Clinical trials: Cardio Pulmonary Bypass
Acute Kidney Dysfunction
Cardiopulmonary-bypass and Reno-protective Effect of Atorvastatin Trial
Acute kidney dysfunction is common after cardiac surgery. While many patients suffer no long-term ill effects from post-operative kidney dysfunction, some require initiation of dialysis therapy that can contribute to long-term…
- Trial name
- CREAT (NCT00910221)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Austin Health
Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease
Transfusion in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB).
- Trial name
- TICVS (NCT06332547)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Guangdong Provincial People's Hospital
Postoperative Pain, Postoperative Atelectasis
Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries
Pain management is important after coronary artery bypass graft (CABG) surgery. Intravenous morphine is the gold standard for pain relief, but its sedation, cough suppression and decreased bowel movements limit its use.
- Conditions
- Postoperative Pain, Postoperative Atelectasis, Analgesia
- Trial name
- NCT06267443
- Testing
- Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
Cardiac Surgical Procedures
Low Dose Dexmedetomidine and Delirium After Cardiac Surgery
Delirium after cardiac surgery can occur in up to 50% of the patients and has been shown to be significantly associated with increased morbidity and mortality. Advanced age is a significant risk factor of delirium.
- Trial name
- LOWDEXDEL (NCT03388541)
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 420 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Granulocyte Immature Forms, Inflammatory Response Syndrome, Systemic
Bands in Peripheral Blood After Coronary Artery Bypass Grafting With and Without Cardiopulmonary Bypass
Coronary artery bypass graft (CABG) surgery is associated with reperfusion syndrome and activation of inflammatory reaction (SIRS). These are more exaggerated when cardiopulmonary bypass (CPB) is used.
- Trial name
- NCT00563030
- Where
- Poland
- Volunteers
- 44 people
- Sponsor
- Medical University of Gdansk
Coronary Artery Disease, Cardiac Disease
Effects of Early Telerehabilitation in Coronary Artery Bypass Surgery Patients
The aim of this study was to investigate the effects of phase I and early phase II rehabilitation with telerehabilitation method and sleep hygiene training on physical capacity, cardiac functions, anxiety level, quality of life…
- Trial name
- NCT06240702
- Testing
- Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Necmettin Erbakan University
Acute Kidney Injury
Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality
Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are…
- Trial name
- NCT02916043
- Testing
- Cardiovascular surgery with cardiopulmonary bypass
- Where
- South Korea
- Volunteers
- 1,099 people
- Sponsor
- Seoul National University Hospital
Cardiac Surgery-associated Acute Kidney Injury
A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries.
- Trial name
- NCT06772025
- Testing
- No investigational study intervention
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Bayer
Psychological Stress, Cardiopulmonary Bypass Surgery
CARINAE for Stress Relief in Perioperative Care
Preventing pre-surgical stress can help patients achieve positive outcomes on health and well-being. However, very few patients receive adequate stress relief support prior to a surgical procedure.
- Conditions
- Psychological Stress, Cardiopulmonary Bypass Surgery, Coronary Artery Bypass Surgery, Cardiac Valve Replacement
- Trial name
- CARINAE (NCT05184725)
- Testing
- SaMD CARINAE
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Adhera Health, Inc.
Prevention of Venous Thromboembolism
Efficacy And Safety Of Unfractionated Heparin In Patients With Cardiovascular Surgery Using Cardiopulmonary Bypass
The primary objective of this study is to verify, through a randomized, blinded, parallel clinical trial, the efficacy of bovine heparin from Bergamo Laboratory ACTIPARIN ® product when compared to porcine heparin APP…
- Trial name
- NCT01072747
- Testing
- bovine heparin, Porcine heparin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Azidus Brasil
Bypass Complications
Best Cardiac Output During Cardiopulmonary Bypass
The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks…
- Trial name
- NCT01379638
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University Hospital
Coronary Artery Disease
Vascular Function on the First Day After Cardiac Surgery
This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique.
- Trial name
- NCT02001090
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Vascular Occlusion Test
Near-Infrared Spectroscopic (NIRS) Tissue Oxygen Saturation and the Vascular Occlusion Test in Cardiac Surgery Patients
Tissue oxygen saturation (StO2) and its recovery during a vascular occlusion test (VOT) will be measured in elective cardiac surgery patients undergoing cardiopulmonary bypass using a non-invasive near infrared spectrometry…
- Trial name
- NCT01712750
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- London Health Sciences Centre
Cardiac Perfusion
Del Nido Cardioplegia Randomized Trial
The use of a modified depolarizing cardioplegia solution in adult cardiac surgery would allow for prolonged re-dosing intervals while providing equivalent myocardial protection.
- Trial name
- NCT02442050
- Testing
- del Nido solution, Blood-based cardioplegia
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Inova Health Care Services
Congenital Heart Disease, Disorder of Fetus or Newborn
Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition…
- Trial name
- NCT01579513
- Testing
- Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Medical University of South Carolina
Cardiopulmonary Bypass Surgery
Post-market Clinical Follow-up Study on the Performance and Safety of a Vent Catheter Used During Cardiopulmonary Bypass.
Prior to the implementation of the Medical Device Regulation (MDR), the clinical evaluation of existing devices was conducted by Notified Bodies (NBs) based on clinical data obtained from equivalent devices, and CE certificates…
- Trial name
- NCT07628920
- Testing
- Vent Catheter
- Volunteers
- 45 people
- Sponsor
- Bıçakcılar Tıbbi Cihazlar Sanayi ve Ticaret A.Ş.
Bloodloss, Surgical Procedures, Operative
Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery
A Phase 2 Randomized Double-Blind Active-Controlled Study in Subjects Exposed to Cardio-pulmonary Bypass During Cardiac Surgery at High Risk of Bleeding
- Trial name
- CONSERV-2 (NCT00888940)
- Testing
- Ecallantide, Cyklokapron(R)
- Where
- 34 sites in United States, Germany and 1 more
- Volunteers
- 243 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Congenital Heart Disease in Children, Neuroprotection
Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass
Neurodevelopmental impairment due to delayed brain development and brain injury is a fundamental problem in children with critical congenital heart disease (CCHD).
- Trial name
- CRUCIAL (NCT04217421)
- Testing
- Allopurinol, Mannitol
- Where
- 4 sites in Netherlands
- Volunteers
- 236 people
- Sponsor
- dr. M.J.N.L. Benders
Aortic Aneurysm, Aortic Dissection
Freestyle Prosthesis for Aortic Root-replacement With and Without Hemiarch Replacement
The Freestyle® prosthesis (Medtronic plc, Dublin, Ireland) is a biological, porcine aortic root implanted in various combinations and techniques since the 1990s.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Endocarditis, Root Abscess
- Trial name
- NCT04068337
- Testing
- Aortic root replacement with Freestyle biological prosthesis with and without hemiarch replacement
- Where
- Switzerland
- Volunteers
- 278 people
- Sponsor
- Triemli Hospital
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Genotypes and Phenotypes in Pediatric SIRS and Sepsis
The aim of this investigation is to longitudinally quantify host gene expression and serum proteins in children with infectious and non-infectious SIRS.
- Trial name
- GAPPSS (NCT02728401)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Seattle Children's Hospital