Clinical trials: Cardiac Surgical Procedures
Cardiac Surgery
The Influence of a Warmed Surgical Bandage System on Subcutaneous Tissue Oxygen Tension After Cardiac Surgery
Warmed Surgical Bandage may improve tissue oxygenation and thus on the long run reduce wound infections
- Trial name
- NCT00545506
- Testing
- conventional bandage, warming bandage
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Medical University of Vienna
Congenital Heart Defect, Surgery-Induced Tissue Adhesions
Effects of CoSeal on Bleeding & Adhesions in Pediatric Heart Surgery
This is a prospective, randomized, open-label, blinded-evaluator study that will evaluate the effectiveness of a surgical sealant (CoSeal) composed of biocompatible polyethylene glycol on the formation of mediastinal and…
- Conditions
- Congenital Heart Defect, Surgery-Induced Tissue Adhesions, Hemorrhage
- Trial name
- NCT01330433
- Testing
- CoSeal Surgical Spray Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Loma Linda University
Hyperglycemia
Sitagliptin in Non-Diabetic Patients Undergoing General Surgery
The purpose of this study is to compare sitagliptin with a placebo for the prevention of high glucose after general surgery.
- Trial name
- NCT02741687
- Testing
- Sitagliptin, Supplemental insulin (insulin lispro), Supplemental insulin (insulin aspart)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Elective Cardiac Surgery
CytoSorb® Reduction of FREee Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery
Prospective, multi-center, randomized, blinded, pivotal clinical study. Subjects will be randomized in a 1:1 ratio to either standard of care (SOC) alone or standard of care plus treatment with the CytoSorb® device.
- Trial name
- REFRESH II-AKI (NCT03384875)
- Testing
- CytoSorb
- Where
- 20 sites in United States
- Volunteers
- 186 people
- Sponsor
- CytoSorbents, Inc
Tetrology of Fallot, Heart Ventricle
Understanding Dexmedetomidine in Neonates After Open Heart Surgery
The purpose of this study is to determine what happens to dexmedetomidine in the body after it has been given to a newborn after heart surgery.
- Conditions
- Tetrology of Fallot, Heart Ventricle, Hypoplastic Left Heart
- Trial name
- Dex (NCT00576381)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Athena Zuppa
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease
CorMatrix ECM Study: To Identify Inflammatory Markers Following CABG With/Without ECM
The objective of this study is to identify proteomic inflammatory biomarkers to determine if there are differences in the biomarkers in patients who are treated using the CorMatrix ECM implant to close the pericardium and the…
- Trial name
- CorMatrix (NCT01535807)
- Testing
- CorMatrix extra cellular matrix (ECM)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Inova Health Care Services
Atrial Fibrillation
Atrial Deganglionation as a Therapy for Cardiac Surgery Patients With Atrial Fibrillation
A prospective single-arm study of ganglionated plexi ablation in cardiothoracic surgery patients with a history of atrial fibrillation.
- Trial name
- Neural-AF-2 (NCT05426759)
- Testing
- Pulsed Field Ablation of epicardial Ganglionated Plexi.
- Where
- Georgia
- Volunteers
- 12 people
- Sponsor
- Atrian Medical Ltd.
Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
Research indicates that hypothyroidism decreases heart contractility, reduces stroke volume and rate, affects the vascular endothelium, and increases the risk of atherosclerosis, systemic vascular resistance, hypertension…
- Conditions
- Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia, Euthyroid Sick Syndrome, Cardiac Surgery Requiring Cardiopulmonary Bypass
- Trial name
- L-Thyroxine (NCT06660823)
- Testing
- L-thyroxine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Open Heart Surgery
Closed Loop Isoflurane Administration With Bispectral Index in Open Heart Surgery
With the advancement in microprocessor technology and better understanding of pharmacodynamics and pharmacokinetics of anaesthetic agents, computer facilitated closed loop control of anaesthesia using propofol has been shown to…
- Trial name
- NCT01069562
- Testing
- Conventional control, Closed loop control
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Blood Transfusion, Cardiac Surgery
Red Cell Storage Duration and Outcomes in Cardiac Surgery
The purpose of this study is to determine whether length of storage of RBC is related to postoperative morbid outcomes in patients undergoing cardiac surgery.
- Trial name
- NCT00458783
- Testing
- Prolonged RBC storage, Short RBC storage
- Where
- United States
- Volunteers
- 3,942 people
- Sponsor
- The Cleveland Clinic
Cardiac Surgery
Remifentanil Versus Dexmedetomidine for Post-Cardiac Surgery Patients With Noninvasive Ventilation Intolerance
The aim of this study is to compare the sedation effects between remifentanil and dexmedetomidine in post-cardiac surgical patients who developed noninvasive ventilation (NIV) intolerance.
- Trial name
- REDNIVIN (NCT03395886)
- Testing
- Remifentanil, Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Surgery, Opioid Use, Unspecified
Pecto-Intercostal Fascial Plane Block Study
This study is being done to see if bilateral pecto-intercostal fascial plane blocks (PIFB) with a mixture of liposomal and standard bupivacaine decrease pain and opioid requirements in patients undergoing cardiac surgery via…
- Trial name
- NCT04928339
- Testing
- Bupivacaine Injection, Liposomal bupivacaine, Saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease
Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery
The purpose of this study is to compare sitagliptin and placebo for the prevention of high blood glucose during surgery.
- Trial name
- SITACABG NonDM (NCT02443402)
- Testing
- Sitagliptin, Regular Human Insulin, Insulin glargine
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emory University
Cardiac Disease
Combined Amiodarone and Electrical Cardioversion for Postoperative Atrial Fibrillation After Cardiac Surgery
To determine the efficacy of cardioversion and amiodarone for cardiac patients who develop postoperative atrial fibrillation
- Trial name
- NCT01558128
- Testing
- Amiodarone, Cardioversion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Weill Medical College of Cornell University
Atrial Fibrillation, Stroke
Minimally Invasive Surgical Treatment Versus Medical Management for Stroke Patients With Atrial Fibrillation
The purpose of this study is to compare a minimally invasive surgical procedure and medication management in stroke patients with Atrial Fibrillation.
- Trial name
- NCT01442181
- Testing
- Minimally Invasive Surgery, Medical therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Coronary Artery Disease
The MASS COMM Post-Randomization Phase Cohort Study
The primary objective of the Post-Randomization Phase Cohort Study is to continue to assess the safety of non-emergency PCI performed at hospitals without cardiac surgery on-site in patients with myocardial ischemia (other than…
- Trial name
- NCT02072421
- Testing
- PCI
- Where
- 10 sites in United States
- Volunteers
- 2,879 people
- Sponsor
- Baim Institute for Clinical Research
Morbid Obesity
McGrath Videolaryngoscopy and Direct Laryngoscopy in Morbidly Obese Patients
Our goal is to compare conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for endotracheal intubation in very morbidly obese patients undergoing non-cardiac surgery.
- Trial name
- NCT03467048
- Testing
- McGrath videolaryngoscopy, Direct laryngoscopy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Congenital Heart Disease, Inflammation
Ultrafiltration in Pediatric Cardiac Surgery: An Observational Cohort Study
Infants and children undergoing cardiac surgery with cardiopulmonary bypass (CPB) can experience systemic inflammation that prolongs post-operative recovery.
- Trial name
- NCT05154864
- Testing
- SBUF-SMUF
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre