of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib…
- Trial name
- mTECH Afib (NCT06500988)
- Testing
- Corrie Virtual Atrial Fibrillation Management Program
- Where
- 2 sites in United States
- Volunteers
- 248 people
- Sponsor
- Johns Hopkins University
Intracerebral Hemorrhage, Atrial Fibrillation
Avoiding Anticoagulation After IntraCerebral Haemorrhage
Randomised controlled trials (RCTs) demonstrate a substantial benefit from oral anticoagulant drugs for the prevention of stroke and systemic embolism in non-valvular atrial fibrillation (AF).
- Conditions
- Intracerebral Hemorrhage, Atrial Fibrillation, Microhaemorrhage
- Trial name
- A3ICH (NCT03243175)
- Testing
- Apixaban 5 MG, left atrial appendage closure
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation
Pharmacological Intervention to Prevent NOAF After TAVR
The goal of this clinical trial is to learn if amiodarone or metoprolol works to prevent new-onset atrial fibrillation (AF) in patients who develop certain atrial arrhythmias after transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT07519161
- Testing
- Metoprolol succinate, Amiodarone
- Volunteers
- 198 people
- Sponsor
- Shanghai East Hospital
Atrial Fibrillation
Cohort Study for Atrial Fibrillation Risk Stratification
AFHRI is planned as a prospective, single-center cohort study in patients at high risk of AF.
- Trial name
- AFHRI (NCT05442970)
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Atrial Fibrillation (AF)
Alcohol as a Modifiable Risk Factor for Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, diagnosed in approximately 50 million people worldwide. Its prevalence is expected to increase, eventually affecting every third person, which will result in significant…
- Trial name
- AFFAIR (NCT07528729)
- Testing
- alcohol abstinence
- Volunteers
- 414 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrial Fibrillation Paroxysmal
RiLuzole to Reduce Atrial FIb Study Using Holter Monitoring
Atrial fibrillation (AF) is a growing clinical problem.1 AF is a highly dynamic condition involving episodes of sinus rhythm interspersed with periods of arrhythmia, becoming more difficult to terminate over time.
- Trial name
- SOLUTION (NCT05292209)
- Testing
- Riluzole 50 MG
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Utah
Paroxysmal Atrial Fibrillation
Catheter Ablation Using a Novel Navigation and Imaging System
The objective of the ENVIsIoN study is to collect data on the use of the VERAFEYE navigation and imaging system in patients indicated to undergo a catheter ablation procedure for the treatment of Paroxysmal Atrial Fibrillation…
- Trial name
- ENVIsIoN (NCT06895187)
- Testing
- VERAFEYE System
- Volunteers
- 100 people
- Sponsor
- LUMA Vision Ltd.
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