Clinical trials: Cardiac-Related Conditions
Coronary Artery Disease, Postoperative Complications
Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers
The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative…
- Conditions
- Coronary Artery Disease, Postoperative Complications, Anesthesia
- Trial name
- NCT06209437
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people
- Sponsor
- Ankara City Hospital Bilkent
Chronic Kidney Diseases, Dialysis; Complications
Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio to Predict Carotid Intima-Media Thickness in Chronic Kidney Disease Patients
This study aims to determine whether the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can be used as predictors of coronary heart disease (CHD) in CKD patients undergoing dialysis at Moewardi General…
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Coronary Heart Disease
- Trial name
- NCT05472805
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Universitas Sebelas Maret
Lymphoma, Large B-Cell
Study Investigating the Cardiotoxicity of Anthracyclines in Patients With Diffuse Large B-Cell
All patients enrolled in the study will have to be treated with a chemo immunotherapy scheme R-CHOP with doxorubicin, with doxorubicin analogue or non pegylated liposomal anthracycline (R-COMP; Sec.
- Conditions
- Lymphoma, Large B-Cell, Diffuse Large B-Cell
- Trial name
- NCT02916316
- Testing
- R-CHOP with doxorubicin
- Where
- 18 sites in Italy
- Volunteers
- 127 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Atrial Fibrillation, Arrhythmias, Cardiac
Predicting Risk of Atrial Fibrillation and Association With Other Diseases
Atrial fibrillation (AF) is a major public health issue: it is increasingly common, incurs substantial healthcare expenditure, and is associated with a range of adverse outcomes.
- Conditions
- Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- FIND-AF (NCT05837364)
- Testing
- Development of an algorithm
- Where
- United Kingdom
- Volunteers
- 2,159,663 people
- Sponsor
- University of Leeds
Cardiotoxicity
Cardiotoxicity Monitoring With Single-lead Electrocardiogram
This research is a multi-center prospective cohort interventional study aimed to determinate the capabilities of remote 1-minute single-lead electrocardiogram monitoring for cardiotoxicity detection, during two- three weeks…
- Trial name
- NCT05676606
- Testing
- Remote 1-minute single-lead electrocardiogram (ECG) monitoring in cancer patients after the first polychemotherapy cycle.
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
Breast Cancer, Thalassemia Minor
Cardiac Management of Patients With Thalassemia Minor and Breast Cancer
This retrospective study aimed to evaluate the demographic characteristics, clinical conditions in term of physical examination findings), functional status, and laboratory results of patients with thalassemia minor (TM) and…
- Conditions
- Breast Cancer, Thalassemia Minor, Heart Diseases
- Trial name
- AQUA (NCT05960214)
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istanbul University
Myocardial Infarction, Myocardial Ischemia
Coronary Flow and Myocardial Viability: the FloVITA Study
Evaluation of fractional flow reserve (FFR) is a key method for assessing ischemia with a view to guiding revascularization strategy following acute coronary syndrome.
- Trial name
- FloVita (NCT04818918)
- Testing
- Absolute coronary flow measurement, Microvascular resistance measurement, Cardiac MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Atrial Tachycardia
The RIPPLE AT-PLUS Study
Atrial tachycardia is a symptomatic arrhythmia, for which an effective treatment is a catheter ablation procedure. The goal of the Ripple AT-Plus study is to evaluate two methods of performing catheter ablation for atrial…
- Trial name
- NCT03915691
- Testing
- Catheter ablation of atrial tachycardia: Ripple Mapping guided., Catheter ablation of atrial tachycardia: Conventional mapping guided.
- Where
- 3 sites in United Kingdom
- Volunteers
- 201 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Congenital Disorders
Radiofrequency Ablation of Ectopic Atrial Tachycardia
A retrospective chart review will be performed on 50 patients who received RFA for the treatment of EAT between August 1992 and August 2003 at Children's Healthcare of Atlanta.
- Trial name
- NCT00267982
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Healthcare of Atlanta
Cardiac Toxicity, VEGF
Effects of Anti-VEGF Targeted Drugs on Patients' Blood Pressure and Endothelial Function
Explore the effects of anti-VEGF targeted drugs on blood pressure and endothelial function in cancer patients.
- Conditions
- Cardiac Toxicity, VEGF, Endothelial Dysfunction
- Trial name
- NCT04962438
- Testing
- Anti-VEGF
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University Third Hospital
Long QT Syndrome, Brugada Syndrome
Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations
The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome…
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- QUALIMYORYTHM (NCT04712136)
- Testing
- MRI
- Where
- France
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
BTKi-induced Atrial Fibrillation, Hematologic Malignancy
IRAF-ABLATION Study: a Multicenter International Retrospective Cohort of Patients With BTK Inhibitors-related AF Treated by Catheter Ablation
Targeted anticancer drugs have completely changed the prognosis of malignancies during the past decades. Patients suffering from malignancies live longer and this allows adverse events of anticancer drugs to emerge, notably…
- Conditions
- BTKi-induced Atrial Fibrillation, Hematologic Malignancy, Atrial Fibrillation Catheter Ablation
- Trial name
- NCT06130709
- Testing
- Atrial fibrillation catheter ablation in a population of BTKi-induced atrial fibrillation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Postoperative Cognitive Dysfunction
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques
Postoperative cognitive decline (POCD) is a frequent complication after cardiac surgery. It is estimated that 40-70% of all cardiac patients show cognitive dysfunction during the first post-surgical week.
- Trial name
- CardChNeuroMRI (NCT01622452)
- Volunteers
- 50 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
Spinal Anesthesia, Cardiac Toxicity
Cardiovascular Effects of Intrathecal Hyperbaric Prilocaine or Bupivacaine in Surgery Under Spinal Anesthesia
Spinal anesthesia remains a mainstay in lower limbs- as in day-case surgeries as well. It consists in injecting a local anesthetic drug into the intrathecal space of a patient's spinal canal.
- Trial name
- NCT05751148
- Testing
- Hyperbaric bupivacaïne, Hyperbaric prilocaïne
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Secondary Hyperparathyroidism, Disorder Related to Renal Transplantation
Morbidity Related to Secondary Hyperparathyroidism After Renal Transplantation
The purpose of the study is to evaluate the long term vascular morbidity and mortality in kidney transplant recipients based on one year post transplant levels of intact parathyroid hormone.
- Trial name
- SHPT-RT (NCT01741064)
- Volunteers
- 257 people
- Sponsor
- Skane University Hospital
Locally Advanced Lung Non-Small Cell Carcinoma
Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)
The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy.
- Trial name
- LM (NCT06361784)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cardiac Toxicity, Antitumor Drugs
Risk Assessment Model of Trastuzumab-related Cardiotoxicity in Breast Cancer Patients
According to the existing clinical data in our hospital, retrospective study was conducted to screen the risk factors with predictive value for TRC(trastuzumab-related cardiotoxicity) risk, and to construct the risk prediction…
- Conditions
- Cardiac Toxicity, Antitumor Drugs, Breast Cancer
- Trial name
- NCT04962425
- Testing
- Trastuzumab
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University Third Hospital
Atrial Fibrillation, Device Related Thrombus
Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).
Single arm, prospective unblinded study on post Watchman LAA closure device implant anti-coagulation management at a primary center (Vanderbilt Medical Center) and up to 5 additional high volume LAA implant centers.
- Conditions
- Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device
- Trial name
- DEA-LAA (NCT03539055)
- Testing
- Dabigatran Etexilate Oral Capsule
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Cardiotoxicity, Anthracycline-induced Cardiotoxicity
Serial Cardiac Magnetic Resonance Imaging (CMR) With Contrast Agents and Biomarker Analysis for the Detection of Cardiotoxicity Under Anthracycline-containing Cancer Therapy
The goal of the trial is the early detection of cardiotoxicity in patients treated with anthracycline-based chemotherapy. Current diagnostics, such as troponin T, NT-pro-BNP, electrocardiogram, and echocardiography, are not able…
- Trial name
- CMR-Onko (NCT07528586)
- Testing
- CMR based measurement of cardiotoxicity, biosampling for scientific research in study-specific biobank
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)