Clinical trials: Cardiac Thrombus
Heart Failure
Tissue Factor Expression in Stage C Heart Failure
Monocyte tissue factor (TF) was characterized in Class C heart failure (HF) vs. 25 age-matched volunteers. TF was 2.9 fold higher (p < 0.001) in HF patients vs. controls.
- Trial name
- TFHF (NCT00935740)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cardiovascular Diseases, Coronary Disease
Dietary Effects on Lipoproteins and Thrombogenic Activity
To evaluate the effects of carefully controlled diets on lipoproteins and clotting factors in different demographic groups.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Coronary Heart Disease Risk Reduction, Heart Diseases
- Trial name
- DELTA (NCT00000538)
- Testing
- diet, fat-restricted
- Volunteers
- 189 people
- Sponsor
- University of North Carolina, Chapel Hill
Atrial Fibrillation, Intracardiac Thrombus
Response of Intracardiac Thrombus to Anticoagulants in Patients With Non-valvular Atrial Fibrillation (LYSIS)
This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus.
- Trial name
- LYSIS (NCT06141538)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Coronary Artery Disease, Percutaneous Coronary Intervention
NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
The goal of this clinical trial is to compare short-term Triple Antithrombotic Therapy (DAPT + Rivaroxaban) followed by DAPT with standard DAPT in selected ACS patients with high ischemic risk.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome
- Trial name
- NCT05638867
- Testing
- Aspirin + Clopidogrel + Rivaroxaban, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 3,944 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, Platelet Thrombus
Fixed-dose vs. Phenotype-based PrAsugrel Dose to MATCH Therapeutic Zone in Asians With Acute Coronary Syndrome
The purpose of this study is to determine whether the fixed-dose (prasugrel 10 mg/d vs. 5 mg/d) vs. phenotype (platlet function test by VerifyNow P2Y12 assay)-based prasugrel dose adjustment can match therapeutic zone of platelet…
- Conditions
- Acute Coronary Syndrome, Platelet Thrombus, Bleeding
- Trial name
- NCT01951001
- Testing
- Prasugrel
- Where
- South Korea
- Volunteers
- 255 people
- Sponsor
- Gyeongsang National University Hospital
Cardiovascular Diseases, Coronary Disease
Inflammation Markers Over Time in Cardiovascular Disease
To determine inflammation markers over time in cardiovascular disease. To test the hypothesis that measures of coagulation and fibrinolysis correlate with the incidence of coronary heart disease (CHD) and other thrombosis related…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Thrombosis
- Trial name
- NCT00005692
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction
Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.
The purpose of this study is to determine if intense control of high glucose levels in patients treated with angioplasty for heart attack has anti-inflammatory and anti-thrombotic effects.
- Trial name
- NCT00209144
- Testing
- Intensive insulin therapy
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Atrial Fibrillation
REgistry on Real-Life EXperience With Left Atrial Appendage Occlusion
The objective of this observational non-randomized multicenter study is to compile real-world clinical characteristics and outcomes data for patients treated with LAA (left atrial appendage) closure systems in a daily clinical…
- Trial name
- RELEXAO (NCT03279406)
- Testing
- Percutaneous Left Atrial Appendage Occlusion
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours
Acute Coronary Syndrome, Thrombosis
Hormones Inflammation and Thrombosis
The investigators are attempting to determine if the response to aspirin in women is related to the level of estrogen and progesterone that a woman has.
- Trial name
- HIT2 (NCT01875185)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Atrial Fibrillation, Cardiovascular Diseases
LAAC-registry: Clinical Outcome After Echocardiography-guided LAA-closure
The study aims at comparing, in a large cohort of consecutive clinically indicated left atrial appendage closure, clinical and imaging outcomes between different subpopulations.
- Conditions
- Atrial Fibrillation, Cardiovascular Diseases, Thromboembolism
- Trial name
- NCT04628078
- Testing
- Use of echocardiography guidance for LAAC
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Arterial Occlusive Diseases, Myocardial Ischemia
RESOLUTE Japan - The Clinical Evaluation of the MDT-4107 Drug-Eluting Coronary Stent
The objective of the study is to verify the safety and efficacy of the MDT-4107 Drug-Eluting Coronary Stent for the treatment of de novo lesions in native coronary arteries.
- Conditions
- Arterial Occlusive Diseases, Myocardial Ischemia, Cardiovascular Diseases, Coronary Artery Disease
- Trial name
- RJ (NCT00927940)
- Testing
- MDT-4107 Drug Eluting Stent
- Where
- 14 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Medtronic Vascular
Contraception, Female Contraception
Postmarketing Study of ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) in Relation to Venous Thromboembolism (Blood Clots), Stroke and Heart Attacks
The purpose of the study is to assess the occurrence of venous thromboembolism (blood clots), stroke, and heart attack in current users of ORTHO EVRA compared to current users of norgestimate-containing oral contraceptives with…
- Trial name
- NCT00331071
- Testing
- Monophasic or triphasic Oral contraceptive tablet, Ortho Evra transdermal patch containing 6 mg NGMN/0.75 mg EE
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Myocardial Infarction
THE LASER-AMI STUDY - Excimer Laser Versus Manual Thrombus Aspiration in Acute Myocardial Infarction
The occurrence of no-reflow phenomenon after recanalization of the infarct related artery in acute myocardial infarction is described in up to 40% of cases.
- Trial name
- LASER-AMI (NCT01826006)
- Testing
- Excimer laser, Manual Thrombus Aspiration
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Catholic University of the Sacred Heart
Coronary Artery Disease, Restenosis
Culotte Technique Versus TAP Stunting for the Treatment of de Novo Coronary Bifurcation Lesion With Drug-eluting Stents
BBK- 2 - study: STUDY-SUMMARY Background: The need for stenting of the main and side branch (double stenting) in the treatment of coronary bifurcation lesion primarily depends on the complexity of the bifurcation lesion.
- Trial name
- BBK2 (NCT01267838)
- Testing
- PCI
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Atrial Fibrillation, Deep Venous Thrombosis
Modeling Genotype and Other Factors to Enhance the Safety of Coumadin Prescribing
The study goal is to conduct a randomized controlled trial to compare safety and accuracy of dosing based on clinical information including the clinical reason for your taking coumadin, your age, gender, your body surface area…
- Conditions
- Atrial Fibrillation, Deep Venous Thrombosis, Heart Valve Replacement, Pulmonary Embolism
- Trial name
- NCT00484640
- Testing
- Coumadin
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Cardiac Catheterization, Retina
Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization
Retinal emboli is a common phenomenon in cardiac catheterization. In this study the investigators evaluate the incidence of retinal emboli post diagnostic and therapeutic cardiac catheterization over 300 patients.
- Conditions
- Cardiac Catheterization, Retina, Embolism
- Trial name
- NCT01157338
- Testing
- diagnostic cardiac catheterization, therapeutic cardiac catheterization
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shiraz University of Medical Sciences
Cardiovascular Diseases, Heart Diseases
Raynaud's Treatment Study (RTS)
To determine the relative efficacy of usual medical care and a course of treatment by thermal biofeedback in reducing vasospastic attacks characteristic of Raynaud's syndrome.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Raynaud's Disease, Vascular Diseases
- Trial name
- NCT00000530
- Testing
- nifedipine, biofeedback (psychology), electromyography
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Defects, Congenital
Long Term Safety of Clopidogrel in Neonates/Infants With Systemic to Pulmonary Artery Shunt Palliation
This study is the extension of the CLARINET study [NCT00396877 -EFC5314] in neonates or infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary artery shunt.
- Trial name
- CLARINET LT (NCT00833703)
- Testing
- Clopidogrel
- Where
- 15 sites in United States, Brazil and 13 more
- Volunteers
- 49 people
- Sponsor
- Sanofi
Coronary Artery Disease
The E-SERIES Registry for Supralimus® Coronary Stent for the Treatment of Unselected Patients With Coronary Lesions
E-SERIES Registry evaluate the procedural and clinical outcomes of the Supralimus® SES in the treatment of unselected, high risk patients having coronary Artery blockage in the real world clinical practice.
- Trial name
- NCT01368627
- Testing
- Supralimus® Sirolimus-Eluting Coronary Stent
- Where
- 7 sites in Brazil
- Volunteers
- 1,274 people
- Sponsor
- Sahajanand Medical Technologies Limited
Thromboembolism, Deep Vein Thrombosis
DVT After Cardiac Procedure
Patients undergoing electrophysiology studies (EPS) and cardiac ablation procedure for the treatment of cardiac arrhythmias may be at increased risk of deep vein thrombosis (DVT) during or after the procedure, which may lead to…
- Trial name
- NCT03877770
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Manchester University NHS Foundation Trust