Clinical trials: Cardiac-Related Conditions
Stroke, Ischemic, Device Related Thrombosis
APPEND-CT Registry
The APPEND-CT registry is an investigator-driven multicenter retrospective observational database intended to compile cardiac CT follow-up data after Watchman FLX device implantation and function as a platform for answering…
- Conditions
- Stroke, Ischemic, Device Related Thrombosis, Atrial Fibrillation
- Trial name
- APPEND-CT (NCT06213285)
- Testing
- Watchman FLX left atrial appendage occlusion
- Where
- 2 sites in United States, Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Breast Neoplasm Malignant Primary
TRUST-ACE - Anticancer-treatment Cardiotoxicity Identification by Echocardiography
TRUST-ACE will compare a simplified echocardiographic protocol focusing on ventricular function with the guideline recommended comprehensive echocardiographic examination using a randomised design in follow-up of breast-cancer…
- Trial name
- TRUST-ACE (NCT06310330)
- Testing
- Comprehensive echocardiographic follow-up, Simplified echocardiographic follow-up
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Norwegian University of Science and Technology
Cardiotoxicity, Heart Failure
MyoStrain CMR for the Detection of Cardiotoxicity
The Prefect Pilot Study evaluates the use of the EC approved MyoStrain SENC CMR Imaging System to detect cardiotoxicity from drugs used to treat cancer (e.g. Breast Cancer and Lymphomas).
- Conditions
- Cardiotoxicity, Heart Failure, Chemotherapeutic Toxicity
- Trial name
- Prefect (NCT03543228)
- Testing
- MyoStrain
- Where
- Germany
- Volunteers
- 63 people
- Sponsor
- Myocardial Solutions
Myocardial Infarction, Cardiogenic Shock
Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
- Trial name
- IABPSHOCK (NCT00469248)
- Testing
- Intra-aortic balloon pump counterpulsation
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Functional Decline, Hospitalization-associated Disability
Incidence and Risk Factors for Hospitalization-Associated Disability
This prospective cohort study aims to determine the incidence of hospitalization-associated disability and its association with risk factors at the patient level and with care and hospital processes.
- Conditions
- Functional Decline, Hospitalization-associated Disability, Iatrogenic Disease
- Trial name
- NCT02572999
- Testing
- Not applicable (observational design)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents
Cardiac Arrhythmia Telemetry; Conventional vs HeartWatch
Heart rhythm disorders are common and significantly impact the lives of those affected and their families. The main problems can be categorized as: a) atrial fibrillation or AF and atrial flutter, b) supra-ventricular tachycardia…
- Conditions
- Cardiac Arrhythmia, Diagnostic/Monitoring Devices Related to Adverse Incidents, Atrial Fibrillation (AF)
- Trial name
- CATCH (NCT06164808)
- Testing
- HeartWatch
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- HelpWear Inc.
Breast Cancer, Cardiac Toxicity
Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, fluorouracil, epirubicin hydrochloride, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Conditions
- Breast Cancer, Cardiac Toxicity, Perioperative/Postoperative Complications
- Trial name
- NCT01093235
- Testing
- bevacizumab, cyclophosphamide, docetaxel
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Locally Advanced Lung Non-Small Cell Carcinoma
Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)
The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy.
- Trial name
- LM (NCT06361784)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Postoperative Delirium, Elective Non-Cardiac Surgery
Correlation Between Blood Biomarkers and Postoperative Delirium in Elective Non-Cardiac Surgery.
More than 20% of patients over 60 years old develop postoperative delirium following non-cardiac surgery . Delirium increases morbidity and mortality , and may lead to long-term cognitive impairment .
- Trial name
- NCT03915314
- Testing
- Neuropsychological tests
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuzhou Medical University
Sudden Unexplained Infant Death, Apnea of Newborn
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age).
- Conditions
- Sudden Unexplained Infant Death, Apnea of Newborn, Newborn Morbidity, Newborn Asphyxia
- Trial name
- AWARD (NCT06693817)
- Testing
- Wireless skin sensors vital sign monitoring system, Wired vital sign monitoring system
- Where
- 5 sites in Brazil, Canada and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guilherme Sant'Anna, MD
Critical Illness
Critical Illness Related Cardiac Arrest (CIRCA)
CIRCA aims to determine the incidence and outcomes of in-hospital cardiac arrest (IHCA) in UK intensive care units (ICUs) and explore associated risk factors with ICU and hospital survival and quality of survival following…
- Trial name
- CIRCA (NCT04219384)
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- Intensive Care National Audit & Research Centre
Myocardial Infarction, Thrombosis, Coronary
OFDI-Quantified Intracoronary Thrombus, Antiplatelet Pretreatment Effect and Myocardial Reperfusion
The management of ST-elevation myocardial infarction in the acute phase requires an optimal antiaggregation combining aspirin and a P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor).
- Trial name
- ODIPP (NCT03342521)
- Testing
- optical coherence tomography and VerifyNow
- Where
- France
- Volunteers
- 63 people
- Sponsor
- University Hospital, Caen
Cardiovascular Diseases, Type 2 Diabetes
HEART Kitchen Pilot
This study is testing a 28-day healthy eating program for adults who live in public housing and are at risk for heart disease. The program helps people eat more whole plant foods, like fruits, vegetables, beans, and whole grains…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes, Obesity and Obesity-related Medical Conditions
- Trial name
- HEARTKITCHEN (NCT07037121)
- Testing
- Whole Food Plant Based Diet Jumpstart
- Where
- United States
- Sponsor
- Reya Andrews
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Obesity Associated Disorder, Myocardial Infarction
Association of Obesity and Cardiovascular Outcomes in Myocardial Infarction
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients with Myocardial Infarction who underwent percutaneous…
- Trial name
- Paradox (NCT05645926)
- Testing
- Percutaneous coronary intervention (PCI), Coronary artery bypass grafting (CABG)
- Where
- South Korea
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Frailty, Cardiac Surgery
Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients
This prospective observational study aims to evaluate the association between preoperative frailty and the procedural difficulty of ultrasound-guided internal jugular vein catheterization in adult patients undergoing elective…
- Conditions
- Frailty, Cardiac Surgery, Central Venous Catheter
- Trial name
- FRAILCVC (NCT07701538)
- Testing
- Ultrasound-Guided Internal Jugular Vein Catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ankara City Hospital Bilkent
Cardiotoxicity Induced by Drug Therapy for Breast Cancer
The Use of Shengmai San to Prevent Anthracycline Sequential Trastuzumab Therapy Related Cardiac Toxicity
To evaluate the effectiveness and safety of Shengmai San in preventing anthracycline sequential trastuzumab therapy related cardiac toxicity through a prospective randomized controlled study.
- Trial name
- START (NCT06214195)
- Testing
- Shengmai San (ingredients include ginseng, Ophiopogon japonicus, and Schisandra chinensis)
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Zhejiang Cancer Hospital
Breast Cancer, Breast Tumors
Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer
The goal of this study is to determine if co-administration of metformin and doxorubicin in breast cancer patients receiving neoadjuvant or adjuvant therapy will reduce the number of patients who develop a significant change in…
- Trial name
- NCT02472353
- Testing
- Metformin, Doxorubicin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Paroxysmal Atrial Fibrillation
Baroreflex Sensitivity in Patients Undergoing Ablation of Atrial Fibrillation
Atrial fibrillation is the most common arrhythmia. The posterior surface of the left atrium is covered by an extensive network belonging to the autonomic nervous system that can be damaged during the ablation.
- Trial name
- BARO-AF (NCT04503122)
- Testing
- pulmonary vein isolation
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Poitiers University Hospital