Clinical trials: Cardiac Thrombus
Cardiovascular Diseases, Heart Diseases
Novel Hemostatic Cardiac Risk Factors in Framingham
To investigate hemostatic variables in relation to cardiovascular risk in the Framingham Offspring Study cohort.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Death, Sudden, Cardiac, Myocardial Infarction
- Trial name
- NCT00005356
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Community Acquired Pneumonia
Collaborative Healthcare Professionals Approach in Monitoring of Patient Centered Outcomes Through Pathways
The aim of this study is to determine if by providing a collaborative, integrated pathway-based healthcare compared to the usual healthcare, whether or not this would be superior in reducing the length of hospital stay across…
- Conditions
- Heart Failure, Community Acquired Pneumonia, Venous Thromboembolism, Acute Kidney Injury
- Trial name
- CHAMP-Path (NCT01561885)
- Testing
- Pathway-Based Care
- Where
- Saudi Arabia
- Volunteers
- 341 people
- Sponsor
- Majed Aljeraisy
Deep Venous Thrombosis
Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery
A blood clot in the veins, also known as deep venous thrombosis (DVT), is one of the most common complications after surgery. This may result in death if a clot breaks off and travel to the lungs; this is referred to as pulmonary…
- Trial name
- NCT00329433
- Testing
- Desirudin (Iprivask™), Heparin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, Acute Coronary Syndrome
Triple vs. Dual Therapy
Background: The acute coronary syndrome (ACS) is a complication of coronary artery disease (CAD) and associated with increased mortality.
- Trial name
- NCT02080858
- Testing
- Ticagrelor + Apixaban + ASA, Ticagrelor + Apixaban
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Myocardial Infarction, Unstable Angina
PERcutaneouS Coronary intErventions in Patients Treated With Oral Anticoagulant Therapy
Approximately 5 to 8% of patients undergoing percutaneous coronary interventions requires chronic anticoagulant therapy due to atrial fibrillation or other clinical entities.
- Conditions
- Acute Myocardial Infarction, Unstable Angina, Chronic Stable Angina
- Trial name
- PERSEO (NCT03392948)
- Where
- 10 sites in Italy
- Volunteers
- 1,080 people
- Sponsor
- Italian Society of Invasive Cardiology
Pneumonia, Lung Cancer
On Dose Efficiency of Modern CT-scanners in Chest Scans
CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases.
- Conditions
- Pneumonia, Lung Cancer, Pulmonary Embolism, Pulmonary Disease
- Trial name
- NCT04996693
- Testing
- Imaging on Scanner with Spectral Imaging Capabilities, CT Scan using an Energy-Integrating Detector CT (128 slice MDCT), CT Scan using an Energy-Integrating Detector CT (20-slice MDCT)
- Where
- Germany
- Volunteers
- 958 people
- Sponsor
- University Hospital Augsburg
Acute Myocardial Infarction
Thrombus Aspiration in Myocardial Infarction
Treatment of myocardial infarction (blood clot in the arteries of the heart) has improved after introduction of 24/7 balloon angioplasty to open the blocked artery.
- Trial name
- TASTE (NCT01093404)
- Testing
- Thrombus aspiration
- Where
- 29 sites in Denmark, Iceland and 1 more
- Volunteers
- 7,243 people
- Sponsor
- Region Örebro County
Cardiovascular Disease, Surgery
Redesigning Cardiac Surgery to Reduce Neurologic Injury
Neurologic injuries are frequent and devastating complications following cardiac surgery. Previous work conducted by our research group and others has identified the principal mechanisms creating both overt and subtle neurologic…
- Trial name
- NCT00432536
- Testing
- Quality improvement intervention
- Where
- 3 sites in United States
- Volunteers
- 469 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Thrombosis, Cerebral Ischemia
Study of Safety and Biomarker Efficacy of TS23 in Healthy Volunteer
This study is designed to determine the safety, pharmacokinetics and pharmacodynamics of a single intravenous dose of TS23 in healthy adults.
- Conditions
- Thrombosis, Cerebral Ischemia, Venous Thrombosis, Pulmonary Embolism
- Trial name
- TS23Phase1a (NCT03001544)
- Testing
- TS23
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Translational Sciences, Inc.
Acute Coronary Syndrome, ST Elevation Myocardial Infarction
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
This is an multicenter, randomized, controlled, parallel group study. ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(HTB) will be allocated to one of the following: intrathrombus…
- Conditions
- Acute Coronary Syndrome, ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention
- Trial name
- ATTRACTIVE (NCT05554588)
- Testing
- Intrathrombus Thrombolysis During Primary PCI, Aspiration Thrombectomy During Primary PCI
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- China-Japan Friendship Hospital
Coronary Artery Disease
The Optimal Duration of Dual Antiplatelet Therapy After Implantation of Endeavor Stent
The purpose of this study to determine whether the dual antiplatelet therapy (aspirin and clopidogrel) for 3 months after coronary implantation of zotarolimus-eluting stent is safe in terms of death, myocardial infarction, or…
- Trial name
- DATE (NCT00418860)
- Testing
- Aspirin, Clopidogrel
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Thrombolysed
To Compare the Efficacy & Safety of Ultra-Slow (24 hr) Low Dose (25 mg) Infusion of Alteplase Over Slow (24hr) Infusion of Streptokinase in Mechanical Prosthetic Valve Thrombosis
Annual incidence of PVT for mechanical valves is 0.3 - 1.3% patient-yrs. First postoperative year is marked by a 24% incidence of thrombosis.
- Trial name
- PHVT (NCT07360717)
- Testing
- Alteplase, streptokinase
- Where
- India
- Volunteers
- 100 people
- Sponsor
- U. N. Mehta Institute of Cardiology and Research Center
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Chronic Coronary Occlusion, Vascular Disease
XIENCE V® Everolimus Eluting Coronary Stent System USA Post-Approval Study (XIENCE V® USA Long Term Follow-up Cohort)
XIENCE V USA is a prospective, multi-center, multi-cohort post-approval study. The objectives of this study are To evaluate XIENCE V EECSS continued safety and effectiveness during commercial use in real world settings, and To…
- Conditions
- Chronic Coronary Occlusion, Vascular Disease, Myocardial Ischemia, Coronary Artery Stenosis
- Trial name
- XVU-LTF (NCT01120379)
- Testing
- XIENCE V® EECSS
- Where
- United States
- Volunteers
- 5,034 people
- Sponsor
- Abbott Medical Devices
COVID, Acute Coronary Syndrome
Cardiovascular Complications and COVID-19 (CovCardioVasc-Study)
Patients with COVID-19 in the Intensive Care Unit (ICU) or hospitalized with severe form have a poor prognosis (almost 30% rate of death).
- Conditions
- COVID, Acute Coronary Syndrome, Myocardial Infarction, Myocarditis
- Trial name
- CovCardioVasc (NCT04335162)
- Where
- 8 sites in France
- Volunteers
- 198 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Heart Valve Disease
Prospective Randomized On-X Versus SJM Evaluation Trial
The study hypothesizes that rate of thromboembolic complications of the On-X prosthesis is reduced as compared to the SJM prosthesis.
- Trial name
- PROSE (NCT00639782)
- Testing
- On-X Heart valve replacement, SJM Heart valve replacement
- Where
- 28 sites in United States, Australia and 7 more
- Volunteers
- 857 people
- Sponsor
- On-X Life Technologies, Inc.
Intracardiac Thrombus, STEMI
Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus
Left ventricular thrombus is found in 10 to 25% of patients with impaired left ventricular function following ST-segment elevation myocardial infarction and up to 20% in dilated cardiomyopathy in observational studies.
- Conditions
- Intracardiac Thrombus, STEMI, Heart Failure
- Trial name
- ARGONAUT (NCT05825573)
- Testing
- Vitamin K antagonist, Direct oral anticoagulant
- Where
- 35 sites in France, Reunion
- Volunteers
- 340 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prosthesis-Related Infections, Equipment Failure
Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers
The growing use and the expanding indications for cardiovascular implantable electronic devices (CIEDs) have been associated to an increase of device removal.
- Conditions
- Prosthesis-Related Infections, Equipment Failure, Heart Failure, Arrhythmias
- Trial name
- GAINE LASER (NCT03121183)
- Testing
- Laser sheath, Implantable Cardiac Device lead extraction
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heparin-Induced Thrombocytopenia
Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia
The purpose of the study is to evaluate efficacy and safety of argatroban in the patients with heparin-induced thrombocytopenia (HIT)/ HIT and thrombosis syndrome (HITTS).
- Trial name
- NCT00198588
- Testing
- argatroban
- Where
- 20 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan