Clinical trials: Cardiac Surgery With Cardiopulmonary Bypass
Cardiac Surgery, Heart Surgery
Novel Venous Cannula Trial
This is a prospective, open-label, single-arm, single-center clinical investigation designed to evaluate the safety and performance of a Novel Venous Cannula during on-pump cardiac surgery requiring transfemoral venous…
- Conditions
- Cardiac Surgery, Heart Surgery, Cardiopulmonary Bypass, Minimally Invasive Surgical Procedures
- Trial name
- NCT07087639
- Testing
- Self-expanding Venous Cannula
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Eurosets S.r.l.
Cardiac Surgery Requiring Cardiopulmonary Bypass
Vancomycin Concentration Analysis in Post-Cardiac Surgery Patients
The benefits of antimicrobial prophylaxis for cardiac surgery have been clearly demonstrated in placebo-controlled studies. Prophylactic intravenous antibiotics are therefore administered, with agent selection directed against…
- Trial name
- NCT07087301
- Testing
- subtherapeutic concentration risk group
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Pengqiang Du
Cardiac Surgery, Cardiac Surgery Requiring Cardiopulmonary Bypass
Clinical Outcomes Between Pulsatile and Non-Pulsatile Flow During Cardiopulmonary Bypass
The aim of this prospective, randomized study was to compare clinical outcomes of Pulsatile and non-pulsatile flow during Cardiopulmonary Bypass.
- Trial name
- NCT07009730
- Testing
- Bypassing Agents
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Ultrasound, Pectoral Nerve Block
Ultrasound Guided Bilateral Pectoral Nerve Block Versus Bilateral Transverse Thoracic Plane Block In Pediatric Patients Undergoing Corrective Cardiac Surgeries Requiring Cardiopulmonary Bypass Via Median Sternotomy
This randomized, double-blinded, study aims to compare the efficacy of intraoperative and postoperative pain control while using bilateral ultrasound guided the pectoral nerves (PECS) versus transversus thoracic muscle plane…
- Conditions
- Ultrasound, Pectoral Nerve Block, Transverse Thoracic Plane Block, Pediatric Patients
- Trial name
- NCT06984276
- Testing
- Control, Pectoral nerves (PECS), Transversus thoracic muscle plane block (TTPB)
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Cardiac Surgery Requiring Cardiopulmonary Bypass, Extracorporeal Circulation
Biocompatible Versus Non-coated Extracorporeal Circuits in Cardiac Surgery
The aim of the present strudy is to investigate whether the use of biocompatible extracorporeal circulation circuits with a special hydrophilic polymer coating without heparin causes a reduction in the activation of the…
- Trial name
- BALANCE (NCT06612060)
- Testing
- Cardiac surgery with the use of extracorporeal circulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Polychronis Antonitsis
Cardiopulmonary Bypass, Cardiac Surgery
Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery
Cardiac surgery, especially when involving cardiopulmonary bypass (CPB), has long been associated with a systemic inflammatory response that can lead to a range of complications, from mild symptoms to severe organ dysfunction…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- OXYINFLAMM (NCT06993467)
- Where
- 2 sites in Italy
- Volunteers
- 908 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Insulin Resistance, Cardiac Surgery Requiring Cardiopulmonary Bypass
Relation Between Insulinoresistance and Neutrophile to Lymphocyte Ratio in Cardiac Surgery.
The University Hospital of Besançon is conducting a public interest research project called CRYSTAL, who studies the relationship between the Neutrophil to Lymphocyte ratio (NLR) and insulin resistance in post-operative cardiac…
- Conditions
- Insulin Resistance, Cardiac Surgery Requiring Cardiopulmonary Bypass, Neutrophil Lymphocyte Ratio
- Trial name
- CRYSTAL (NCT06945536)
- Where
- France
- Volunteers
- 211 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Cardiac Surgery Requiring Cardiopulmonary Bypass
Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study
The goal of this observational study is to determine the relationship of ROTEM point-of-care coagulation assay parameters with excessive bleeding and clinical outcomes in patients undergoing cardiac surgery at Toronto General…
- Trial name
- NCT06882759
- Testing
- No intervention (observational study)
- Volunteers
- 15,000 people
- Sponsor
- University Health Network, Toronto
Coagulopathy, Cardiopulmonary Bypass
Evaluation of TEG 6S PM® During Cardiopulmonary Bypass to Detect Postoperative Biological Coagulopathy
This is a prospective study to evaluate the predictive value of the TEG 6s platelet mapping® (TEG 6s® PM) performed during cardiopulmonary bypass (CPB) in the prediction of biological coagulopathy (determined by TEG 6S global…
- Conditions
- Coagulopathy, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PREDIPOC (NCT06230640)
- Testing
- In vitro medical diagnostic device TEG6s® Platelet Mapping
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Cardiac Surgery Under Extra Corporeal Circulation, Cardiac Surgery Requiring Cardiopulmonary Bypass
Comparison of the Performance and Effectiveness of Two Transfusion-Saving Devices: Cell-Saver and SAME
An observational study comparing two systems of perioperative blood recovery in cardiac surgery, one system allowing red blood cell reinfusion and one system allowing red blood cell and platelet reinfusion.
- Trial name
- SAME-CELL (NCT06766032)
- Testing
- CELL-Saver, SAME
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Nantes University Hospital
Cardiopulmonary Bypass, Cardiovascular Diseases
Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg.
- Conditions
- Cardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac Surgery
- Trial name
- PANDA (NCT06707350)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury
Increased Adsorption Membranes During Cardiopulmonary Bypass
Our project intends to reduce cardiac surgery associated - acute kidney injury (CSA-AKI) in non emergent patients with the use of an increased adsorption membrane (oXiris®) connected to the cardiopulmonary bypass (CPB) circuit…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury, Systemic Inflammatory Response Syndrome, Acute Kidney Injury
- Trial name
- NCT02518087
- Testing
- oXiris®
- Where
- 3 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari de Bellvitge
Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease
Transfusion in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB).
- Trial name
- TICVS (NCT06332547)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Guangdong Provincial People's Hospital
Surgery, Cardiac, Tranxemic Acid
The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Surgery, Cardiac, Tranxemic Acid, Activated Clotting Time, Heparin
- Trial name
- NCT06109155
- Testing
- Tranexamic acid
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- Taichung Veterans General Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction
Age is no longer an absolute contraindication to cardiac surgery therefore there is often need for combined interventions (double valve repair/replacement, or coronary artery bypass graft and valve repair/replacement) with…
- Trial name
- CRIDD (NCT04062396)
- Testing
- Eurosets REMOWELL 2 oxygenator, LivaNova INSPIRE oxygenator
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Maria Cecilia Hospital
Cardiac Surgery With Cardiopulmonary Bypass
Beta Blocker Use in Cardiac Surgery and Association With Postoperative Course
The objective of this study is to describe in a cohort of cardiac surgery patients the use of beta-blockers before surgery and their maintenance or withdraw according to international recommendations in order to compare patients…
- Trial name
- BLOCK (NCT04769752)
- Testing
- collection of the allocated treatment, collection of medical complications
- Where
- France
- Volunteers
- 1,789 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiopulmonary Bypass, Cardiac Surgery
Prediction of PPC Using DAMPs in Adult Cardiac Surgery
DAMPs (damage associated molecular patterns) are endogenous molecules that are expressed by cell stress or cell damage and play an important role in tissue (or host) defense and repair by activating the innate immune system.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Damage-associated Molecular Patterns
- Trial name
- NCT04945915
- Testing
- blood sampling
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Pusan National University Yangsan Hospital
Cardiac Surgery, Congenital Heart Disease
Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
Fibrinogen plays an important role in the coagulation cascade. Low levels of preoperative fibrinogen have been associated in adults with higher blood and transfusion requirements during surgery.
- Conditions
- Cardiac Surgery, Congenital Heart Disease, Cardiopulmonary Bypass, Fibrinogenemia
- Trial name
- NCT05525195
- Testing
- Congenital cardiac surgery
- Where
- Belgium
- Volunteers
- 932 people
- Sponsor
- Brugmann University Hospital