Clinical trials: Cardiac Thrombus
Coronary Artery Bypass
Prasugrel for Prevention of Early Saphenous Vein Graft Thrombosis
This is a randomized-controlled clinical trial that will randomize 120 patients undergoing clinically-indicated coronary artery bypass graft surgery to prasugrel at a dose of 10 mg daily or matching placebo for 12 months…
- Trial name
- NCT01560780
- Testing
- Prasugrel
- Where
- 4 sites in United States
- Volunteers
- 84 people
- Sponsor
- VA Office of Research and Development
Cardiac Surgery Requiring Cardiopulmonary Bypass, Extracorporeal Circulation
Biocompatible Versus Non-coated Extracorporeal Circuits in Cardiac Surgery
The aim of the present strudy is to investigate whether the use of biocompatible extracorporeal circulation circuits with a special hydrophilic polymer coating without heparin causes a reduction in the activation of the…
- Trial name
- BALANCE (NCT06612060)
- Testing
- Cardiac surgery with the use of extracorporeal circulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Polychronis Antonitsis
Stents, Coronary Artery Disease
SPIRIT III Clinical Trial of the XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
This study is divided into 5 arms: 1. Randomized Clinical Trial (RCT): Prospective, randomized, active-controlled, single blind, parallel two-arm multi-center clinical trial in the United States (US) comparing XIENCE V®…
- Conditions
- Stents, Coronary Artery Disease, Total Coronary Occlusion, Coronary Artery Restenosis
- Trial name
- NCT00180479
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent, TAXUS® EXPRESS2™ Paclitaxel Eluting Coronary Stent
- Where
- 65 sites in United States
- Volunteers
- 1,002 people
- Sponsor
- Abbott Medical Devices
Cardiac Amyloidosis
Prevalence of Cardiac Thrombi in Cardiac Amyloidosis
Cardiac amyloidosis (CA) is an infiltrative disease characterized by deposits of amyloid proteins of genetic or acquired origin (often in elderly patients), leading to heart failure and arrhythmias.
- Trial name
- CATICA (NCT07648303)
- Testing
- Cardiac CT scan with contrast
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Left Atrial Thrombosis
Uses of CMR in Detection of Left Atrial Thrombus
The incidence of rheumatic heart diseases have not declined in our population .Rheumatic heart diseases, often neglected by media and policy makers, is a major burden in developing countries where it causes most of the…
- Trial name
- NCT03662880
- Testing
- Cardiac Magnetic Resonance, Trans-esophageal echo
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Coronary Artery Disease, Myocardial Infarction
Randomized Study to Assess the Effect of ThRombus Aspiration on Flow Area in STEMI Patients
The purpose of the study it to evaluate whether primary percutaneous coronary intervention (primary PCI) with a new thrombectomy device as compared to primary PCI without thrombectomy increases minimal flow area after stenting…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, STEMI
- Trial name
- TROFI (NCT01271361)
- Testing
- primary PCI with thrombectomy, primary PCI without thrombectomy
- Where
- 5 sites in Denmark, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Terumo Europe N.V.
Left Ventricular Assist Device, Heart Failure
Pulse Wave Analysis in Advanced Heart Failure
A comparison of pulse wave characteristics, as measured by peripheral tonometry, in pre and post Left Ventricular Assist Device (LVAD) patients.
- Conditions
- Left Ventricular Assist Device, Heart Failure, Intra-aortic Balloon Pump, LVAD Clot
- Trial name
- PWA-HF (NCT01642927)
- Where
- United States
- Sponsor
- University of Minnesota
Ischemic Heart Disease, Coronary Stenosis
RESOLUTE Asia: Evaluation of the Endeavor Resolute Zotarolimus-Eluting Stent System in a Patient Population With Long Lesion(s) and/or Dual Vessels in Asia
The purpose of this study is to document the safety and overall clinical performance of the Endeavor Resolute Zotarolimus-Eluting Coronary Stent System in a patient population with long lesion(s) and/or dual vessels requiring…
- Conditions
- Ischemic Heart Disease, Coronary Stenosis, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- R-A (NCT01132456)
- Testing
- Drug eluting stent treatment
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Medtronic Vascular
Atrial Fibrillation, Cardioembolic Stroke
Long-term Results of Percutaneous Left Atrial Closure at Brest University Hospital (CLAPOT)
Atrial Fibrillation represents an important risk of cardioembolic stroke. In more than 90% of cases, thrombus originate in the left atrial appendage.
- Conditions
- Atrial Fibrillation, Cardioembolic Stroke, Left Atrial Appendage Thrombosis, Anticoagulant-induced Bleeding
- Trial name
- CLAPOT (NCT06232278)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Brest
COVID, Acute Coronary Syndrome
Cardiovascular Complications and COVID-19 (CovCardioVasc-Study)
Patients with COVID-19 in the Intensive Care Unit (ICU) or hospitalized with severe form have a poor prognosis (almost 30% rate of death).
- Conditions
- COVID, Acute Coronary Syndrome, Myocardial Infarction, Myocarditis
- Trial name
- CovCardioVasc (NCT04335162)
- Where
- 8 sites in France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Coronary Syndrome, ST Elevation Myocardial Infarction
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus…
- Conditions
- Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- ATTRACTIVE (NCT05554588)
- Testing
- Intrathrombus Thrombolysis During Primary PCI, Aspiration Thrombectomy During Primary PCI
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- China-Japan Friendship Hospital
Atrial Fibrillation
Platelet-activation and Optimal Inhibition in Patients With Atrial Fibrillation Undergoing Left Atrial Appendage Occlusion
The POPULAR-LAAO registry is an open-label observational prospective registry to investigate hemostatic processes following left atrial appendage occlusion.
- Trial name
- POPULAR-LAAO (NCT04705688)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- R&D Cardiologie
Coronary Artery Disease (CAD), Ischemic Heart Disease
CAPTURER PMCF Study ( rEPIC04D )
Multicenter, prospective, non-randomized, post-market clinical follow-up (PMCF) study to confirm and support the clinical safety and performance of CAPTURER to meet EU Medical Device regulation (MDR) requirements in all the…
- Trial name
- rEPIC04D (NCT05292079)
- Testing
- CAPTURER
- Where
- 5 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Fundación EPIC
ST Segment Elevation Myocardial Infarction
ST Segment Resolution After Primary Percutaneous Coronary Intervention.
To compare the ST segment resolution after primary percutaneous coronary intervention (PPCI) with and without thrombus aspiration in patients with ST segment elevation myocardial infarction as ST segment resolution is the best…
- Trial name
- STresolution (NCT03895983)
- Testing
- Percutaneous primary coronary intervention
- Volunteers
- 270 people
- Sponsor
- Assiut University
Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism
Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism
The purpose of this study is to examine the degree to which pulmonary embolism (clot) can be dissolved when treated with a very low dose of a systemic thrombolytic drug (clot buster) along with standard anticoagulant therapy as…
- Conditions
- Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism, Pulmonary Embolism With Pulmonary Infarction, Pulmonary Embolism Subacute Massive
- Trial name
- SAFE-LYSE (NCT03988842)
- Testing
- Alteplase, Unfractionated heparin, Apixaban
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Victor Tapson, MD
Blood Clotting
Thromboelastography (TEG®) and Platelet Function in Patients on Anti-platelet Agents
Can a post-operative analysis using a simple blood test (Thromboelastography(TEG®)) and Platelet Mapping Assay (PMA™) be able to detect the occurence of clotting or bleeding complications in patients on blood thinning…
- Trial name
- NCT00901160
- Testing
- blood test
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Pulmonary Embolism
Diclofenac for Submassive PE
The primary objective is to demonstrate the clinical benefits of diclofenac (added to standard anticoagulant therapy) over placebo in normotensive patients with acute symptomatic pulmonary embolism and right ventricular…
- Trial name
- AINEP-1 (NCT01590342)
- Testing
- Diclofenac
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Ministry of Health, Spain
Cardiac Death, Congestive Heart Failure
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
This is an observational study designed to monitor the course of the fraction of reticulated platelets and the correlation thereof to major adverse cardiac and cerebrovascular events after noncardiac surgery.
- Conditions
- Cardiac Death, Congestive Heart Failure, Angina Pectoris, Stroke
- Trial name
- NCT02097602
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Atrial Fibrillation, Deep Vein Thrombosis
Pilot Study: Comparison of Patients' Knowledge of Direct Oral Anticoagulants in Post-hospitalization Between 2 Cardiology Departments Offering or Not a Pharmaceutical Interview During Hospitalization
Direct oral anticoagulants (Rivaroxaban, Apixaban and Dabigatran) are an alternative to anti-vitamin K drugs and low molecular weight heparins in many cardiovascular diseases.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- EDUC-AOD (NCT04674202)
- Testing
- Phone interview
- Where
- 2 sites in France
- Volunteers
- 154 people
- Sponsor
- Direction Centrale du Service de Santé des Armées