Clinical trials: Cardio Pulmonary Bypass
Lung Injury, Cardiopulmonary Bypass
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality.
- Trial name
- NCT04296071
- Testing
- Research study
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sophia Koutsogiannaki
Congenital Heart Disease in Children, Cardiopulmonary Bypass
The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of Fallot
Congenital heart disease (CHD) is the most common congenital abnormality found in newborns with Tetralogy of Fallot (TOF) being the most common cyanotic CHD.
- Conditions
- Congenital Heart Disease in Children, Cardiopulmonary Bypass, Tetralogy of Fallot
- Trial name
- NCT05579964
- Testing
- Dexmedetomidine Hcl 100 Mcg/mL Inj
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Coronary Disease
Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass
The purpose of this trial is to identify a dose or doses of INS50589 intravenous infusion that are well-tolerated and which reduce postoperative bleeding and blood product transfusion.
- Trial name
- NCT00316212
- Testing
- INS50589 Intravenous Infusion
- Where
- 27 sites in United States
- Volunteers
- 160 people
- Sponsor
- Merck Sharp & Dohme LLC
Pediatric Cardiac Surgery
Influence of Inotropic Choice on Morbidity and Mortality in Complex Pediatric Heart Surgery
Our study is based on the observation that management of the cardiopulmonary by-pass withdrawal in pediatric heart surgery is quite variable between medical teams.
- Trial name
- CHUBpedCSino (NCT04380181)
- Testing
- dobu
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Brugmann University Hospital
Coronary Heart Disease (CHD), Cardio-pulmonary Bypass
Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery
Enhanced external counterpulsation (EECP) is a noninvasive, non-pharmacologic intervention proven to increase nitric oxide bioavailability in patients with coronary artery disease.
- Conditions
- Coronary Heart Disease (CHD), Cardio-pulmonary Bypass, Congestive Heart Failure Chronic, Cardiogenic Shock Acute
- Trial name
- PANDA (NCT06728605)
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Glucose Metabolism Disorders (Including Diabetes Mellitus)
Continuous Glucose Monitoring in Patients Undergoing Cardiopulmonary Bypass
The purpose of this research study is to test the accuracy of the Dexcom continuous glucose monitoring device during the cardiothoracic surgical procedure and recovery period in the Cardiac Intensive Care Unit.
- Trial name
- NCT06861881
- Testing
- Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Bypass, Myocardial Infarction
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.
- Conditions
- Coronary Artery Bypass, Myocardial Infarction, Ventricular Dysfunction, Left, Stroke
- Trial name
- RED-CABG (NCT00872001)
- Testing
- Acadesine, Normal Saline
- Volunteers
- 3,080 people
- Sponsor
- Merck Sharp & Dohme LLC
Valvular Heart Disease
The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass
This study evaluates the enhanced recovery after surgery (ERAS) concept over conventional postoperative care in patients with heart valve disease undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- ERAS (NCT02479581)
- Testing
- ERAS group, Conventional control group
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Xiangya Hospital of Central South University
Heart Valve Surgery
Characterizations of Gut Microbiota and Postoperative Sleep in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
- Trial name
- NCT05136001
- Testing
- polysomnography
- Where
- China
- Volunteers
- 36 people
- Sponsor
- China Medical University, China
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Cardiac Surgery Requiring Cardiopulmonary Bypass
Vancomycin Concentration Analysis in Post-Cardiac Surgery Patients
The benefits of antimicrobial prophylaxis for cardiac surgery have been clearly demonstrated in placebo-controlled studies. Prophylactic intravenous antibiotics are therefore administered, with agent selection directed against…
- Trial name
- NCT07087301
- Testing
- subtherapeutic concentration risk group
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Pengqiang Du
Coronary Disease
Impact of Pumps on Internal Thoracic Arteries (IPITA)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory…
- Trial name
- IPITA (NCT04168853)
- Testing
- vascular reactivity of internal thoracic arteries
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Coronary Artery Disease, Coronary Artery Bypass Surgery
Double-Blind Comparison of Combined General-Spinal Anesthesia to General Anesthesia for Coronary Artery Surgery
Use of neuraxial agents in anesthesia for cardiac surgery is expanding. We have used combined general-spinal anesthesia for cardiac surgery for 12 years.
- Trial name
- NCT00242697
- Testing
- spinal analgesia and anesthesia for coronary artery surgery
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- University of Calgary
Post Operative Care After Cardiac Surgery With Cardio Pulmonary Bypass
Bio Impedance Electrical Analysis to Predict Outcome After Cardiac Surgery
Phase angle determined by bioelectrical impedance analysis is a strong prognostic factor in several medical areas as clinical nutrition, nephrology, infectious disease, oncology.
- Trial name
- BiPOCS (NCT05229159)
- Testing
- Bioelectrical impedance analysis
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Hematologic Changes
Effect of Blood Harvesting and Administration at End of CPB on Coagulation Profile
Blood transfusions after pediatric heart surgery is a relatively common practice occurring in up to 46% of patients, however its use has been associated with increased morbidity.
- Trial name
- NCT01958242
- Testing
- Preoperative blood harvesting
- Where
- Israel
- Sponsor
- Rabin Medical Center
Cardiac Surgery, Congenital Heart Defects
Intraoperative Dexamethasone in Pediatric Cardiac Surgery
Perioperative administration of steroids has been demonstrated to reduce systemic inflammatory response in infants undergoing cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiac Surgery, Congenital Heart Defects, Cardiopulmonary Bypass
- Trial name
- NCT02615262
- Testing
- Dexamethasone
- Where
- 4 sites in Brazil, China and 1 more
- Volunteers
- 394 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cardiac Disease, Extracorporeal Circulation; Complications
PErfusion QUality ODds
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication after cardiac operations with cardiopulmonary bypass (CPB) use. Its frequency varies depending on the severity grade.
- Conditions
- Cardiac Disease, Extracorporeal Circulation; Complications, Perfusion; Complications, Acute Kidney Injury
- Trial name
- PEQUOD (NCT06019546)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Policlinico S. Donato
Patient Undergoing CABG Surgery, Ischemic Heart Disease Patients
Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass
This trial aims to study the performance of CO2 gap, lactate level, and central venous oxygen saturation in predicting major postoperative complications after cardiac surgery with cardiopulmonary bypass
- Trial name
- NCT06839027
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Ain Shams University
Cardiac Surgery, Cardiopulmonary Bypass
Endocan Blood Level in Pulmonary Circulation
Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Lung
- Trial name
- ENDOPULM (NCT04616820)
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiopulmonary Bypass, Cardiac Surgery
Oxygen Delivery During Cardiopulmonary Bypass And Inflammatory Reaction After Cardiac Surgery
Cardiac surgery, especially when involving cardiopulmonary bypass (CPB), has long been associated with a systemic inflammatory response that can lead to a range of complications, from mild symptoms to severe organ dysfunction…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Systemic Inflammatory Response Syndrome (SIRS)
- Trial name
- OXYINFLAMM (NCT06993467)
- Where
- 2 sites in Italy
- Volunteers
- 908 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti