Clinical trials: Cardiac Thrombus
Air Embolism, Neurological Damage
Insufflation of Carbon Dioxide During Cardiac Surgery as Prevention Neurologic Complications
Effect of intraoperative insufflation of carbon dioxide on the neurologic complications in the early postoperative period after open cardiac surgery.
- Trial name
- NCT02340741
- Testing
- conventional prophylaxis of aeroembolism, conventional prophylaxis plus CO2 insufflation, cardiac surgery with opening of heart chambers
- Where
- Russia
- Volunteers
- 334 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Arrhythmia, Atrial Fibrillation
Arterial Embolism After Catheter Ablation of Atrial Fibrillation. ATRIAL FIBRILLATION
The EMBOL-AF is a multicenter, international, observational study designed as a retrospective registry that will investigate the characteristics of systemic arterial embolic events after treatment of atrial fibrillation by…
- Conditions
- Arrhythmia, Atrial Fibrillation, Ablation, Stroke, Acute
- Trial name
- EMBOL-AF (NCT06134739)
- Testing
- No intervention.
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario La Paz
Aortic Valve Stenosis
Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement
This trial is to compare the efficacy of NOAC(Novel Oral Anticoagulants) with edoxaban vs. dual antiplatelet therapy (DAPT) for prevention of leaflet thrombosis (documented by cardiac CT imaging) and cerebral embolization…
- Trial name
- ADAPT-TAVR (NCT03284827)
- Testing
- NOAC, DAPT
- Where
- 5 sites in Hong Kong, South Korea and 1 more
- Volunteers
- 235 people
- Sponsor
- Duk-Woo Park, MD
Coronary Artery Disease, Atherosclerosis
Drug-eluting Balloon in Acute Myocardial Infarction
The investigators hypothesize that patients with Acute ST Elevation Myocardial Infarction may benefit from primary angioplasty with use of a drug eluting balloon/bare metal stent combination without impairing the process of…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Thrombosis, Acute Myocardial Infarction
- Trial name
- DEB-AMI (NCT00856765)
- Testing
- Drug eluting balloon, Bare metal stent, Drug eluting stent
- Where
- 2 sites in Italy, Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Acute Myocardial Infarction (AMI), Left Bundle Branch Block
Machine Learning for Diagnosis of Occlusive MI in LBBB Patients
This study investigates a new way to diagnose severe heart attacks in patients who have a specific electrical heart pattern called a Left Bundle Branch Block (LBBB).
- Conditions
- Acute Myocardial Infarction (AMI), Left Bundle Branch Block, Coronary Occlusion/Thrombosis, Chest Pain
- Trial name
- AI-LBBB (NCT07620119)
- Testing
- Digital 12-Lead ECG Analysis and Invasive Coronary Angiography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Konya City Hospital
Atrial Fibrillation, Cancer
Atrial Fibrillation and Cancer: a Nationwide French Cohort Study
Atrial fibrillation (AF) is a common complication associated with cancer but the risk of AF according to the cancer localization and status as well as the risk of thromboembolisms, bleedings and mortality are poorly known.
- Conditions
- Atrial Fibrillation, Cancer, Thromboembolism, Bleeding
- Trial name
- NCT05563883
- Testing
- event occurence
- Where
- France
- Volunteers
- 5,000,000 people
- Sponsor
- University Hospital, Caen
Acute Coronary Syndrome, Coronary Artery Disease
Comparison of Ticagrelor Versus Clopidogrel on Residual Thrombus Burden During PCI: an OCT Study
Subjects with acute coronary syndromes scheduled for cardiac catheterization will be enrolled in this study. Subjects that are to be treated clinically with coronary artery stenting will be randomized to receive a loading dose of…
- Trial name
- NCT01826175
- Testing
- Ticagrelor, Clopidogrel, Optical Coherence Tomography
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Pulmonary Embolism, Right Heart Strain
Study of Diagnosis and Pathophysiology of Pulmonary Embolism (APE 1 Trial)
The purpose of this study is to investigate which method and criterion for diagnosing pulmonary embolism is the best and determine the relationship between blood vessel constriction and clot size in patients developing heart…
- Trial name
- NCT00302601
- Testing
- Scintigraphic interpretation
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Odense University Hospital
Coronary Disease, Coronary Artery Disease
ABSORB Clinical Investigation, Cohort A (ABSORB A) Everolimus Eluting Coronary Stent System Clinical Investigation
Prospective, open-labeled First in Man Clinical Investigation enrolling patients with visually estimated nominal vessel diameter of 3.0 mm receiving a single 3.0 x 12 mm or 3.0 x 18 mm BVS EECSS containing 98 microgramme per cm²…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ABSORB A (NCT00300131)
- Testing
- Bioabsorbable Everolimus Eluting Coronary Stent
- Where
- 4 sites in Denmark, Netherlands and 2 more
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Hemorrhage, Thrombosis
Anticoagulant Therapy During Pacemaker Implantation
There are no established guidelines regarding interruption of warfarin anticoagulant therapy prior to surgical implantation of cardiac pacemakers.
- Conditions
- Hemorrhage, Thrombosis, Embolism
- Trial name
- FINPAC (NCT00479362)
- Testing
- Warfarin, Aspirin, Permanent pacemaker
- Where
- Finland
- Volunteers
- 447 people
- Sponsor
- University of Turku
Stroke
Cardiac Thrombus in Early Cardiac CT Scan in Etiological Workup of Ischemic Stroke: Prospective Study
Stroke can be linked to atherosclerosis of the large vessels, occlusion of the small intracerebral vessels (gaps), cardioembolic pathology or other rarer etiologies.
- Trial name
- CCT STROKE (NCT04261257)
- Testing
- Cardiac scanner
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Atrial Fibrillation, Medication Adherence
Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation
In patients with non-valvular atrial fibrillation treated with dabigatran etexilate, the level of adherence will be measured using a questionnaire, the Danish National Prescription Registry and pillcount and will be related to…
- Conditions
- Atrial Fibrillation, Medication Adherence, Blood Coagulation Tests, Anticoagulants; Circulating, Hemorrhagic Disorder
- Trial name
- ARCADE (NCT03280368)
- Testing
- Bloodtest, Questionnaires
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Hospitalsenheden Vest
Chronic Total Occlusion of Coronary Artery, Vascular Disease
XIENCE V® USA Dual Antiplatelet Therapy (DAPT) Cohort
XIENCE V USA is a prospective, multi-center, multi-cohort postapproval study. The objectives of this study are To evaluate XIENCE V EECSS continued safety and effectiveness during commercial use in real world settings, and To…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Vascular Disease, Myocardial Ischemia, Coronary Artery Stenosis
- Trial name
- XVU-AV DAPT (NCT01106534)
- Testing
- clopidogrel + aspirin OR prasugrel + aspirin, XIENCE V Everolimus Eluting Coronary Stent System (XIENCE V EECSS)
- Where
- 144 sites in United States
- Volunteers
- 870 people
- Sponsor
- Abbott Medical Devices
Myocardial Infarction
Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease
The purpose of this study is to evaluate the prevalence and morphological features of coronary plaques by means of OCT in patients with acute myocardial infarction but without any significant coronary stenosis at coronary…
- Trial name
- SOFT-MI (NCT02783963)
- Testing
- OCT and CMR imaging
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Pulmonary Embolism, Deep Vein Thrombosis
Therapeutic Initial Heparin Dosing for Patients With Clots or Certain Heart Conditions Admitted to the Hospital
The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient…
- Conditions
- Pulmonary Embolism, Deep Vein Thrombosis, Atrial Fibrillation, Acute Cardiac Syndrome
- Trial name
- NCT07250763
- Testing
- Initial Heparin Dose Modification
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Inova Health Care Services
Myocardial Infarction
Physiologic Assessment of Thrombus Aspiration in Acute ST-segment Elevation Myocardial Infarction Patients
The Physiologic Assessment of Thrombus Aspiration in ST-segment Elevation Myocardial Infarction (PATA-STEMI) trial is a single center, prospective, randomized trial with a planned inclusion of 128 patients with the first…
- Trial name
- PATA-STEMI (NCT01824641)
- Testing
- Eliminate aspiration catheter, Conventional primary angioplasty
- Where
- 2 sites in Serbia
- Volunteers
- 128 people
- Sponsor
- Clinical Centre of Serbia
Atrial Fibrillation, Deep Vein Thrombosis
Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients
The purpose of this study is to determine whether pharmacogenetic guided dosing of warfarin is promising for the improvement of efficiency, therapeutic efficacy, and, especially, safety of warfarin therapy than a dosing regimen…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Heart Valve Disease
- Trial name
- NCT01610141
- Testing
- Genotype-guided warfarin dosing, Non-genotype guided warfarin dosing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Atrial Fibrillation
Assessment of Cardioversion Using Transesophageal Echocardiography II (ACUTE II)
SPECIFIC AIM: To test the safety and feasibility of using low molecular weight heparin (LMWH, enoxaparin sodium; Lovenox, Sanofi-Aventis) in lieu of unfractionated heparin (UFH) as antithrombotic therapy for patients in atrial…
- Trial name
- NCT00289042
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Endocarditis
Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis
The purpose of the EARLY study is to evaluate the efficacy and effectiveness of early surgery in patients with Infective Endocarditis (IE).
- Trial name
- NCT03411499
- Testing
- Early surgery, Conventional therapy
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Maria Vittoria Hospital
Ischemic Stroke, Cardioembolic Stroke
Diagnostic Yield of Cardiac CT to Detect Cardiac Thrombi in Acute Ischemic Stroke: an Individual Patient Data Meta-Analysis
The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac…
- Conditions
- Ischemic Stroke, Cardioembolic Stroke, Thrombus, Cardiac CT
- Trial name
- AIS of HEARTS (NCT07165093)
- Where
- Netherlands
- Volunteers
- 3,940 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)